INT8249

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Context Info
Confidence 0.66
First Reported 1982
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 4.05
Pain Relevance 9.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cubn) Golgi apparatus (Cubn) endoplasmic reticulum (Cubn)
protein complex (Cubn) cytoplasm (Cubn)
Anatomy Link Frequency
blood 2
heart 2
neurons 1
brain 1
striatum 1
Cubn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 282 100.00 Very High Very High Very High
agonist 70 99.98 Very High Very High Very High
monoamine 16 99.58 Very High Very High Very High
opiate 12 99.16 Very High Very High Very High
midbrain 6 99.06 Very High Very High Very High
cocaine 26 98.98 Very High Very High Very High
Opioid 2 98.60 Very High Very High Very High
mu opioid receptor 12 98.20 Very High Very High Very High
fluoxetine 8 97.80 Very High Very High Very High
noradrenaline 4 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypotension 26 99.60 Very High Very High Very High
Catalepsy 7 99.34 Very High Very High Very High
Hypersensitivity 5 95.64 Very High Very High Very High
Increased Venous Pressure Under Development 33 95.00 High High
Syndrome 3 91.28 High High
Attention Deficit Hyperactivity Disorder 9 83.68 Quite High
Nash(non-alcoholic Steatohepatitis) 6 78.80 Quite High
Diuresis 4 75.60 Quite High
Heart Rate Under Development 1 74.88 Quite High
Natriuresis 4 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the hypothesis that opiates act as dopamine (DA) receptor-blocking agents thereby inducing a compensatory increase in DA receptor density during chronic administration, and that increased receptor density could account for the behavioral hypersensitivity to DA agonists seen after treatment with opiates.
Positive_regulation (increase) of DA receptor associated with dopamine, hypersensitivity, agonist and opiate
1) Confidence 0.66 Published 1982 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6173883 Disease Relevance 0.10 Pain Relevance 0.76
However, in those animals showing enhanced stereotypy or locomotion, DA receptor density was not elevated in striatum or mesolimbic areas respectively.
Neg (not) Positive_regulation (elevated) of DA receptor in striatum associated with dopamine
2) Confidence 0.66 Published 1982 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6173883 Disease Relevance 0.07 Pain Relevance 1.14
This dose of domperidone antagonized the hypotension produced by quinpirole by 85% without affecting the hypotensive action of the DA1-receptor agonist, fenoldopam. 4 These results show that at lower doses of SK&F 85174, the hypotension is due primarily to DA1-receptor activation, whereas DA2-receptor activation may also contribute to the blood pressure decrease produced by higher doses of SK&F 85174.
Positive_regulation (activation) of DA1-receptor in blood associated with hypotension and agonist
3) Confidence 0.61 Published 1987 Journal J Auton Pharmacol Section Abstract Doc Link 2888767 Disease Relevance 0.76 Pain Relevance 0.24
However, the hypotensive response seen with DA-2 receptor activation does not appear to involve cyclic-AMP.
Positive_regulation (activation) of DA-2 receptor associated with hypotension
4) Confidence 0.50 Published 1988 Journal J Auton Pharmacol Section Abstract Doc Link 2455721 Disease Relevance 0.86 Pain Relevance 0.08
This dose of domperidone antagonized the hypotension produced by quinpirole by 85% without affecting the hypotensive action of the DA1-receptor agonist, fenoldopam. 4 These results show that at lower doses of SK&F 85174, the hypotension is due primarily to DA1-receptor activation, whereas DA2-receptor activation may also contribute to the blood pressure decrease produced by higher doses of SK&F 85174.
Positive_regulation (activation) of DA2-receptor in blood associated with hypotension and agonist
5) Confidence 0.44 Published 1987 Journal J Auton Pharmacol Section Abstract Doc Link 2888767 Disease Relevance 0.75 Pain Relevance 0.23
For example, fluoxetine may not inhibit DA reuptake (to the same extent as cocaine), but may have other dopaminergic actions such as increasing DA receptor density.
Positive_regulation (increasing) of DA receptor associated with cocaine and fluoxetine
6) Confidence 0.33 Published 1997 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 9075265 Disease Relevance 0 Pain Relevance 0.97
Previous studies have indicated that the endogenous peptide, melanotropin release inhibiting factor (MIF) and its analog cyclo(Leu-Gly) ( CLG ) facilitate dopamine (DA) receptor agonist binding and inhibit DA receptor supersensitivity induced by neuroleptics and opiates.
Positive_regulation (induced) of DA receptor associated with dopamine, agonist and opiate
7) Confidence 0.16 Published 1984 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6146157 Disease Relevance 0.09 Pain Relevance 0.34
The above data suggests D1/D2 interdependence in catalepsy and a modulatory role of D1 and D2 DA receptor stimulation on the anticataleptic effect of MK-801.
Positive_regulation (stimulation) of D2 DA receptor associated with dopamine and catalepsy
8) Confidence 0.14 Published 1992 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1365866 Disease Relevance 0.40 Pain Relevance 0.24
The results suggest that activation of more than one type of DA receptor is required for the increased expression of MOR mRNA.
Positive_regulation (activation) of DA receptor associated with dopamine and mu opioid receptor
9) Confidence 0.12 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947931 Disease Relevance 0 Pain Relevance 1.13
Our findings suggest that a novel postsynaptic mechanism, i.e., an increased DA-D1 receptor function, may play a role in the sensitization.
Positive_regulation (increased) of DA-D1 receptor associated with dopamine
10) Confidence 0.11 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7616430 Disease Relevance 0.08 Pain Relevance 0.82
These interneurons receive synaptic contacts from midbrain dopamine (DA) neurons and may be regulated by DA receptor activation.
Positive_regulation (activation) of DA receptor in neurons associated with dopamine and midbrain
11) Confidence 0.11 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16012530 Disease Relevance 0 Pain Relevance 0.49
These data argue in favour of the existence of compensatory mechanisms different from the up-regulation of DA receptor densities, thereby allowing the maintenance of striatal dopaminergic transmission.
Positive_regulation (up-regulation) of DA receptor
12) Confidence 0.10 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8996800 Disease Relevance 0 Pain Relevance 0.07
Functionally, activation of the vascular DA receptor (D1 receptor) causes smooth muscle relaxation, whereas activation of the neuronal DA receptor (D2 receptor) reduces the response of the heart to nerve stimulation by depressing noradrenaline release [22, 27, 45, 48].
Positive_regulation (activation) of DA receptor in heart associated with dopamine and noradrenaline
13) Confidence 0.06 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.36 Pain Relevance 0.78
Functionally, activation of the vascular DA receptor (D1 receptor) causes smooth muscle relaxation, whereas activation of the neuronal DA receptor (D2 receptor) reduces the response of the heart to nerve stimulation by depressing noradrenaline release [22, 27, 45, 48].
Positive_regulation (activation) of DA receptor in heart associated with dopamine and noradrenaline
14) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.33 Pain Relevance 0.77
The complex motor effects of MDMA are dependent upon monoamine release followed by activation of multiple 5-HT and DA receptor subtypes in the brain [reviewed by Bankson and Cunningham (2001); Geyer (1996)].
Positive_regulation (activation) of DA receptor in brain associated with monoamine
15) Confidence 0.04 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1705495 Disease Relevance 0.24 Pain Relevance 0.30
More likely, DA and the selective agonists activated different DA receptor confirmations with differing potencies, as has been described for both D1 and D2 receptors [58-61].
Positive_regulation (activated) of DA receptor associated with dopamine and agonist
16) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.99

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