INT825

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 54
Total Number 54
Disease Relevance 20.25
Pain Relevance 22.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
plasma 2
muscle 2
posterior 2
smooth muscle 1
platelet 1
ADRA1D (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 100 100.00 Very High Very High Very High
Serotonin 5 100.00 Very High Very High Very High
Pain 135 99.56 Very High Very High Very High
agonist 27 99.44 Very High Very High Very High
qutenza 16 99.40 Very High Very High Very High
Dorsal horn 3 99.40 Very High Very High Very High
noradrenaline 8 99.26 Very High Very High Very High
isoflurane 13 99.22 Very High Very High Very High
Clonidine 17 99.16 Very High Very High Very High
tricyclic antidepressant 3 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 17 99.84 Very High Very High Very High
Myalgia 22 99.54 Very High Very High Very High
Benign Prostatic Hypertrophy 111 99.12 Very High Very High Very High
Apoptosis 36 99.04 Very High Very High Very High
Syncope 5 98.68 Very High Very High Very High
Herpes Simplex Virus Infection 5 98.64 Very High Very High Very High
Ganglion Cysts 1 98.64 Very High Very High Very High
Dizziness 11 98.44 Very High Very High Very High
Pain 53 98.36 Very High Very High Very High
Heart Rate Under Development 35 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experience over the last 10 years has demonstrated efficacy with the use of alpha adrenoceptor blockade in the management of BPH.
Negative_regulation (blockade) of alpha adrenoceptor associated with benign prostatic hypertrophy
1) Confidence 0.58 Published 2001 Journal Int Urol Nephrol Section Abstract Doc Link 11583366 Disease Relevance 0.23 Pain Relevance 0.08
Only the painful capsaicin injection evoked significant decreases of theta, alpha-1 and alpha-2 powers over the centro-parieto-occipital regions compared with baseline B.
Negative_regulation (decreases) of alpha-1 in occipital regions associated with pain and qutenza
2) Confidence 0.57 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11356305 Disease Relevance 0.25 Pain Relevance 1.24
Lightheadedness and syncope were accounted for by autonomic nervous failure combined with an impairment of alpha 1-adrenoceptor in vasoconstriction and the carotid sinus hypersensitivity which accompanied preceding events such as abdominal pain, defecation and micturition, which could enhance the vagally-mediated baroreceptor reflex.
Negative_regulation (impairment) of alpha 1 in sinus associated with abdominal pain, hypersensitivity, dizziness, overactive bladder, increased venous pressure under development and syncope
3) Confidence 0.57 Published 1996 Journal Jpn. Circ. J. Section Abstract Doc Link 8844304 Disease Relevance 1.35 Pain Relevance 0.10
Prazosin is a new antihypertensive agent the mechanism of action of which involves a selective blockade of postsynaptic alpha 1-adrenoceptors.
Negative_regulation (blockade) of alpha 1
4) Confidence 0.57 Published 1980 Journal Hypertension Section Abstract Doc Link 6105128 Disease Relevance 0.13 Pain Relevance 0.39
Compared to the pre-CPB period as well as to patients not exposed to CPB, CABG patients after CPB exhibited an increased elimination half-time (t1/2 beta = 180 +/- 55 min SD), central distribution volume (Vc = 0.25 +/- 0.07 L/kg), and total volume of distribution (Vdss 0.63 +/- 0.08 L/kg; Vd area 0.92 +/- 0.23 L/kg) which reflected a 33%-50% decrease in alpha 1-acid glycoprotein, the principal plasma protein to which alfentanil is bound.
Negative_regulation (decrease) of alpha 1 in plasma associated with rapifen
5) Confidence 0.57 Published 1994 Journal Anesth. Analg. Section Abstract Doc Link 8311274 Disease Relevance 0 Pain Relevance 0.48
Throughout five injections, the reduction of alpha-1 activity was contrary to the changes of pain intensity.
Negative_regulation (reduction) of alpha-1 associated with pain
6) Confidence 0.56 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12576151 Disease Relevance 1.29 Pain Relevance 1.37
Significant decreases in alpha-1 and -2 activities in posterior part of the head were found during repeated muscle pain in comparison with non-pain.
Negative_regulation (decreases) of alpha-1 in muscle associated with pain and myalgia
7) Confidence 0.56 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 12576151 Disease Relevance 1.30 Pain Relevance 1.30
Conversely, adrenergic blockade of alpha-1 and alpha-2 receptors has been shown to facilitate penile erection in both animal and human models.
Negative_regulation (blockade) of alpha-1 associated with erectile dysfunction
8) Confidence 0.49 Published 2001 Journal World J Urol Section Abstract Doc Link 11289571 Disease Relevance 0.35 Pain Relevance 0.08
The other developed more slowly and was sensitive to alpha-adrenoceptor blockade and to chemical sympathectomy with 6-hydroxydopamine.
Negative_regulation (blockade) of alpha-adrenoceptor
9) Confidence 0.43 Published 1985 Journal J. Urol. Section Abstract Doc Link 3968758 Disease Relevance 0 Pain Relevance 0.12
The effect of diclofenac-Na, glycosaminoglycanpolysulfate (GAGPS), eglin C and alpha 1-proteinase inhibitor on the activity of elastase from polymorphonuclear granulocytes (PMN-elastase) was tested under various conditions.
Negative_regulation (inhibitor) of alpha 1 in granulocytes associated with diclofenac
10) Confidence 0.42 Published 1990 Journal Arzneimittelforschung Section Abstract Doc Link 2334461 Disease Relevance 0 Pain Relevance 0.05
However, only phenylbutazone caused inactivation of alpha 1-antiproteinase in the presence of cytochrome c and H2O2.
Negative_regulation (inactivation) of alpha 1
11) Confidence 0.42 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 7811298 Disease Relevance 0.07 Pain Relevance 0.07
Labetalol is a competitive antagonist of alpha 1-, beta 1-, and beta 2-adrenergic receptors.
Negative_regulation (antagonist) of alpha 1 associated with antagonist
12) Confidence 0.42 Published 1983 Journal Drug Intell Clin Pharm Section Abstract Doc Link 6354658 Disease Relevance 0.30 Pain Relevance 0.09
The normal group, the adenomyosis group and the myoma group contained mainly type I collagen [alpha 1 (I)2 alpha 2] and a little type III collagen [alpha 1 (III)3], but alpha 1(III)/alpha 1(I) ratio decreased in order of the normal group (20.6 +/- 0.3%), the adenomyosis group (16.4 +/- 0.2%) and the myoma group (12.9 +/- 0.4%); the cellular leiomyoma type (15.8 +/- 0.2%), the fibromyoma type (12.4 +/- 0.2%) and the hyaline degeneration type (10.5 +/- 0.6%) (P less than 0.001).
Negative_regulation (decreased) of alpha 1 associated with uterine fibroids, hyalinosis, dismenorea and myoma
13) Confidence 0.42 Published 1985 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 4054826 Disease Relevance 1.64 Pain Relevance 0.39
Alpha 1-proteinase inhibitor in pure human pancreatic juice.
Negative_regulation (inhibitor) of Alpha 1
14) Confidence 0.42 Published 1983 Journal Hoppe-Seyler's Z. Physiol. Chem. Section Title Doc Link 6607205 Disease Relevance 0.19 Pain Relevance 0.16
Glycine receptor alpha1-subunit mRNA was decreased in the lumbar dorsal horn at the herpetic, but not postherpetic stage, without alteration in alpha3-subunit mRNA.
Negative_regulation (decreased) of alpha1 in dorsal horn associated with dorsal horn and herpes simplex virus infection
15) Confidence 0.42 Published 2010 Journal J. Pharmacol. Sci. Section Abstract Doc Link 20173309 Disease Relevance 1.25 Pain Relevance 1.26
Binding studies were also performed using both purified human serum albumin and human alpha 1-acid glycoprotein (AAG).
Negative_regulation (using) of alpha 1
16) Confidence 0.41 Published 1993 Journal Ther Drug Monit Section Abstract Doc Link 8249052 Disease Relevance 0 Pain Relevance 0.97
Carvedilol competitively blocks beta 1, beta 2 and alpha 1 receptors.
Negative_regulation (blocks) of alpha 1
17) Confidence 0.41 Published 1997 Journal Drugs Section Abstract Doc Link 9211087 Disease Relevance 0.23 Pain Relevance 0.03
These changes may be explained by a decrease in albumin and alpha1-acid glycoprotein.
Negative_regulation (decrease) of alpha1
18) Confidence 0.41 Published 1997 Journal Anesthesiology Section Body Doc Link 9357891 Disease Relevance 0.06 Pain Relevance 0
Alpha 1-antitrypsin (alpha1 AT) deficiency is a common hereditary disorder of Caucasians.
Negative_regulation (deficiency) of alpha1
19) Confidence 0.41 Published 1999 Journal Eur J Dermatol Section Abstract Doc Link 10523739 Disease Relevance 0.60 Pain Relevance 0.17
Reboxetine does not block serotonin reuptake or alpha1 receptors and, thus, does not appear to produce significant nausea, diarrhea, or hypotension.
Negative_regulation (block) of alpha1 associated with pressure volume 2 under development, diarrhoea, vomiting and serotonin
20) Confidence 0.41 Published 2000 Journal J Clin Psychiatry Section Abstract Doc Link 10910015 Disease Relevance 0.70 Pain Relevance 0.50

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