INT82540

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.77
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TFRC) peptidase activity (TFRC) mitochondrion (TFRC)
aging (TFRC) extracellular region (TFRC) cytoplasmic membrane-bounded vesicle (TFRC)
Anatomy Link Frequency
T cell 1
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 3 99.70 Very High Very High Very High
Spinal cord 4 92.56 High High
COX-2 inhibitor 1 88.08 High High
opioid receptor 3 85.76 High High
agonist 2 84.48 Quite High
cINOD 2 79.76 Quite High
Inflammation 10 76.08 Quite High
qutenza 33 75.40 Quite High
Pain 38 69.60 Quite High
c fibre 29 65.68 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 6 98.16 Very High Very High Very High
Nociception 6 94.56 High High
Urological Neuroanatomy 2 81.52 Quite High
INFLAMMATION 9 79.52 Quite High
Pain 34 34.56 Quite Low
Increased Venous Pressure Under Development 2 22.56 Low Low
Fever 1 10.40 Low Low
Neuropathic Pain 4 9.36 Low Low
Hyperalgesia 3 8.60 Low Low
Neurogenic Inflammation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of CD71 in T cell
1) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
In contrast to the evoked TFR, the total TFR showed a prominent decrease of power between 10 and 40 Hz, referred to as total response II (TR II).
Negative_regulation (decrease) of TFR
2) Confidence 0.27 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004625 Disease Relevance 0 Pain Relevance 0.20
Buprenorphine significantly reduced both serum amylase and FLI and T9/T10.
Negative_regulation (reduced) of T9 associated with buprenorphine
3) Confidence 0.03 Published 2004 Journal J. Surg. Res. Section Abstract Doc Link 15047123 Disease Relevance 0.63 Pain Relevance 0.65

General Comments

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