INT82709

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Context Info
Confidence 0.34
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 3.41
Pain Relevance 8.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
head 2
hepatocytes 1
striatum 1
urine 1
Slc37a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 183 100.00 Very High Very High Very High
Serotonin 36 100.00 Very High Very High Very High
noradrenaline 9 100.00 Very High Very High Very High
fluoxetine 15 99.72 Very High Very High Very High
adenocard 1 99.72 Very High Very High Very High
Enkephalin 4 99.66 Very High Very High Very High
antidepressant 22 99.48 Very High Very High Very High
depression 11 99.28 Very High Very High Very High
antagonist 8 98.96 Very High Very High Very High
Nucleus accumbens 12 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 3 99.86 Very High Very High Very High
Crystal Associated Disease 13 99.38 Very High Very High Very High
Disease 12 99.38 Very High Very High Very High
Depression 13 99.28 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 39 98.88 Very High Very High Very High
Toxicity 43 94.76 High High
Hyperkinesis 1 94.48 High High
Targeted Disruption 24 82.32 Quite High
Diabetes Mellitus 9 76.72 Quite High
Hypertension 21 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single administration of 40 mg/kg (i.p.) of methamphetamine caused a loss of dopamine transporter in the striatum of albino Swiss (CD-1) mouse for at least 3 weeks.
Negative_regulation (loss) of transporter in striatum associated with dopamine
1) Confidence 0.34 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10395030 Disease Relevance 0 Pain Relevance 0.36
Reversal by [D-Ala2,D-Leu5]enkephalin of the dopamine transporter loss caused by methamphetamine.
Negative_regulation (loss) of transporter associated with dopamine and enkephalin
2) Confidence 0.25 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10395030 Disease Relevance 0 Pain Relevance 0.41
The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls.
Negative_regulation (inhibitor) of transporter in head associated with desipramine, antidepressant, depression, noradrenaline, serotonin and fluoxetine
3) Confidence 0.21 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16530230 Disease Relevance 0.09 Pain Relevance 0.44
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.
Negative_regulation (inhibits) of transporter associated with antidepressant, noradrenaline and serotonin
4) Confidence 0.21 Published 2006 Journal Neuropharmacology Section Title Doc Link 16530230 Disease Relevance 0.08 Pain Relevance 0.48
The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls.
Negative_regulation (inhibitor) of transporter in head associated with desipramine, antidepressant, depression, noradrenaline, serotonin and fluoxetine
5) Confidence 0.21 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16530230 Disease Relevance 0.09 Pain Relevance 0.44
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.
Negative_regulation (inhibits) of transporter associated with antidepressant, noradrenaline and serotonin
6) Confidence 0.21 Published 2006 Journal Neuropharmacology Section Title Doc Link 16530230 Disease Relevance 0.08 Pain Relevance 0.48
Fluoxetine, a serotonin transporter (SERT) inhibitor, produced CPP in DD, but not control mice, suggesting that serotonin mediates cocaine CPP in DD mice.
Negative_regulation (inhibitor) of transporter associated with serotonin, cocaine and fluoxetine
7) Confidence 0.19 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18003826 Disease Relevance 0 Pain Relevance 1.11
Additionally, fluoxetine, a serotonin transporter (SERT) inhibitor, also had no effect on these parameters.
Negative_regulation (inhibitor) of transporter associated with serotonin and fluoxetine
8) Confidence 0.15 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12006604 Disease Relevance 0.15 Pain Relevance 1.21
Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter.
Negative_regulation (lacking) of transporter associated with antidepressant and serotonin
9) Confidence 0.13 Published 2002 Journal Neuropsychopharmacology Section Title Doc Link 12464448 Disease Relevance 0.08 Pain Relevance 0.36
Inhibition of the serotonin transporter (5-HTT) is a principal initial target of many antidepressants.
Negative_regulation (Inhibition) of transporter associated with antidepressant and serotonin
10) Confidence 0.13 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12464448 Disease Relevance 0.05 Pain Relevance 0.21
Although conjugation of sunitinib with glutathione is not reported in the literature, sunitinib is a substrate and a competitive inhibitor of a glutathione-conjugate transporter and may decrease the availability of glutathione in the hepatocytes [39].
Negative_regulation (inhibitor) of transporter in hepatocytes
11) Confidence 0.04 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.25 Pain Relevance 0.47
By using mice lacking the dopamine transporter (DAT-KO mice) [9], [11], we have developed a model of acute dopamine deficiency, DDD mice (dopamine-deficient DAT-KO mice) [12], [13].
Negative_regulation (lacking) of transporter associated with dopamine
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.16 Pain Relevance 0.66
Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter.
Negative_regulation (inhibitors) of transporter associated with disease and serotonin
13) Confidence 0.04 Published 2010 Journal Chem. Pharm. Bull. Section Title Doc Link 20190429 Disease Relevance 0.54 Pain Relevance 0.36
Since patients of Alzheimer's disease often exhibit depression as well as memory impairment, dual inhibitors of AChE and serotonin transporter (SERT) would be a better therapeutic method.
Negative_regulation (inhibitors) of transporter associated with cognitive disorder, depression, disease and serotonin
14) Confidence 0.04 Published 2010 Journal Chem. Pharm. Bull. Section Abstract Doc Link 20190429 Disease Relevance 0.56 Pain Relevance 0.31
In addition, ethanol also interferes with adenosine re-uptake by inhibiting the equilibrative nucleoside transporter ENT1, although it is not clear if this plays a role in ethanol-induced dopamine release [36].
Negative_regulation (inhibiting) of transporter associated with dopamine and adenocard
15) Confidence 0.03 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0.07 Pain Relevance 0.82
In contrast, in the same animal model, it was shown that nisoxitine, a norepinephrine transporter blocker, does not affect locomotor hyperactivity.
Negative_regulation (blocker) of transporter associated with attention deficit hyperactivity disorder
16) Confidence 0.02 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.66 Pain Relevance 0.39
Uricosuric drugs, which are used to treat gout, reduce serum urate levels by inhibiting a urate transporter that reabsorbs urate from urine.


Negative_regulation (inhibiting) of transporter in urine associated with crystal associated disease
17) Confidence 0.01 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2561076 Disease Relevance 0.53 Pain Relevance 0.07

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