INT82544

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Title
Documents 4
Total Number 5
Disease Relevance 1.41
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
T cell 2
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 100.00 Very High Very High Very High
cOX1 1 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
cINOD 23 92.32 High High
Inflammation 57 91.44 High High
Pain 6 82.80 Quite High
COX-2 inhibitor 53 61.56 Quite High
Spinal cord 2 48.16 Quite Low
Paracetamol 3 32.80 Quite Low
aspirin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 126 98.64 Very High Very High Very High
INFLAMMATION 61 91.60 High High
Pain 6 82.80 Quite High
Fever 41 82.52 Quite High
Increased Venous Pressure Under Development 1 75.40 Quite High
Death 28 50.00 Quite Low
Cancer 148 40.24 Quite Low
Familial Adenomatous Polyposis 8 25.76 Quite Low
Apoptosis 152 5.00 Very Low Very Low Very Low
Prostate Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PTGS1 is constitutively expressed and its implication in CRC risk has not been investigated very much, since its carcinogenetic role through induction of PTGS2 has been suggested only recently [16,34].
Spec (investigated) Regulation (role) of Positive_regulation (induction) of PTGS2 associated with colon cancer
1) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.77 Pain Relevance 0.08
Alternative polyadenylation of cyclooxygenase-2

A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels.

Regulation (regulated) of Positive_regulation (polyadenylation) of cyclooxygenase-2
2) Confidence 0.16 Published 2005 Journal Nucleic Acids Research Section Title Doc Link PMC1088970 Disease Relevance 0 Pain Relevance 0
Alternative polyadenylation of cyclooxygenase-2

A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels.

Regulation (regulated) of Positive_regulation (polyadenylation) of cyclooxygenase-2
3) Confidence 0.16 Published 2005 Journal Nucleic Acids Research Section Title Doc Link PMC1088970 Disease Relevance 0 Pain Relevance 0
Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors.
Regulation (regulation) of in T cell Positive_regulation (Induction) of cyclooxygenase-2 in T lymphocytes associated with cox1
4) Confidence 0.10 Published 1999 Journal J. Immunol. Section Title Doc Link 10384106 Disease Relevance 0.14 Pain Relevance 0.30
Cyclooxygenase-2 (COX-2) is the inducible isoform, which is regulated by growth factors and different cytokines such as IL1?
Regulation (regulated) of Positive_regulation (inducible) of Cyclooxygenase-2 associated with cytokine
5) Confidence 0.08 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.50 Pain Relevance 0.33

General Comments

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