INT82547

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Context Info
Confidence 0.29
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.04
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
T cell 6
regulatory T cells 4
endometrium 2
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 3 97.20 Very High Very High Very High
endometriosis 52 94.12 High High
Inflammation 45 81.76 Quite High
cINOD 6 79.76 Quite High
cytokine 34 71.04 Quite High
chemokine 10 69.12 Quite High
rheumatoid arthritis 19 68.96 Quite High
cOX1 3 25.00 Low Low
COX2 3 25.00 Low Low
tolerance 20 12.52 Low Low
Disease Link Frequency Relevance Heat
Endometriosis 90 94.12 High High
Cicatrix 47 91.20 High High
Lymphatic System Cancer 39 85.16 High High
Malignant Neoplastic Disease 7 82.24 Quite High
INFLAMMATION 51 81.76 Quite High
Congenital Anomalies 5 74.72 Quite High
Disease 52 73.88 Quite High
Htlv Types I And Ii 3 73.12 Quite High
Autoimmune Disease 32 71.20 Quite High
Leukemia 4 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease of CD25 antigen expression with a concomitant increase of CD69 expression has been observed in the endometrium according to the menstrual cycle changes [21].
Negative_regulation (decrease) of Gene_expression (expression) of CD25 in endometrium
1) Confidence 0.29 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.22 Pain Relevance 0.27
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of Gene_expression (expression) of CD25 in T cell
2) Confidence 0.26 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of Gene_expression (expression) of CD25 in T cell
3) Confidence 0.26 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.15 Pain Relevance 0.22
Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene.
Negative_regulation (diminished) of Gene_expression (expression) of CD25 in T cell
4) Confidence 0.26 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.16 Pain Relevance 0.24
They also suppressed the growth of CD4+ CD25?
Negative_regulation (suppressed) of Gene_expression (growth) of CD25
5) Confidence 0.26 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.03 Pain Relevance 0.06
At least a small number of non-regulatory activated effector T cells usually contaminate isolated CD4+CD25high regulatory T cells, due to the overlapping expression of CD25.
Negative_regulation (isolated) of Gene_expression (expression) of CD25 in regulatory T cells
6) Confidence 0.15 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.27 Pain Relevance 0.13
Development of CD4+CD25high regulatory T cells
Negative_regulation (Development) of Gene_expression (regulatory T cells) of CD25high in regulatory T cells
7) Confidence 0.13 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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