INT82541

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Context Info
Confidence 0.27
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
T cells 2
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 99.20 Very High Very High Very High
COX-2 inhibitor 1 87.36 High High
cINOD 2 79.76 Quite High
Inflammation 13 66.24 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Multiple sclerosis 23 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 15 79.52 Quite High
Multiple Sclerosis 28 5.00 Very Low Very Low Very Low
Hypercalcemia 10 5.00 Very Low Very Low Very Low
Recurrence 7 5.00 Very Low Very Low Very Low
Kidney Stones 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Flatulence 1 5.00 Very Low Very Low Very Low
Fatigue 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treg were defined as CD25+FoxP3+ CD4+ T cells [20] and as CD25+CD127?
Negative_regulation (defined) of CD25 in T cells
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0 Pain Relevance 0.05
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of CD25 in T cell
2) Confidence 0.26 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22

General Comments

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