INT82669

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Context Info
Confidence 0.43
First Reported 1999
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
cerebral cortex 2
Pnoc (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 15 100.00 Very High Very High Very High
qutenza 1 99.52 Very High Very High Very High
substance P 3 98.94 Very High Very High Very High
antagonist 4 98.48 Very High Very High Very High
cerebral cortex 1 98.40 Very High Very High Very High
electroacupuncture 7 98.32 Very High Very High Very High
Neuropathic pain 5 97.52 Very High Very High Very High
Hyperalgesia 4 96.44 Very High Very High Very High
Substantia nigra 1 91.32 High High
Raphe magnus 6 90.84 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 5 97.52 Very High Very High Very High
Hyperalgesia 7 96.44 Very High Very High Very High
Injury 1 87.36 High High
Urological Neuroanatomy 2 81.96 Quite High
Pain 2 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A weak level of prepronociceptin messenger RNA expression was present in some areas, such as the cerebral cortex, endopiriform cortex, hippocampal formation, medial amygdaloid nucleus, anterior hypothalamic area, medial mammillary hypothalamic nuclei, retrorubral field and substantia nigra pars compacta.
Negative_regulation (level) of Gene_expression (expression) of prepronociceptin in cerebral cortex associated with substantia nigra and cerebral cortex
1) Confidence 0.43 Published 1999 Journal Neuroscience Section Abstract Doc Link 10391477 Disease Relevance 0.08 Pain Relevance 0.55
Pretreatment with i.t. substance P antiserum and i.t. capsaicin resulted in a complete block of the reduced threshold produced by nociceptin.
Negative_regulation (block) of Gene_expression (produced) of nociceptin associated with qutenza, orphanin and substance p
2) Confidence 0.29 Published 1999 Journal Brain Res. Section Abstract Doc Link 10546991 Disease Relevance 0.54 Pain Relevance 1.22
The results showed that expression of ppOFQ mRNA decreased and OFQ immunoreactivity increased after EA treatment in the neuropathic pain rats.
Negative_regulation (decreased) of Gene_expression (expression) of ppOFQ associated with neuropathic pain and electroacupuncture
3) Confidence 0.00 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 15249116 Disease Relevance 0.57 Pain Relevance 1.48

General Comments

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