INT82719

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Context Info
Confidence 0.08
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 9.55
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (ASF1A) nucleus (ASF1A)
Anatomy Link Frequency
cartilage 1
CII 1
ASF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 468 100.00 Very High Very High Very High
rheumatoid arthritis 180 97.72 Very High Very High Very High
Inflammation 156 89.64 High High
spondylitis 6 77.48 Quite High
Pain 18 74.80 Quite High
Dysuria 1 65.52 Quite High
Buprenorphine 6 49.20 Quite Low
opiate 6 46.96 Quite Low
Spinal cord 1 25.00 Low Low
medulla 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Arthritis 540 100.00 Very High Very High Very High
Muscle Weakness 3 99.40 Very High Very High Very High
Immunization 36 99.12 Very High Very High Very High
Rheumatoid Arthritis 180 97.72 Very High Very High Very High
Multiple Sclerosis 78 95.84 Very High Very High Very High
Congenital Anomalies 2 95.68 Very High Very High Very High
Hyperplasia 24 94.76 High High
Disease 156 93.80 High High
INFLAMMATION 132 89.64 High High
Sprains And Strains 48 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In about half of randomly selected animals from the outbred colony of genetically typed rhesus monkeys at our institute, CIA could be induced.
Positive_regulation (induced) of CIA associated with arthritis
1) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.51 Pain Relevance 0.52
Selection of A26- monkeys thus allows reproducible induction of CIA in >95% of animals.
Positive_regulation (induction) of CIA associated with arthritis
2) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.00 Pain Relevance 0.29
After a small increase of CRP in the first week after CIA induction without clinical signs, a second increase is observed in CIA-sensitive animals, which is more pronounced and precedes the onset of clinical arthritis.
Positive_regulation (induction) of CIA associated with arthritis
3) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.24 Pain Relevance 0.53
CIA is induced in rhesus monkeys by immunization with 3 to 5 mg bovine collagen type II (b-CII) dissolved in 0.5 ml 0.1 M acetic acid and emulsified in an equal volume of complete Freund's adjuvant (CFA).
Positive_regulation (induced) of CIA in CII associated with immunization and arthritis
4) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.43 Pain Relevance 0.52
The anti-GM1 IgG titer was transiently elevated in the patient's serum after gamma-immunoglobulin therapy.
Positive_regulation (elevated) of anti-GM1 IgG
5) Confidence 0.07 Published 1999 Journal No To Shinkei Section Abstract Doc Link 10396755 Disease Relevance 1.23 Pain Relevance 0.07
These preceded the dramatic destruction of cartilage and bone in advanced CIA (Fig. 3, bottom left).


Positive_regulation (advanced) of CIA in cartilage associated with arthritis
6) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.44 Pain Relevance 0.50
Predictably, the incidence and clinical presentation of collagen-induced arthritis (CIA) in a random sample (more than 50) of the large, outbred rhesus monkey colony at our institute (more than 1,200 animals) appeared heterogeneous, as is observed for human RA.
Positive_regulation (induced) of CIA associated with rheumatoid arthritis and arthritis
7) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175046 Disease Relevance 1.70 Pain Relevance 0.56

General Comments

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