INT82722

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.74
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 6
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 25 100.00 Very High Very High Very High
alcohol 25 79.52 Quite High
tolerance 6 56.60 Quite High
fibrosis 4 49.60 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 98.96 Very High Very High Very High
Overdose 2 98.40 Very High Very High Very High
Hepatotoxicity 10 98.16 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 73 96.60 Very High Very High Very High
Stress 28 95.24 Very High Very High Very High
Fatty Liver 34 95.04 Very High Very High Very High
Necrosis 2 91.72 High High
Obesity 17 91.52 High High
Diabetes Mellitus 1 90.32 High High
Injury 12 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oral treatment of mice with BA resulted in a significant decrease in AP-induced CYP2E1 activity together with its inhibition of AP-induced CYP2EI expression.
Negative_regulation (decrease) of Positive_regulation (induced) of CYP2E1 associated with paracetamol
1) Confidence 0.59 Published 2003 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 14686800 Disease Relevance 0.23 Pain Relevance 1.01
S-allylmercaptocysteine significantly suppressed hepatic cytochrome P450 2E1 (CYP2E1) activity and induction of inducible 70-kDa heat shock protein, a marker of acetaminophen arylation of protein.
Negative_regulation (suppressed) of Positive_regulation (induction) of CYP2E1 associated with paracetamol and shock
2) Confidence 0.43 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11755151 Disease Relevance 0.44 Pain Relevance 0.76
Increases of CYP2E1 and its mRNA prevail in the perivenular zone, the area of maximal liver damage.
Negative_regulation (prevail) of Positive_regulation (Increases) of CYP2E1 in liver associated with hepatotoxicity
3) Confidence 0.40 Published 2004 Journal Drug Metab. Rev. Section Abstract Doc Link 15554233 Disease Relevance 1.76 Pain Relevance 0.05
CONCLUSIONS: These results suggest that hepatic steatosis elicited by the "Western-style" diet attenuated APAP-induced hepatotoxicity by inhibiting CYP2E1 induction and by minimizing sinusoidal endothelial cell injury, leading to protection of liver microcirculation.


Negative_regulation (inhibiting) of Positive_regulation (induction) of CYP2E1 in liver
4) Confidence 0.40 Published 2006 Journal Microcirculation Section Body Doc Link 16393943 Disease Relevance 0.05 Pain Relevance 0
Increases of CYP2E1 and its mRNA prevail in the perivenular zone, the area of maximal liver damage.
Negative_regulation (prevail) of Positive_regulation (Increases) of CYP2E1 in liver associated with hepatotoxicity
5) Confidence 0.39 Published 1999 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 10397283 Disease Relevance 0.48 Pain Relevance 0.16
in response to increased fatty acid load, impaired electron transport, and/or increased CYP2E1 in the HFD group would effectively decrease free NO concentrations in the cell via enhanced formation of ONOO?
Negative_regulation (impaired) of Positive_regulation (increased) of CYP2E1
6) Confidence 0.38 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.39 Pain Relevance 0.03
in response to increased fatty acid load, impaired electron transport, and/or increased CYP2E1 in the HFD group would effectively decrease free NO concentrations in the cell via enhanced formation of ONOO?
Neg (NO) Negative_regulation (decrease) of Positive_regulation (increased) of CYP2E1
7) Confidence 0.38 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2637578 Disease Relevance 0.39 Pain Relevance 0

General Comments

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