INT82731

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Context Info
Confidence 0.56
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.41
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1a) DNA binding (Cacna1a) transmembrane transport (Cacna1a)
cytoplasm (Cacna1a) cell death (Cacna1a) nucleus (Cacna1a)
Anatomy Link Frequency
dorsal root ganglion 2
Cacna1a (Mus musculus)
Pain Link Frequency Relevance Heat
Migraine 18 100.00 Very High Very High Very High
Analgesic 4 99.92 Very High Very High Very High
dorsal root ganglion 11 99.78 Very High Very High Very High
Nerve growth factor 12 99.04 Very High Very High Very High
adenocard 2 98.52 Very High Very High Very High
sodium channel 6 97.38 Very High Very High Very High
agonist 6 97.20 Very High Very High Very High
conotoxin 2 96.68 Very High Very High Very High
tail-flick 1 87.48 High High
intrathecal 1 86.96 High High
Disease Link Frequency Relevance Heat
Migraine With Aura 11 100.00 Very High Very High Very High
Ganglion Cysts 11 99.78 Very High Very High Very High
Epilepsy 2 99.60 Very High Very High Very High
Paresis 1 98.96 Very High Very High Very High
Nociception 5 96.56 Very High Very High Very High
Headache 7 94.96 High High
Disease 2 92.88 High High
Hyperalgesia 4 86.24 High High
Hypertrophy 1 83.80 Quite High
Targeted Disruption 2 77.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcripts of alpha1A, alpha1B, alpha1E, alpha1F, alpha1H, beta3, and beta4 subunits were detected by polymerase-chain reaction (PCR) in the dorsal root ganglion, suggesting the existence of a variety of voltage-dependent Ca2+ channels.
Transcription (Transcripts) of alpha1A in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.56 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11426839 Disease Relevance 0.28 Pain Relevance 0.42
The contribution of alpha-1 and alpha-2 adrenoceptors in peripheral imidazoline and adrenoceptor agonist-induced nociception.
Transcription (contribution) of alpha-1 associated with nociception, analgesic and agonist
2) Confidence 0.23 Published 2006 Journal Anesth. Analg. Section Title Doc Link 16861437 Disease Relevance 0.40 Pain Relevance 1.04
Here we describe a unique FHM family in which two novel allelic missense mutations in the Na,K-ATPase gene ATP1A2 segregate in the proband with hemiplegic migraine.
Transcription (describe) of FHM associated with migraine
3) Confidence 0.20 Published 2007 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 17473835 Disease Relevance 0.76 Pain Relevance 0.62
Two novel amino acid changes p.Arg65Trp and p.Tyr9Asn, in the Na,K-adenosine triphosphatase (ATPase) alpha-2 subunit encoded by the ATP1A2 gene, were found in one FHM family and in the sporadic case, respectively.
Transcription (found) of FHM associated with adenocard and migraine
4) Confidence 0.05 Published 2007 Journal Clin. Genet. Section Abstract Doc Link 17877748 Disease Relevance 0.92 Pain Relevance 0.95
Hybridization signals for sodium channel subunits alphaII and beta2 displayed the most substantial enhancement in hyper-NGF mice, compared to wild-type mice DRG, and mRNA levels for alphaI, NaG, Na6, SNS/PN3, NaN, and beta1 were also greater in hyper-NGF DRG.
Transcription (levels) of alphaI in DRG associated with dorsal root ganglion, nerve growth factor and sodium channel
5) Confidence 0.01 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10397634 Disease Relevance 1.05 Pain Relevance 1.23

General Comments

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