INT82543

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.27
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TFRC) peptidase activity (TFRC) mitochondrion (TFRC)
aging (TFRC) extracellular region (TFRC) cytoplasmic membrane-bounded vesicle (TFRC)
Anatomy Link Frequency
T cell 10
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 10 98.18 Very High Very High Very High
Morphine 12 97.96 Very High Very High Very High
COX-2 inhibitor 3 97.20 Very High Very High Very High
cINOD 6 79.76 Quite High
Inflammation 3 76.08 Quite High
COX2 3 25.00 Low Low
cytokine 3 25.00 Low Low
cOX1 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 98.18 Very High Very High Very High
INFLAMMATION 9 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of Gene_expression (expression) of CD71 in T cell
1) Confidence 0.57 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of Gene_expression (expression) of CD71 in T cell
2) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.16 Pain Relevance 0.24
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of Gene_expression (expression) of CD71 in T cell
3) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
Furthermore, morphine did not alter the expression of CD3, CD4, CD8, and NKR-P1 surface markers, but significantly (p < 0.001) downregulated the expression of CD25 and CD71 receptors following in vitro activation.
Negative_regulation (downregulated) of Gene_expression (expression) of CD71 in CD3 associated with morphine
4) Confidence 0.04 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.38 Pain Relevance 0.70
These results suggested that injection of morphine in the PAG suppresses NK and T cell functions by reducing the ability of T cells to produce IL-2 and downregulating the expression of CD25 and CD71 surface activation markers.
Negative_regulation (downregulating) of Gene_expression (expression) of CD71 in T cell associated with central grey and morphine
5) Confidence 0.03 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.44 Pain Relevance 0.65

General Comments

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