INT82684

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 25.67
Pain Relevance 11.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
platelet 7
endothelial cell 4
plasma 2
coronary artery 1
Nerve 1
Pecam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 287 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 162 100.00 Very High Very High Very High
Endogenous opioid 148 99.80 Very High Very High Very High
analgesia 226 99.08 Very High Very High Very High
Angina 105 96.60 Very High Very High Very High
cva 32 96.44 Very High Very High Very High
ischemia 28 96.20 Very High Very High Very High
Opioid 510 92.88 High High
Pain 164 92.00 High High
antinociception 148 87.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 304 100.00 Very High Very High Very High
Adhesions 280 100.00 Very High Very High Very High
Skin Cancer 48 99.90 Very High Very High Very High
Cancer 80 99.76 Very High Very High Very High
Hemangiosarcoma 46 99.52 Very High Very High Very High
Acute Coronary Syndrome 30 99.28 Very High Very High Very High
Coronary Artery Disease 30 99.28 Very High Very High Very High
Myocardial Infarction 134 98.88 Very High Very High Very High
Angina 17 96.60 Very High Very High Very High
Cv General 3 Under Development 104 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Nerve root injury in the rat produced increased spinal major histocompatibility complex Class II, cluster determinant 4, ICAM-1, and PECAM-1 immunoreactivity and increased bilateral sensitivity to tactile stimuli.
Positive_regulation (increased) of PECAM-1 in Nerve
1) Confidence 0.49 Published 2002 Journal Spine Section Body Doc Link 12163719 Disease Relevance 0 Pain Relevance 0
Increased soluble platelet/endothelial cell adhesion molecule-1 in the early stages of acute coronary syndromes.
Positive_regulation (Increased) of platelet/endothelial cell adhesion molecule-1 in endothelial cell associated with acute coronary syndrome and adhesions
2) Confidence 0.44 Published 2003 Journal Int. J. Cardiol. Section Title Doc Link 12957760 Disease Relevance 1.70 Pain Relevance 0.63
The mechanism of the protection may involve a reduction in circulating TNF-alpha during a critical 3-hour reperfusion interval and reduction in spinal cord endothelial PECAM-1 upregulation.


Positive_regulation (upregulation) of PECAM-1 in spinal cord
3) Confidence 0.38 Published 2002 Journal J. Vasc. Surg. Section Body Doc Link 12021717 Disease Relevance 0 Pain Relevance 0
We assayed platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), intercellular adhesion molecule-1 (ICAM-1, CD54), and P-selectin (CD62P) in plasma obtained from 20 patients within 3 h after the onset of acute myocardial infarction (AMI); 16 patients with unstable angina pectoris; 20 patients with stable angina pectoris, and 28 controls.
Positive_regulation (assayed) of platelet/endothelial cell adhesion molecule-1 in platelet associated with stable angina pectoris, angina, myocardial infarction and adhesions
4) Confidence 0.36 Published 2003 Journal Int. J. Cardiol. Section Abstract Doc Link 12957760 Disease Relevance 1.55 Pain Relevance 0.56
We assayed platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), intercellular adhesion molecule-1 (ICAM-1, CD54), and P-selectin (CD62P) in plasma obtained from 20 patients within 3 h after the onset of acute myocardial infarction (AMI); 16 patients with unstable angina pectoris; 20 patients with stable angina pectoris, and 28 controls.
Positive_regulation (assayed) of PECAM-1 in platelet associated with stable angina pectoris, angina, myocardial infarction and adhesions
5) Confidence 0.36 Published 2003 Journal Int. J. Cardiol. Section Abstract Doc Link 12957760 Disease Relevance 1.56 Pain Relevance 0.56
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Positive_regulation (upregulated) of platelet-endothelial adhesion molecule-1 in platelet associated with inflammation and adhesions
6) Confidence 0.29 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.71 Pain Relevance 0.92
Upregulation of P-selectin and PECAM-1 and the co-localization of L-selectin and beta-endorphin in immunocytes suggest an important role of these adhesion molecules for the recruitment of immunocytes containing beta-endorphin to sites of painful inflammation.
Positive_regulation (Upregulation) of PECAM-1 associated with pain, inflammation and adhesions
7) Confidence 0.26 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10900350 Disease Relevance 0.67 Pain Relevance 0.48
P-selectin and PECAM-1 were constitutively expressed on endothelia of noninflamed lymph nodes and subcutaneous tissue and were upregulated in inflammation. beta-endorphin positive cells expressed L-selectin in lymph nodes and subcutaneous tissue.
Positive_regulation (upregulated) of PECAM-1 in endothelia associated with inflammation
8) Confidence 0.26 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10900350 Disease Relevance 0.59 Pain Relevance 0.48
Increased plasma PECAM-1 may serve as a useful marker in the early detection of patients with AMI.
Positive_regulation (Increased) of PECAM-1 in plasma associated with myocardial infarction
9) Confidence 0.24 Published 1999 Journal Cardiology Section Abstract Doc Link 10393398 Disease Relevance 0.91 Pain Relevance 0.41
However, while the exact role of these adhesion molecules in endogenous opioid analgesia remains to be elucidated, results indicate that PECAM-1 is not required for endogenous opioid analgesia (Machelska et al 2004).
Neg (not) Positive_regulation (required) of PECAM-1 associated with endogenous opioid, adhesions and analgesia
10) Confidence 0.24 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.72 Pain Relevance 1.09
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Positive_regulation (upregulated) of PECAM-1 in platelet associated with inflammation and adhesions
11) Confidence 0.22 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.70 Pain Relevance 0.86
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Positive_regulation (increased) of platelet-endothelial adhesion molecule-1 in platelet associated with inflammation and adhesions
12) Confidence 0.21 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.72 Pain Relevance 0.94
Immunohistochemical staining was positive for the endothelial markers CD31, CD34, CK(+), and vim(+).
Positive_regulation (positive) of CD31
13) Confidence 0.17 Published 2009 Journal J. Pediatr. Hematol. Oncol. Section Abstract Doc Link 19636267 Disease Relevance 0.75 Pain Relevance 0.09
We assayed platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), intercellular adhesion molecule-1 (ICAM-1, CD54), and P-selectin (CD62P) in plasma obtained from 20 patients within 3 h after the onset of acute myocardial infarction (AMI); 16 patients with unstable angina pectoris; 20 patients with stable angina pectoris, and 28 controls.
Positive_regulation (assayed) of CD31 in platelet associated with stable angina pectoris, angina, myocardial infarction and adhesions
14) Confidence 0.16 Published 2003 Journal Int. J. Cardiol. Section Abstract Doc Link 12957760 Disease Relevance 1.56 Pain Relevance 0.56
Increased soluble platelet/endothelial cell adhesion molecule-1 in the early stages of acute coronary syndromes.
Positive_regulation (Increased) of platelet/endothelial cell adhesion molecule-1 in platelet associated with acute coronary syndrome and adhesions
15) Confidence 0.15 Published 2003 Journal Int. J. Cardiol. Section Title Doc Link 12957760 Disease Relevance 1.70 Pain Relevance 0.63
We assayed platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), intercellular adhesion molecule-1 (ICAM-1, CD54), and P-selectin (CD62P) in plasma obtained from 20 patients within 3 h after the onset of acute myocardial infarction (AMI); 16 patients with unstable angina pectoris; 20 patients with stable angina pectoris, and 28 controls.
Positive_regulation (assayed) of PECAM-1 in endothelial cell associated with stable angina pectoris, angina, myocardial infarction and adhesions
16) Confidence 0.12 Published 2003 Journal Int. J. Cardiol. Section Abstract Doc Link 12957760 Disease Relevance 1.56 Pain Relevance 0.56
We assayed platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), intercellular adhesion molecule-1 (ICAM-1, CD54), and P-selectin (CD62P) in plasma obtained from 20 patients within 3 h after the onset of acute myocardial infarction (AMI); 16 patients with unstable angina pectoris; 20 patients with stable angina pectoris, and 28 controls.
Positive_regulation (assayed) of platelet/endothelial cell adhesion molecule-1 in endothelial cell associated with stable angina pectoris, angina, myocardial infarction and adhesions
17) Confidence 0.12 Published 2003 Journal Int. J. Cardiol. Section Abstract Doc Link 12957760 Disease Relevance 1.55 Pain Relevance 0.56
The tumor was composed of epithelioid cells, which showed positive staining for cytokeratin and expression of the common endothelial markers CD31, CD34, and von Willebrand factor.
Positive_regulation (staining) of CD31 associated with cancer
18) Confidence 0.12 Published 1999 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 10555012 Disease Relevance 0.84 Pain Relevance 0.08
Immunohistochemical staining was performed and tumor cells were positive for CD31, CD34, and vimentin (Figure 4b), whereas negative for factor antigen, CD117, and S-100.
Positive_regulation (positive) of CD31 associated with cancer
19) Confidence 0.10 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1242259 Disease Relevance 1.17 Pain Relevance 0.07
Furthermore, we found significantly elevated serum levels for sICAM-1 after PTCA and for sPECAM-1 in the tPA group compared with controls and with both of the other therapy groups.
Positive_regulation (elevated) of sPECAM-1 associated with percutaneous transluminal coronary angioplasty
20) Confidence 0.09 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.58 Pain Relevance 0.22

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