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Context Info
Confidence 0.86
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.03
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 2 95.92 Very High Very High Very High
Paracetamol 8 92.84 High High
Inflammation 39 85.84 High High
anesthesia 3 53.84 Quite High
Inflammatory response 6 51.44 Quite High
ischemia 13 50.00 Quite Low
cytokine 16 43.56 Quite Low
Versed 1 41.44 Quite Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 9 91.36 High High
Stress 11 87.04 High High
Carcinosarcoma 1 86.08 High High
INFLAMMATION 46 85.84 High High
Gallstones 1 85.44 High High
Overdose 1 75.76 Quite High
Apoptosis 42 69.16 Quite High
Reperfusion Injury 8 50.00 Quite Low
Breast Cancer 1 45.52 Quite Low
Adhesions 13 44.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding suggests depletion of HO-1 might be a reasonable result for the secondary effect of SM and disturbing between the rate of ROS production and the effect of protective antioxidatiants.

Protein_catabolism (depletion) of HO
1) Confidence 0.86 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0 Pain Relevance 0
Carbon monoxide (CO), one of the products of heme oxygenase (HO) catalyzed heme degradation, is a vasodilator.
Protein_catabolism (degradation) of HO
2) Confidence 0.82 Published 2003 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 12709573 Disease Relevance 0.39 Pain Relevance 0
HO-1 degrades heme into biliverdin, free iron, and CO [12] and is one of the most prominent lines of cellular defense against damage induced by I/Ri.
Protein_catabolism (degrades) of HO-1
3) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.40 Pain Relevance 0.10
HO catalyzes the oxidative degradation of heme.
Protein_catabolism (degradation) of HO
4) Confidence 0.19 Published 2009 Journal Int. J. Neurosci. Section Abstract Doc Link 19922363 Disease Relevance 0 Pain Relevance 0.05
Under these circumstances, the release of CO and bilirubin IXalpha, terminal products of the HO-mediated heme degradation, became 2. 5-fold greater than the control.
Protein_catabolism (degradation) of HO
5) Confidence 0.08 Published 1999 Journal Hepatology Section Abstract Doc Link 10385652 Disease Relevance 0.23 Pain Relevance 0.64

General Comments

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