INT82610

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 53
Total Number 53
Disease Relevance 26.89
Pain Relevance 7.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
Anatomy Link Frequency
cardiomyocytes 3
myocardium 1
spinal 1
thyroid 1
capillary 1
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 16 99.92 Very High Very High Very High
addiction 10 99.92 Very High Very High Very High
Neuropathic pain 6 99.92 Very High Very High Very High
Glutamate receptor 1 99.84 Very High Very High Very High
opioid receptor 17 99.62 Very High Very High Very High
nMDA receptor 2 99.60 Very High Very High Very High
Inflammation 72 99.50 Very High Very High Very High
Opioid 42 99.42 Very High Very High Very High
Pain 20 99.00 Very High Very High Very High
Enkephalin 2 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 92 100.00 Very High Very High Very High
Infection 32 100.00 Very High Very High Very High
Ulcers 7 100.00 Very High Very High Very High
Pancreatic Cancer 350 99.92 Very High Very High Very High
Neuropathic Pain 6 99.92 Very High Very High Very High
Mesothelioma 47 99.84 Very High Very High Very High
Stomach Cancer 14 99.74 Very High Very High Very High
Bordatella Infection 3 99.58 Very High Very High Very High
INFLAMMATION 75 99.50 Very High Very High Very High
Malignant Neoplastic Disease 37 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.
Positive_regulation (Activation) of Src in spinal associated with nervous system injury and hypersensitivity
1) Confidence 0.67 Published 2006 Journal J. Neurosci. Section Title Doc Link 16928856 Disease Relevance 0.81 Pain Relevance 0.29
The activation of Janus-activated kinase 1 and c-Src, implicated in STAT3 activation, was also inhibited by the vanilloid, with no effect on extracellular signal-regulated kinase 1/2 activation.
Positive_regulation (activation) of c-Src
2) Confidence 0.67 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.08 Pain Relevance 0
Therefore, preventing the activation of the Src/ERK signaling cascade in microglia might provide a fruitful strategy for treating neuropathic pain.
Positive_regulation (activation) of Src in microglia associated with neuropathic pain
3) Confidence 0.67 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16928856 Disease Relevance 0.76 Pain Relevance 0.25
The middle arrow indicates a phosphorylated protein band that exhibited enhanced phosphorylation during RGD-stimulation and seems to be dependent on c-Src activation as it is greatly diminished upon inclusion of DNSrc.
Positive_regulation (activation) of c-Src in band
4) Confidence 0.67 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.05
Microglial activation might involve beta-amyloid binding and activation of cell surface immune and adhesion molecules such as CD45, CD40, CD36 and integrins, with the subsequent recruitment of Src family tyrosine kinases such as Fyn, Lyn and Syk kinases.
Positive_regulation (recruitment) of Src associated with alzheimer's dementia and adhesions
5) Confidence 0.67 Published 2005 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 15853747 Disease Relevance 1.26 Pain Relevance 0.37
Arrestins also link GPCRs to several signalling pathways, including activation of the non-receptor tyrosine kinase SRC and mitogen-activated protein kinase.
Positive_regulation (activation) of SRC
6) Confidence 0.67 Published 2001 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 11584310 Disease Relevance 0.14 Pain Relevance 0.19
Aberrant c-Src protein kinase activation has been identified as one of the molecular alterations involved in human pancreatic carcinogenesis.
Positive_regulation (activation) of c-Src
7) Confidence 0.67 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14627343 Disease Relevance 0.41 Pain Relevance 0
Owing to the inactivation of c-Src via CagA interaction, vinculin is dephosphorylated at tyrosine residues, 100 and 1065, by corresponding phosphatases.
Positive_regulation (inactivation) of c-Src
8) Confidence 0.49 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.97 Pain Relevance 0.09
Generation of c-Src Adenoviral Constructs and their Expression in Adult Cardiomyocytes
Positive_regulation (Generation) of c-Src in Cardiomyocytes
9) Confidence 0.49 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.06 Pain Relevance 0
We then sought to link c-Src and STAT3 in our 3D model through the adenoviral expression of a dominant negative form of c-Src (DNSrc).
Positive_regulation (link) of c-Src
10) Confidence 0.49 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0
Collectively, these results demonstrate functional regulation of JNK by the delta-opioid receptor, and this pathway requires Gbetagamma, Src kinases and the small GTPases Rac and Cdc42.
Positive_regulation (requires) of Src associated with opioid receptor
11) Confidence 0.49 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12558970 Disease Relevance 0.17 Pain Relevance 0.42
The mu-opioid-induced IKK phosphorylation required extracellular signal-regulated protein kinase, phosphatidylinositol 3-kinase and c-Src.
Positive_regulation (required) of c-Src associated with opioid
12) Confidence 0.49 Published 2005 Journal Neurosignals Section Abstract Doc Link 16088228 Disease Relevance 0.26 Pain Relevance 0.31
The mu-opioid-induced activation of STAT3 is sensitive to receptor was further shown to pertussis toxin treatment and required JAK and Src tyrosine kinases, but not phosphatidylinositol 3-kinase.
Neg (not) Positive_regulation (required) of Src associated with bordatella infection and opioid
13) Confidence 0.49 Published 2004 Journal Neuroreport Section Abstract Doc Link 15194868 Disease Relevance 0.26 Pain Relevance 0.35
Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase.
Positive_regulation (requires) of Src associated with enkephalin
14) Confidence 0.49 Published 1999 Journal J. Neurochem. Section Title Doc Link 10386963 Disease Relevance 0 Pain Relevance 0.14
Upon translocation, CagA is tyrosine phosphorylated by Src family kinases (SFKs), which themselves become inactivated via a negative feedback loop.
Positive_regulation (inactivated) of Src
15) Confidence 0.49 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.87 Pain Relevance 0.10
We and others have previously published that VEGF induces Src and PI3 kinase activation in human EC [6,16,17].
Positive_regulation (activation) of Src
16) Confidence 0.47 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0
RGD stimulation of adult cardiomyocytes in vitro caused both STAT3 redistribution and activation that were accompanied by the activation and redistribution of c-Src and the TEC family kinase, BMX, but not JAK2.
Positive_regulation (activation) of c-Src in cardiomyocytes
17) Confidence 0.45 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2443357 Disease Relevance 0.51 Pain Relevance 0
We have shown previously in vivo4, 5 that PO can cause integrin activation, resulting in cytoskeletal assembly and activation of c-Src and FAK, and tyrosine phosphorylation of several cytoskeleton-bound proteins in 24-48 h PO myocardium.
Positive_regulation (activation) of c-Src in myocardium
18) Confidence 0.45 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.07
Although our previous work both in 48 h PO myocardium and in RGD-stimulated adult cardiomyocytes3, 4 demonstrates c-Src recruitment and activation, expression of DNSrc in cardiomyocytes in the 3D environment did not affect the RGD-stimulated STAT3 phosphorylation.
Positive_regulation (activation) of c-Src in cardiomyocytes
19) Confidence 0.45 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.04
In this study we assessed the activation status of five oncogenic signaling pathways in 157 ovarian tumor samples based on the activation observed in a mammalian cell line following tranfection of adenovirus expressing human c-Myc, activated H-Ras, human c-Src, human E2F3, or ?
Positive_regulation (activated) of c-Src associated with ovarian cancer
20) Confidence 0.45 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.47 Pain Relevance 0

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