INT82685

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Context Info
Confidence 0.76
First Reported 1999
Last Reported 2011
Negated 4
Speculated 3
Reported most in Abstract
Documents 36
Total Number 39
Disease Relevance 27.95
Pain Relevance 9.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
platelet 9
endothelial cells 6
capillary 2
plasma 1
bone marrow 1
Pecam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 286 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 135 99.82 Very High Very High Very High
Spinal cord 54 99.78 Very High Very High Very High
ischemia 48 99.24 Very High Very High Very High
adenocard 13 98.10 Very High Very High Very High
cytokine 71 97.68 Very High Very High Very High
analgesia 171 97.08 Very High Very High Very High
cva 31 94.96 High High
Cannabinoid receptor 3 94.96 High High
opioid receptor 286 94.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 298 100.00 Very High Very High Very High
Adhesions 220 100.00 Very High Very High Very High
Skin Cancer 54 99.90 Very High Very High Very High
Cancer 209 99.76 Very High Very High Very High
Spinal Cord Ischemia 9 99.72 Very High Very High Very High
Shock 6 99.64 Very High Very High Very High
Hemangiosarcoma 78 99.52 Very High Very High Very High
Htlv Types I And Ii 12 98.44 Very High Very High Very High
Hepatocellular Cancer 73 98.32 Very High Very High Very High
Apoptosis 48 97.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: In the present study the authors investigated the role of neuroimmune activation using immunocytochemistry to detect expression of major histocompatibility complex Class II, cluster determinant 4, intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cellular adhesion molecule-1 (PECAM-1).
Gene_expression (expression) of platelet endothelial cellular adhesion molecule-1 in platelet
1) Confidence 0.76 Published 2002 Journal Spine Section Body Doc Link 12163719 Disease Relevance 0.09 Pain Relevance 0
OBJECTIVES: In the present study the authors investigated the role of neuroimmune activation using immunocytochemistry to detect expression of major histocompatibility complex Class II, cluster determinant 4, intracellular adhesion molecule-1 (ICAM-1), and platelet endothelial cellular adhesion molecule-1 (PECAM-1).
Gene_expression (expression) of PECAM-1 in platelet
2) Confidence 0.76 Published 2002 Journal Spine Section Body Doc Link 12163719 Disease Relevance 0.09 Pain Relevance 0
We hypothesized that ATL-146e reduces cytokine production during spinal cord reperfusion, curtailing inflammation and decreasing spinal cord capillary platelet-endothelial cell adhesion molecule-1 (PECAM-1) expression.
Gene_expression (expression) of PECAM-1 in capillary associated with inflammation, htlv types i and ii, adhesions, spinal cord and cytokine
3) Confidence 0.72 Published 2002 Journal J. Vasc. Surg. Section Abstract Doc Link 12021717 Disease Relevance 1.34 Pain Relevance 0.81
We hypothesized that ATL-146e reduces cytokine production during spinal cord reperfusion, curtailing inflammation and decreasing spinal cord capillary platelet-endothelial cell adhesion molecule-1 (PECAM-1) expression.
Gene_expression (expression) of platelet-endothelial cell adhesion molecule-1 in capillary associated with inflammation, htlv types i and ii, adhesions, spinal cord and cytokine
4) Confidence 0.63 Published 2002 Journal J. Vasc. Surg. Section Abstract Doc Link 12021717 Disease Relevance 1.36 Pain Relevance 0.81
Adenosine A2A analogue ATL-146e reduces systemic tumor necrosing factor-alpha and spinal cord capillary platelet-endothelial cell adhesion molecule-1 expression after spinal cord ischemia.
Gene_expression (expression) of platelet-endothelial cell adhesion molecule-1 in endothelial cell associated with adenocard, cancer, ischemia, htlv types i and ii, adhesions and spinal cord
5) Confidence 0.63 Published 2002 Journal J. Vasc. Surg. Section Title Doc Link 12021717 Disease Relevance 1.35 Pain Relevance 0.79
The prolongation of the healing in diabetic animals was associated with an increase in gastric mucosal expression and release of TNFalpha, interleukin-1 beta (IL-1 beta), suppression of the vascular endothelial growth factor (VEGF), platelet endothelial cell adhesion molecule-1 (PECAM-1) and the mucosal overexpression of heat shock protein 70 (HSP 70).
Gene_expression (overexpression) of platelet endothelial cell adhesion molecule-1 in endothelial cell associated with diabetes mellitus, shock and adhesions
6) Confidence 0.62 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.50 Pain Relevance 0.11
Administration of insulin reversed the delay in ulcer healing and significantly decreased the expression of IL-1 beta and TNF-alpha, while producing the rise in the expression of VEGF and PECAM.
Gene_expression (expression) of PECAM associated with ulcers
7) Confidence 0.62 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.57 Pain Relevance 0.11
The prolongation of the healing in diabetic animals was associated with an increase in gastric mucosal expression and release of TNFalpha, interleukin-1 beta (IL-1 beta), suppression of the vascular endothelial growth factor (VEGF), platelet endothelial cell adhesion molecule-1 (PECAM-1) and the mucosal overexpression of heat shock protein 70 (HSP 70).
Gene_expression (overexpression) of PECAM in endothelial cell associated with diabetes mellitus, shock and adhesions
8) Confidence 0.62 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.43 Pain Relevance 0.11
RESULTS: Nerve root injury in the rat produced increased spinal major histocompatibility complex Class II, cluster determinant 4, ICAM-1, and PECAM-1 immunoreactivity and increased bilateral sensitivity to tactile stimuli.
Gene_expression (produced) of PECAM-1 in Nerve
9) Confidence 0.59 Published 2002 Journal Spine Section Body Doc Link 12163719 Disease Relevance 0 Pain Relevance 0
Moreover, angiogenesis was evaluated by the measurement of both hemoglobin content and CD31 protein expression.
Gene_expression (expression) of CD31
10) Confidence 0.58 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 19931394 Disease Relevance 0.56 Pain Relevance 0.50
RESULTS: Interleukin-1 receptor type I was found on sensory (CGRP-IR) and sympathetic (NPY-IR) nerve fibres and on blood vessels (CD31- and CD34-IR) in the dental pulp.
Gene_expression (found) of CD31 in dental pulp
11) Confidence 0.47 Published 2009 Journal Int Endod J Section Body Doc Link 19732182 Disease Relevance 0.13 Pain Relevance 0
Immunohistochemical staining was negative for the endothelial markers (CD31, CD34, and factor VIII-related antigen) and positive using cytokeratin antibodies (AE1/AE3 and 34 betaE12).
Neg (negative) Gene_expression (negative) of CD31
12) Confidence 0.45 Published 2005 Journal Am J Dermatopathol Section Abstract Doc Link 15798440 Disease Relevance 0.78 Pain Relevance 0.09
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Gene_expression (expression) of PECAM-1 in platelet associated with inflammation and adhesions
13) Confidence 0.37 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.71 Pain Relevance 0.89
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Gene_expression (expression) of platelet-endothelial adhesion molecule-1 in platelet associated with inflammation and adhesions
14) Confidence 0.32 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.72 Pain Relevance 0.94
P-selectin and PECAM-1 were constitutively expressed on endothelia of noninflamed lymph nodes and subcutaneous tissue and were upregulated in inflammation. beta-endorphin positive cells expressed L-selectin in lymph nodes and subcutaneous tissue.
Gene_expression (expressed) of PECAM-1 in endothelia associated with inflammation
15) Confidence 0.29 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10900350 Disease Relevance 0.58 Pain Relevance 0.46
In this study, the expression of L-, P-, E-selectin and platelet-endothelial adhesion molecule-1 (PECAM-1) in relation to beta-endorphin expression was analyzed by immunohistochemistry in inflamed tissues.
Spec (analyzed) Gene_expression (expression) of platelet-endothelial adhesion molecule-1 in platelet associated with adhesions
16) Confidence 0.29 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10900350 Disease Relevance 0.57 Pain Relevance 0.39
In this study, the expression of L-, P-, E-selectin and platelet-endothelial adhesion molecule-1 (PECAM-1) in relation to beta-endorphin expression was analyzed by immunohistochemistry in inflamed tissues.
Spec (analyzed) Gene_expression (expression) of PECAM-1 in platelet associated with adhesions
17) Confidence 0.29 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10900350 Disease Relevance 0.57 Pain Relevance 0.39
The PeCAM building is divided into three major wings.
Gene_expression (building) of PeCAM in wings
18) Confidence 0.29 Published 2010 Journal CytoJournal Section Body Doc Link PMC2895872 Disease Relevance 0.09 Pain Relevance 0.03
Indirect immunofluorescence for detection of CD31 (PharMingen, USA), was performed using rabbit anti-rat PECAM-1 antibody by a standard protocol as given by the manufacturer.
Gene_expression (detection) of CD31
19) Confidence 0.28 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0 Pain Relevance 0
These adhesion molecules comprise the carbohydrate binding selectins, immunoglobulins (Ig) such as ICAM and PECAM, and the integrin family of ?
Gene_expression (comprise) of PECAM associated with adhesions
20) Confidence 0.28 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 1.05 Pain Relevance 0.83

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