INT82495

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Context Info
Confidence 0.31
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC6) ATPase activity (ABCC6) plasma membrane (ABCC6)
transmembrane transport (ABCC6)
ABCC6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 1 96.26 Very High Very High Very High
Inflammation 1 85.64 High High
antagonist 3 75.00 Quite High
algogenic 1 60.56 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 127 100.00 Very High Very High Very High
INFLAMMATION 1 85.64 High High
Erectile Dysfunction 4 75.00 Quite High
Cv Unclassified Under Development 1 69.84 Quite High
Pain 1 60.56 Quite High
Disease 12 34.80 Quite Low
Coronary Artery Disease 2 34.56 Quite Low
Myocardial Infarction 1 31.20 Quite Low
Disorder Of Lipid Metabolism 15 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, some of the genes causally linked to FCHL (ABCC6, AKT2, FADS3, GCLM, HSD11B1) have already been associated with FCHL related traits in humans (Table 3 and Table S8).
ABCC6 Binding (linked) of associated with familial combined hyperlipidemia
1) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.79 Pain Relevance 0.04
Moxisylyte and NMI-221 showed moderate potency in antagonizing phenylephrine contraction, with comparable pA2 values for both molecules (6.5 versus 6.6, respectively). alpha-Adrenergic receptor-binding studies showed similar binding affinities for the alpha-ARA and their corresponding nitrosylated compounds.
alpha-ARA Binding (affinities) of associated with potency
2) Confidence 0.06 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10381767 Disease Relevance 0.26 Pain Relevance 0.21

General Comments

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