INT82742

Context Info Confidence 0.75 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 10 Disease Relevance 7.06 Pain Relevance 0.44

extracellular space (Tff2) extracellular region (Tff2) structural molecule activity (Tff2)

Anatomy Link Frequency glands 4 fat 2 margin 1 Tff2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Somatostatin 16 100.00 peptic ulcer disease 2 90.96 cytokine 8 88.68 nud 2 88.48 Inflammation 32 88.28 Neuropeptide 2 25.00 cINOD 8 5.00 adenocard 8 5.00

Disease Link Frequency Relevance Heat Ulcers 326 99.20 Stomach Cancer 8 99.04 Metaplasia 296 98.80 Frailty 16 97.32 Cleidocranial Dysplasia 72 95.24 Adenoma 8 93.36 Colon Cancer 8 91.68 Disease 2 90.96 Hyperplasia 50 89.00 Dyspepsia 2 88.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Human MNCs express PSTI, TFF1/pS2, TFF2/SP, and EGF proteins, while rat MNCs express TFF2/SP; the mucin contained in the MNCs is diastase/periodic acid Schiff (D/PAS)-positive and stains with human milk fat globulin (HMFG2).

Gene_expression (express) of TFF2 in fat

1) Confidence 0.75 Published 1999 Journal J. Pathol. Section Abstract Doc Link 10398088 Disease Relevance 0.35 Pain Relevance 0.13

Human MNCs express PSTI, TFF1/pS2, TFF2/SP, and EGF proteins, while rat MNCs express TFF2/SP; the mucin contained in the MNCs is diastase/periodic acid Schiff (D/PAS)-positive and stains with human milk fat globulin (HMFG2).

Gene_expression (express) of TFF2 in fat

2) Confidence 0.75 Published 1999 Journal J. Pathol. Section Abstract Doc Link 10398088 Disease Relevance 0.36 Pain Relevance 0.14

Thus, there was overlap in expression of TFF2, MUC6 and pepsinogen in cells at the base (Figure 5, d-f).

Gene_expression (expression) of TFF2

3) Confidence 0.70 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.88 Pain Relevance 0

The function of TFF2, which is protease resistant and produces mucus/TFF complexes of high viscosity, might be to protect the progenitor zone [29].

Gene_expression (produces) of TFF2

4) Confidence 0.61 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 1.30 Pain Relevance 0.13

No antigen retrieval procedure was used for DCAMKL1, H+/K+-ATPase, PCNA (rabbit IgG), TFF2, HDC, ghrelin or somatostatin staining.

Gene_expression (staining) of TFF2 associated with somatostatin

5) Confidence 0.61 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0 Pain Relevance 0.05

DCAMKL1, PCNA and TFF2 were expressed in different dysplastic cells lining dilated glands near SPEM.

Gene_expression (expressed) of TFF2 in glands associated with metaplasia

6) Confidence 0.54 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2912238 Disease Relevance 1.19 Pain Relevance 0

SPEM evolved and expanded near the dilated glands and segmental expression of TFF2 was found in cells lining the glands (Figure 8b).

Gene_expression (expression) of TFF2 in glands associated with metaplasia

7) Confidence 0.54 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.47 Pain Relevance 0

DCAMKL1 and TFF2 were expressed in dilated glands in this study.

Gene_expression (expressed) of TFF2 in glands

8) Confidence 0.54 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.86 Pain Relevance 0

In the ulcer margin, MUC6 and pepsinogen seem to be coexpressed with TFF2 at the gland base.

Gene_expression (coexpressed) of TFF2 in margin associated with ulcers

9) Confidence 0.54 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 1.21 Pain Relevance 0

TFF2 and DCAMKL1 were expressed in different cells in the dilated glands (Figure 8d, 8e), and PCNA was also expressed in cells other than DCAMKL1 cells, indicating the proliferative nature of the glands (Figure 8f).

Gene_expression (expressed) of TFF2 in glands

10) Confidence 0.54 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0.44 Pain Relevance 0

General Comments

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