INT82652

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Context Info
Confidence 0.37
First Reported 1999
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 3.50
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
neurons 1
MCA 1
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 10 99.36 Very High Very High Very High
isoflurane 5 98.92 Very High Very High Very High
Inflammation 238 98.12 Very High Very High Very High
Glutamate 23 95.88 Very High Very High Very High
cytokine 13 91.28 High High
Inflammatory response 37 87.84 High High
Inflammatory stimuli 30 84.44 Quite High
cva 1 84.40 Quite High
substance P 45 83.12 Quite High
qutenza 14 59.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 303 98.48 Very High Very High Very High
Cystitis 36 98.12 Very High Very High Very High
Hypertrophy 3 88.92 High High
Infection 7 86.84 High High
Penetrating Head Injuries 5 85.12 High High
Cv General 3 Under Development 1 84.40 Quite High
Brain Injury 10 80.80 Quite High
Injury 80 76.52 Quite High
Pressure And Volume Under Development 10 75.80 Quite High
Bladder Cancer 8 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
THRR was significantly attenuated in a dose dependent manner during isoflurane anesthesia.
Negative_regulation (attenuated) of THRR associated with anesthesia and isoflurane
1) Confidence 0.37 Published 2001 Journal Masui Section Abstract Doc Link 11797358 Disease Relevance 0 Pain Relevance 0.87
The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.
Negative_regulation (attenuated) of PAR-1
2) Confidence 0.35 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.84 Pain Relevance 0.15
It remains to be determined whether PAR1 receptor blockade or selective gene silencing of transcripts downstream of PAR activation will ameliorate the clinical manifestation of cystitis.
Spec (whether) Negative_regulation (blockade) of PAR1 associated with cystitis
3) Confidence 0.27 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.76 Pain Relevance 0.22
It remains to be determined whether or not mechanisms targeting PAR1 gene silencing or PAR1 blockade will ameliorate the clinical manifestations of cystitis.



Spec (whether) Negative_regulation (blockade) of PAR1 associated with cystitis
4) Confidence 0.27 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1853108 Disease Relevance 0.78 Pain Relevance 0.31
It remains to be determined whether PAR1 receptor blockade or selective gene silencing transcripts downstream of PAR activation will ameliorate the clinical manifestation of cystitis.
Spec (whether) Negative_regulation (blockade) of PAR1 associated with cystitis
5) Confidence 0.27 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.44 Pain Relevance 0.22
It remains to be determined whether or not mechanisms targeting PAR1 gene silencing or PAR1 blockade will ameliorate the clinical manifestation of cystitis.



Spec (whether) Negative_regulation (blockade) of PAR1 associated with cystitis
6) Confidence 0.27 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1853107 Disease Relevance 0.69 Pain Relevance 0.30
Following desensitization of PAR1 and PAR4, calcium signals in response to thrombin are seen in only a very small number of neurons, far smaller than the proportion in which histological studies had shown expression of PAR3.
Negative_regulation (desensitization) of PAR1 in neurons
7) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.06
Inhalation of nitrous oxide resulted in a marked and significant increase in the MCA FV (from 48+/-9 to 72+/-8 cm/s; mean +/- SD) and a significant decrease in the THRR (from 1.5+/-0.2 to 1.2+/-0.1) and the SA (from 1.0+/-0.1 to 0.8+/-0.1) (P<0.05 for all).
Negative_regulation (decrease) of THRR in MCA
8) Confidence 0.04 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10389799 Disease Relevance 0 Pain Relevance 0.07

General Comments

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