INT82650

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2011
Negated 14
Speculated 9
Reported most in Abstract
Documents 312
Total Number 321
Disease Relevance 211.71
Pain Relevance 55.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
endometrium 13
bladder 7
leukocytes 7
brain 7
liver 6
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 106 100.00 Very High Very High Very High
ASIC 54 100.00 Very High Very High Very High
metalloproteinase 17 100.00 Very High Very High Very High
Hippocampus 127 99.98 Very High Very High Very High
antagonist 35 99.96 Very High Very High Very High
Ultiva 54 99.80 Very High Very High Very High
Paracetamol 11 99.78 Very High Very High Very High
ischemia 1743 99.76 Very High Very High Very High
dexamethasone 550 99.76 Very High Very High Very High
tricyclic antidepressant 3 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 5543 100.00 Very High Very High Very High
Lymphatic System Cancer 1014 100.00 Very High Very High Very High
Neurodegenerative Disease 144 100.00 Very High Very High Very High
Dysmenorrhea 106 100.00 Very High Very High Very High
Leukemia 101 100.00 Very High Very High Very High
B-cell Lymphoma 11 100.00 Very High Very High Very High
B-cell Acute Lymphoblastic Leukemia 2 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 1 1 100.00 Very High Very High Very High
Hepatotoxicity 129 99.98 Very High Very High Very High
Cancer 694 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Very few matured chondrocytes expressed bcl-2.
Gene_expression (expressed) of bcl-2 in chondrocytes
1) Confidence 0.78 Published 1999 Journal Hua Xi Kou Qiang Yi Xue Za Zhi Section Body Doc Link 12539283 Disease Relevance 0 Pain Relevance 0
METHODS: Tdt-mediated dUTP nick end labeling (TUNEL) and mRNA in situ hybridization were used in observation of apoptosis and bcl-2 gene expression in TMJ of SD rats during prenatal and postnatal developmental period.
Gene_expression (expression) of bcl-2
2) Confidence 0.78 Published 1999 Journal Hua Xi Kou Qiang Yi Xue Za Zhi Section Body Doc Link 12539283 Disease Relevance 0 Pain Relevance 0
RESULTS: Apoptosis involved in different development periods of condylar cartilage, and the cells of apoptosis mainly located in the proliferative zone and the area between the prehypertrophic zone and the late hypertrophic zone., bcl-2 was expressed in chondrocytes throughout condylar cartilage with high levels in proliferative and prehypertrophic chondrocytes and obvious low levels in the late hypertrophic chondrocytes.
Gene_expression (expressed) of bcl-2 in chondrocytes
3) Confidence 0.78 Published 1999 Journal Hua Xi Kou Qiang Yi Xue Za Zhi Section Body Doc Link 12539283 Disease Relevance 0 Pain Relevance 0
Our results showed that 20 microM FL treatment can significantly increase the proliferation rate of NSCs (p<0.05), and up-regulate the mRNA and protein expressions of Bcl-2 in Day-7 FL-treated NSCs (p<0.01).
Gene_expression (expressions) of Bcl-2 in NSCs associated with fluoxetine
4) Confidence 0.78 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.40 Pain Relevance 0.95
Using microdialysis with high performance liquid chromatography- electrochemical detection, the functional release of serotonin in the differentiating NSCs with FL treatment was increased and simultaneously regulated by the Bcl-2 expressions.
Gene_expression (expressions) of Bcl-2 in NSCs associated with serotonin and fluoxetine
5) Confidence 0.78 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.19 Pain Relevance 0.79
In sum, the study results indicate that antidepressant administration can increase NSCs survival, promote the neurite development, and facilitate NSCs differentiating into the functional serotoninergic neurons via the modulation of Bcl-2 expression.
Gene_expression (expression) of Bcl-2 in NSCs associated with antidepressant
6) Confidence 0.78 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.07 Pain Relevance 0.62
Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion.
Gene_expression (expression) of Bcl-2 in motor neurons associated with sciatica
7) Confidence 0.77 Published 2001 Journal Exp. Neurol. Section Title Doc Link 11259110 Disease Relevance 0.92 Pain Relevance 0.45
Ischemia/reperfusion increases the overall expression of both bcl-2 and bax proteins, but bcl-2 is lost from the reperfused area as indicated by TUNEL staining.
Gene_expression (expression) of bcl-2 associated with ischemia
8) Confidence 0.77 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.55 Pain Relevance 0.15
Coronary reperfusion following ischemia: different expression of bcl-2 and bax proteins, and cardiomyocyte apoptosis.
Gene_expression (expression) of bcl-2 in cardiomyocyte associated with ischemia and apoptosis
9) Confidence 0.77 Published 2001 Journal Jpn Heart J Section Title Doc Link 11933925 Disease Relevance 0.60 Pain Relevance 0.13
To this end, we studied the expression of the pro- and anti-apoptotic factors, bax and bcl-2, respectively, in reperfused ischemic hearts and in hearts injected with bFGF or saline.
Gene_expression (expression) of bcl-2 in hearts associated with apoptosis
10) Confidence 0.77 Published 2001 Journal Jpn Heart J Section Abstract Doc Link 11933925 Disease Relevance 0.51 Pain Relevance 0.12
Immunohistochemical assay was used to reveal the protein expression of Bax, Bcl2, and the activation of caspase 3.
Gene_expression (expression) of Bcl2
11) Confidence 0.77 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.15 Pain Relevance 0.67
These findings suggest that morphine exposure during the first embryonic days may enhance the susceptibility of neuroblasts to apoptosis by upregulating the ratio of Bax to Bcl-2 protein expression and increasing downstream caspase-3 activity.
Gene_expression (expression) of Bcl-2 protein in neuroblasts associated with apoptosis and morphine
12) Confidence 0.77 Published 2010 Journal J. Mol. Neurosci. Section Abstract Doc Link 19936637 Disease Relevance 0.15 Pain Relevance 0.64
Bcl-2 expression was determined by monoclonal antibody staining and fluorescence-activated cell-sorting measurement.
Gene_expression (expression) of Bcl-2
13) Confidence 0.76 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 0.99 Pain Relevance 0.39
At all concentrations tested the influence of sodium salicylate and hydrocortisone on Bcl-2 expression was not significant.
Gene_expression (expression) of Bcl-2
14) Confidence 0.76 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 0.99 Pain Relevance 0.37
Indomethacin (1 mM) and ibuprofen (1 mM) significantly reduced Bcl-2 expression in the cancer cell lines tested and might be thought responsible for the observed increase in apoptosis.
Gene_expression (expression) of Bcl-2 associated with cancer and apoptosis
15) Confidence 0.76 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 1.04 Pain Relevance 0.37
In this study we wanted to determine the influence of different NSAIDs (indomethacin, ibuprofen and sodium salicylate) and hydrocortisone on Bcl-2 expression and the apoptotic behavior of head and neck tumor cell lines and normal oral keratinocytes.
Gene_expression (expression) of Bcl-2 in neck associated with cancer, cinod and apoptosis
16) Confidence 0.76 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11813903 Disease Relevance 0.99 Pain Relevance 0.34
[Expression of bcl-2 protein in adenomyosis].
Gene_expression (Expression) of bcl-2 associated with dismenorea
17) Confidence 0.76 Published 2000 Journal Zhonghua Fu Chan Ke Za Zhi Section Title Doc Link 11775943 Disease Relevance 0.29 Pain Relevance 0.20
METHODS: Endometrium specimens were obtained from 16 normal uterus and 32 with adenomyosis. bcl-2 expression in these paraffin embraced specimens was examined by immunohistochemical technique with specific monoclonal antibodies.
Gene_expression (expression) of bcl-2 in uterus
18) Confidence 0.76 Published 2000 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 11775943 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: The decrease of cellular apoptosis resulted from the high bcl-2 expression may play an important role in the pathogenesis of adenomyosis.


Gene_expression (expression) of bcl-2
19) Confidence 0.76 Published 2000 Journal Zhonghua Fu Chan Ke Za Zhi Section Body Doc Link 11775943 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: To investigate the expression of B cell lymphoma/leukemia-2 (Bcl-2) protein in adenomyosis and its clinical implication.
Spec (investigate) Gene_expression (expression) of Bcl-2 in B cell associated with leukemia, b-cell lymphoma and dismenorea
20) Confidence 0.76 Published 2000 Journal Zhonghua Fu Chan Ke Za Zhi Section Abstract Doc Link 11775943 Disease Relevance 0.37 Pain Relevance 0.17

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