INT82483

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 99.32 Very High Very High Very High
Deafferentation 2 98.12 Very High Very High Very High
Dopamine 10 93.52 High High
Glutamate receptor 1 90.08 High High
monoamine 2 83.72 Quite High
Neuropeptide 3 83.20 Quite High
Enkephalin 8 75.00 Quite High
Serotonin 3 75.00 Quite High
agonist 1 73.60 Quite High
Eae 1 46.00 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior administration of the 5-HT2A/2C receptor antagonist, ritanserin (1 mg/kg) or the 5-HT2A receptor antagonist, ketanserin (1 mg/kg) completely blocked the DOI-induced increases in striatal PPT mRNA in both lesioned and intact animals.
Negative_regulation (blocked) of Positive_regulation (increases) of PPT mRNA associated with antagonist
1) Confidence 0.47 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.68
The increase in the level of PPT mRNA was blocked in rats previously subjected to nigrostriatal deafferentation (i.e., 6-hydroxydopamine lesion) or pretreated with D1-receptor antagonist SCH-23390 (0.1 mg/kg), the D2-receptor antagonist eticlopride (0.5 mg/kg), or the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist MK-801 (0.1 mg/kg).
Negative_regulation (blocked) of Positive_regulation (increase) of PPT mRNA associated with glutamate receptor, antagonist and deafferentation
2) Confidence 0.45 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.31
We examined whether this was reflected in the expression of peptide mRNA in the direct and indirect striatal output pathways.6-OHDA lesioning of the nigrostriatal pathway increased striatal expression of PPE-A mRNA and decreased levels of PPT mRNA with PPE-B mRNA expression remaining unchanged.
Negative_regulation (decreased) of Positive_regulation (levels) of PPT mRNA
3) Confidence 0.05 Published 2008 Journal J Neural Transm Section Abstract Doc Link 18250952 Disease Relevance 0 Pain Relevance 0.08

General Comments

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