INT82552

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
monocytes 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 99.96 Very High Very High Very High
anesthesia 1 99.04 Very High Very High Very High
Inflammation 4 94.80 High High
spinal inflammation 1 55.68 Quite High
Disease Link Frequency Relevance Heat
Overdose 1 99.04 Very High Very High Very High
Diabetes Mellitus 6 95.68 Very High Very High Very High
Uveitis 9 87.16 High High
Stress 3 86.64 High High
Hyperglycemia 1 78.60 Quite High
INFLAMMATION 2 71.64 Quite High
Low Back Pain 1 55.68 Quite High
Disease 1 54.60 Quite High
Vasculitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semiquantitative PCR revealed that E-selectin and IL-6 gene expressions were increased in rats following LPS injection, and an overdose of tamoxifen, an estrogen receptor antagonist, reversed the effect of 17beta-estradiol on E-selectin, but not its effect on IL-6.
Negative_regulation (reversed) of Regulation (effect) of IL-6 associated with antagonist and overdose
1) Confidence 0.38 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384138 Disease Relevance 0.84 Pain Relevance 0.19
Results show that the effect of high glucose on lipid peroxidation, IL-6, IL-8, MCP-1, and TNF-alpha secretion was inhibited by curcumin in cultured monocytes.
Negative_regulation (inhibited) of Regulation (effect) of IL-6 in monocytes
2) Confidence 0.36 Published 2009 Journal Antioxid. Redox Signal. Section Abstract Doc Link 18976114 Disease Relevance 0.58 Pain Relevance 0.17

General Comments

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