INT82609

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Context Info
Confidence 0.80
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.45
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
Anatomy Link Frequency
heart 1
T cell 1
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.82 Very High Very High Very High
Opioid 21 99.74 Very High Very High Very High
Kinase C 4 98.76 Very High Very High Very High
cytokine 28 98.74 Very High Very High Very High
peptic ulcer disease 1 97.56 Very High Very High Very High
addiction 2 93.36 High High
rheumatoid arthritis 77 92.08 High High
Osteoarthritis 34 91.52 High High
opioid receptor 6 88.60 High High
agonist 3 86.92 High High
Disease Link Frequency Relevance Heat
Pox Virus Infection 5 99.54 Very High Very High Very High
Apoptosis 201 99.00 Very High Very High Very High
Stomach Cancer 6 98.44 Very High Very High Very High
Bordatella Infection 2 97.80 Very High Very High Very High
Disease 71 97.56 Very High Very High Very High
Ulcers 3 97.24 Very High Very High Very High
Adhesions 32 96.60 Very High Very High Very High
Leukemia 12 95.92 Very High Very High Very High
Ovarian Cancer 101 95.44 Very High Very High Very High
Cancer 248 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ligand-exchange detection is coupled to a C8 reversed-phase column to separate several nonphosphorylated enkephalins and the phosphorylated peptides pp60 c-src (P) and M2170.
Phosphorylation (phosphorylated) of c-src associated with enkephalin
1) Confidence 0.80 Published 2003 Journal Anal. Chem. Section Abstract Doc Link 14670045 Disease Relevance 0 Pain Relevance 0.10
PLCbeta, PKC, and CaMKII were shown to be involved in Galpha14QL-mediated c-Src phosphorylation.
Phosphorylation (phosphorylation) of c-Src associated with kinase c
2) Confidence 0.80 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15155836 Disease Relevance 0.15 Pain Relevance 0.23
Upon translocation, CagA is tyrosine phosphorylated by Src family kinases (SFKs), which themselves become inactivated via a negative feedback loop.
Phosphorylation (phosphorylated) of Src
3) Confidence 0.80 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.86 Pain Relevance 0.10
Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase.
Phosphorylation (phosphorylation) of Src associated with enkephalin
4) Confidence 0.79 Published 1999 Journal J. Neurochem. Section Title Doc Link 10386963 Disease Relevance 0 Pain Relevance 0.14
Together these data suggest that RGD stimulates c-Src dependent and independent tyrosine phosphorylation of cellular proteins.
Phosphorylation (phosphorylation) of c-Src
5) Confidence 0.61 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.05
A major upstream kinase known to phosphorylate STAT3 during cytokine/growth factor stimulation is Janus kinase-2 (JAK2).6 However, c-Src can also mediate tyrosine phosphorylation of STAT3.20 Similarly, another NTK, BMX (bone marrow tyrosine kinase in chromosome X), a member of the TEC family,21, 22 has been shown to phosphorylate and activate STAT3 in multiple cell types.21, 23-25 BMX has a wide expression profile but has a particularly high expression in the heart and plays a broad role in cell signaling.21, 22 Specifically, during nitric oxide generation in the heart, BMX activation via PKC?
Phosphorylation (phosphorylation) of c-Src in heart associated with cytokine
6) Confidence 0.61 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.29 Pain Relevance 0.08
The mu-opioid-induced IKK phosphorylation required extracellular signal-regulated protein kinase, phosphatidylinositol 3-kinase and c-Src.
Phosphorylation (phosphorylation) of c-Src associated with opioid
7) Confidence 0.61 Published 2005 Journal Neurosignals Section Abstract Doc Link 16088228 Disease Relevance 0.26 Pain Relevance 0.31
This study extends these finding by demonstrating that the potent protein tyrosine phosphatase inhibitor, 3,4-Dephostatin, blocks MNTX inhibition of VEGF-induced Src and Akt phosphorylation. 3,4-Dephostatin is known to block the phosphatase activity of PTP-1B, SHPTP-1 and CD45 [20,40,46-48].
Phosphorylation (phosphorylation) of Src
8) Confidence 0.56 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.21 Pain Relevance 0
The molecular pathway analysis of the TP plant extract revealed that it inhibits the phosphorylation of beta-catenin, via Src dephosphorylation, and consequently converts its role from a transcriptional regulator to a cell-cell adhesion molecule.
Phosphorylation (dephosphorylation) of Src associated with adhesions
9) Confidence 0.53 Published 2010 Journal J Ethnopharmacol Section Abstract Doc Link 19897022 Disease Relevance 0.78 Pain Relevance 0.09
Inhibition of tyrosine phosphatase activity (3,4-dephostatin) blocked the synergy between MNTX and temsirolimus and increased VEGF-induced tyrosine phosphorylation of Src with enhanced PI3 kinase and mTOR Complex 2-dependent phosphorylation of Akt and subsequent activation of mTOR Complex 1 (rapamycin and temsirolimus target), while silencing Src, Akt or mTOR complex 2 components blocked VEGF-induced angiogenic events.


Phosphorylation (phosphorylation) of Src
10) Confidence 0.43 Published 2010 Journal J Angiogenes Res Section Abstract Doc Link PMC2831839 Disease Relevance 0.11 Pain Relevance 0.07
One possible mechanism of attenuating Src tyrosine phosphorylation is through tyrosine phosphatase activity [18,19].
Phosphorylation (phosphorylation) of Src
11) Confidence 0.43 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.09
Our previous studies indicate that MNTX attenuates VEGF-induced pp60 Src activation (tyrosine phosphorylation) [6,10].
Phosphorylation (phosphorylation) of pp60 Src
12) Confidence 0.37 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.08
Moreover, Src phosphorylates p27, a protein known to inhibit cell cycle progression especially at the G1/S transition [54].
Phosphorylation (phosphorylates) of Src
13) Confidence 0.30 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.90 Pain Relevance 0
Notably, phosphorylation of src is consistent with T cell activation [27].


Phosphorylation (phosphorylation) of src in T cell
14) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.02 Pain Relevance 0.34
Src can further phosphorylate FAK at several additional sites, including Tyr925.
Phosphorylation (phosphorylate) of Src
15) Confidence 0.13 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.13 Pain Relevance 0
EA5 led to dissociation of Src from EphA2, resulting in decreased phosphorylation of Src and thus VEGF expression [99].

2.7.

Phosphorylation (phosphorylation) of Src
16) Confidence 0.13 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.01 Pain Relevance 0.03
Knowledge that the protein A36R of the vaccinia virus, a poxvirus, is phosphorylated by both Src and Abl receptor tyrosine kinases led Reeves et al. [13] to examine the effects of inhibiting A36R phosphorylation.
Phosphorylation (phosphorylated) of Src associated with pox virus infection
17) Confidence 0.09 Published 2006 Journal Genome Biol Section Body Doc Link PMC1431708 Disease Relevance 0.73 Pain Relevance 0

General Comments

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