INT82608

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.28
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 99.98 Very High Very High Very High
Enkephalin 1 98.84 Very High Very High Very High
opioid receptor 4 89.08 High High
agonist 1 86.92 High High
Kinase C 1 86.32 High High
cytokine 1 54.64 Quite High
narcan 1 25.00 Low Low
antagonist 2 15.16 Low Low
imagery 6 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bordatella Infection 1 98.28 Very High Very High Very High
Ovarian Cancer 100 96.36 Very High Very High Very High
Cancer 75 95.24 Very High Very High Very High
Neuroblastoma 3 90.00 High High
Solid Tumor 8 81.60 Quite High
Hypoxia 4 56.48 Quite High
Apoptosis 8 53.60 Quite High
Targeted Disruption 1 38.92 Quite Low
Rhinitis 1 12.28 Low Low
Pressure And Volume Under Development 7 11.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase.
Positive_regulation (requires) of Phosphorylation (phosphorylation) of Src associated with enkephalin
1) Confidence 0.49 Published 1999 Journal J. Neurochem. Section Title Doc Link 10386963 Disease Relevance 0 Pain Relevance 0.14
The mu-opioid-induced IKK phosphorylation required extracellular signal-regulated protein kinase, phosphatidylinositol 3-kinase and c-Src.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of c-Src associated with opioid
2) Confidence 0.45 Published 2005 Journal Neurosignals Section Abstract Doc Link 16088228 Disease Relevance 0.26 Pain Relevance 0.31
EA5 led to dissociation of Src from EphA2, resulting in decreased phosphorylation of Src and thus VEGF expression [99].

2.7.

Positive_regulation (resulting) of Phosphorylation (phosphorylation) of Src
3) Confidence 0.10 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.02 Pain Relevance 0.03

General Comments

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