INT82702

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Context Info
Confidence 0.45
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.08
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (LDLR) small molecule metabolic process (LDLR) plasma membrane (LDLR)
lipid metabolic process (LDLR) lysosome (LDLR)
Anatomy Link Frequency
blood 2
LDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 3 96.60 Very High Very High Very High
Paracetamol 2 90.28 High High
antagonist 2 85.96 High High
cINOD 10 85.84 High High
agonist 2 85.44 High High
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 22 98.76 Very High Very High Very High
INFLAMMATION 5 85.44 High High
Increased Venous Pressure Under Development 5 84.76 Quite High
Nephrotoxicity 1 83.20 Quite High
Hepatocellular Cancer 1 73.60 Quite High
Disease 56 65.36 Quite High
Atherosclerosis 1 59.16 Quite High
Recurrence 105 50.00 Quite Low
Chronic Renal Failure 29 5.00 Very Low Very Low Very Low
Renal Disease 29 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, flufenamic acid and indomethacin were both found to increase the synthesis of mRNA of the LDL receptor with a subsequent increase of LDL receptor protein.
Positive_regulation (increase) of Positive_regulation (increase) of LDL receptor
1) Confidence 0.45 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10395027 Disease Relevance 0.26 Pain Relevance 0.62
For example, statins modulate activation of the class-I transcription factor sterol responsive element-binding protein (SREBP), whose target genes including hydroxyl-methyl-glutaryl acetyl Coenzyme-A (HMG-CoA) reductase, HMG-CoA synthase, and the low-density lipoprotein receptor, all of which are involved in cholesterol and fatty acid metabolism.
Positive_regulation (activation) of Positive_regulation (activation) of low-density lipoprotein receptor
2) Confidence 0.06 Published 2002 Journal Int. J. Cardiol. Section Abstract Doc Link 12419552 Disease Relevance 0.22 Pain Relevance 0.17
For example, statins modulate activation of the class-I transcription factor sterol responsive element-binding protein (SREBP), whose target genes including hydroxyl-methyl-glutaryl acetyl Coenzyme-A (HMG-CoA) reductase, HMG-CoA synthase, and the low-density lipoprotein receptor, all of which are involved in cholesterol and fatty acid metabolism.
Positive_regulation (including) of Positive_regulation (involved) of low-density lipoprotein receptor
3) Confidence 0.06 Published 2002 Journal Int. J. Cardiol. Section Abstract Doc Link 12419552 Disease Relevance 0.22 Pain Relevance 0.17
The rationale behind maintaining high CsA blood concentration is to overcome the effect of high serum levels of low-density lipoprotein (LDL) (secondary to recurrent NS), which binds CsA and is further responsible for low levels of free available CsA.
Positive_regulation (overcome) of Positive_regulation (levels) of low-density lipoprotein in blood associated with disorder of lipid metabolism
4) Confidence 0.04 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 0.38 Pain Relevance 0

General Comments

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