INT82546

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.69
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cell 4
CD86 2
lymphocyte 2
CD69 (Homo sapiens)
Pain Link Frequency Relevance Heat
cOX-2 inhibitor 1 97.84 Very High Very High Very High
inflammatory 87 94.64 High High
cytokine 51 88.84 High High
cINOD 4 79.76 Quite High
spastic colon 18 76.84 Quite High
pain 4 76.16 Quite High
depression 7 49.80 Quite Low
COX2 2 25.00 Low Low
cOX1 1 25.00 Low Low
inflammatory response 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 150 96.40 Very High Very High Very High
INFLAMMATION 101 94.64 High High
Communicable Diseases 19 92.72 High High
Infection 47 92.48 High High
Bacterial Infection 2 82.44 Quite High
Worm Infection 13 80.68 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

15 76.84 Quite High
Pain 3 76.16 Quite High
Fatigue 16 75.12 Quite High
Disease 21 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of Gene_expression (expression) of CD69 in T cell
1) Confidence 0.47 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.16 Pain Relevance 0.24
Similarly, increased expression of MHC II, CD86, and CD69 molecules, but decreased CD62L levels, have also been observed in activated eosinophils after in vitro exposure to Strongyloides stercolaris antigens in a murine model [47].
Negative_regulation (decreased) of Gene_expression (expression) of CD69 in CD86
2) Confidence 0.20 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.44 Pain Relevance 0
As a consequence, some cellular immune functions may be suppressed, for example, lowered NK cell activity and ex vivo expression of T cell activation markers, such as CD69.
Negative_regulation (lowered) of Gene_expression (expression) of CD69 in T cell
3) Confidence 0.10 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2964729 Disease Relevance 1.21 Pain Relevance 0.44
MAIN RESULTS: Absolute number of CD3+, CD4+, and CD8+, and expression of HLA-DR and activation marker CD25+, CD26+, and CD69+ decreased more in response to surgery after BAL.
Negative_regulation (decreased) of Gene_expression (expression) of CD69
4) Confidence 0.07 Published 2005 Journal J Clin Anesth Section Body Doc Link 16297751 Disease Relevance 0.06 Pain Relevance 0
However, the decrease of lymphocyte number was less marked than the large decrease of transcript levels of CD28, CD69 and LCK.
Negative_regulation (decrease) of Gene_expression (levels) of CD69 in lymphocyte
5) Confidence 0.07 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.74 Pain Relevance 0

General Comments

This test has worked.

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