INT82653

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Context Info
Confidence 0.36
First Reported 1999
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.78
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
bladder 4
endothelial cells 1
MCA 1
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 319 100.00 Very High Very High Very High
Inflammatory stimuli 43 96.20 Very High Very High Very High
anesthesia 9 95.44 Very High Very High Very High
substance P 49 94.52 High High
c fibre 5 94.20 High High
agonist 11 91.28 High High
Inflammatory response 54 89.84 High High
cytokine 5 87.52 High High
isoflurane 6 79.76 Quite High
metalloproteinase 3 65.16 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 408 100.00 Very High Very High Very High
Infection 8 97.28 Very High Very High Very High
Microphthalmia 23 89.44 High High
Pressure And Volume Under Development 11 87.20 High High
Overactive Bladder 38 82.84 Quite High
Cystitis 56 76.08 Quite High
Injury 30 73.92 Quite High
Disease Progression 2 66.40 Quite High
Carcinoma 36 57.84 Quite High
Interstitial Cystitis 9 51.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human vascular endothelial cells both thrombin and PAR1-AP elicited gene regulation via E-box signaling [62].
Regulation (regulation) of PAR1 in endothelial cells
1) Confidence 0.36 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.49 Pain Relevance 0.20
Urothelial PAR2 and, to a lesser extent, PAR1 are down-regulated in acute inflammation whereas PAR3 and PAR4 are up-regulated [27].
Regulation (regulated) of PAR1 associated with inflammation
2) Confidence 0.29 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.73 Pain Relevance 0.36
Values of THRR were 1.14 +/- 0.03 (mean +/- SD), 1.15 +/- 0.04, and 1.12 +/- 0.03 during baseline, 1.0, and 2.0 MAC sevoflurane anesthesia, respectively.
Regulation (Values) of THRR associated with anesthesia
3) Confidence 0.23 Published 2001 Journal Masui Section Abstract Doc Link 11797358 Disease Relevance 0 Pain Relevance 0.75
This work indicates an overriding participation of PAR1 receptors in bladder inflammation, provides a working model for the involvement of a network of transcripts downstream of PAR1 activation, and evokes testable hypotheses regarding the regulation of PAR.
Regulation (participation) of PAR1 in bladder associated with inflammation
4) Confidence 0.17 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.56 Pain Relevance 0.23
Our results reveal an overriding participation of PAR1 in bladder inflammation, provide a working model for the involvement of downstream signaling, and evoke testable hypotheses regarding the role of PARs in bladder inflammation.
Regulation (participation) of PAR1 in bladder associated with inflammation
5) Confidence 0.17 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1853108 Disease Relevance 0.93 Pain Relevance 0.46
The combination of cDNA array results and genomic networks reveals an overriding participation of PAR1 in bladder inflammation, provides a working model for the involvement of downstream signaling, and evokes testable hypotheses regarding the transcriptome downstream of PAR1 activation.
Regulation (participation) of PAR1 in bladder associated with inflammation
6) Confidence 0.17 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1853107 Disease Relevance 0.72 Pain Relevance 0.39
This work indicates an overriding participation of PAR1 receptors in bladder inflammation, provides a working model for the involvement of a network of transcripts downstream of PAR1 activation, and evokes testable hypotheses regarding the regulation of PAR.
Regulation (participation) of PAR1 in bladder associated with inflammation
7) Confidence 0.17 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.36 Pain Relevance 0.18
Breathing 100% oxygen did not change MCA FV, THRR, or SA.
Neg (not) Regulation (change) of THRR in MCA
8) Confidence 0.02 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10389799 Disease Relevance 0 Pain Relevance 0.06

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