INT82744

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2011
Negated 1
Speculated 7
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 2.09
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscles 16
body 2
Myh13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 22 99.24 Very High Very High Very High
fibrosis 22 98.08 Very High Very High Very High
Spinal cord 4 75.00 Quite High
palliative 1 41.04 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 33 100.00 Very High Very High Very High
Overdose 33 99.68 Very High Very High Very High
Xerostomia 22 99.12 Very High Very High Very High
Fibrosis 22 98.08 Very High Very High Very High
Frailty 25 97.56 Very High Very High Very High
Head & Neck Cancer 11 93.32 High High
Weight Loss 11 90.80 High High
Fatigue 22 88.64 High High
Injury 2 79.60 Quite High
Laryngeal Cancer 22 45.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There have not been any previous studies that have focused on the change of the MyHC isoform expression in the laryngeal muscle after X-ray irradiation.
Regulation (change) of Gene_expression (expression) of MyHC isoform in muscle
1) Confidence 0.59 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0 Pain Relevance 0
We examined the change in body weight and the change of the MyHC isoform expression in a murine model according to different radiation doses and over time after irradiation.
Spec (examined) Regulation (change) of Gene_expression (expression) of MyHC isoform in body associated with body weight
2) Confidence 0.59 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0.44 Pain Relevance 0.03
The comparative threshold method was applied to examine the effect of radiation on the MyHC expression in the laryngeal muscles of the SD rats.
Spec (examine) Regulation (effect) of Gene_expression (expression) of MyHC in muscles
3) Confidence 0.59 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0 Pain Relevance 0
Determining the changes of the MyHC isoform expression over time after irradiation
Spec (Determining) Regulation (changes) of Gene_expression (expression) of MyHC isoform
4) Confidence 0.59 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0.15 Pain Relevance 0.08
Compared with Tx only, with Ex or with Trpl, there was a decrease in the number of myofibers expressing type I or IIa isoforms but little change in expression of IIx MyHC.
Neg (little) Regulation (change) of Gene_expression (expression) of IIx MyHC
5) Confidence 0.54 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10398201 Disease Relevance 0.25 Pain Relevance 0.10
According to a study on the change of the MyHC isoform expression in rat leg muscle after irradiation, the expressions of MyHC I and IIa in the plantaris muscle increased after 25 Gy irradiation, but the expressions of MyHC IIb and IIx decreased.
Regulation (change) of Gene_expression (expression) of MyHC isoform in muscle
6) Confidence 0.43 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0 Pain Relevance 0
We did not examine the effect of radiation on the TA expression of MyHC I because it has been reported that the TA muscle expresses very low levels of MyHC I.9 We also did not examine the expression of MyHC IIL in the CT muscle since its baseline expression of this isoform is very low.10

Extraction of RNA from the muscles and SYBR Green real time-RT-PCR

Spec (examine) Regulation (effect) of Gene_expression (expression) of MyHC I in muscles
7) Confidence 0.43 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0.08 Pain Relevance 0.06
Determining the effect of different radiation doses on the MyHC isoform expressions
Spec (Determining) Regulation (effect) of Gene_expression (expressions) of MyHC isoform
8) Confidence 0.43 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0.27 Pain Relevance 0.10
We investigated the effect of irradiation on the myosin heavy chain (MyHC) expression in laryngeal muscles.


Spec (investigated) Regulation (effect) of Gene_expression (expression) of MyHC in muscles
9) Confidence 0.26 Published 2011 Journal Yonsei Medical Journal Section Abstract Doc Link PMC3017692 Disease Relevance 0.39 Pain Relevance 0.05
Effect of 20 Gy irradiation on the laryngeal muscles' MyHC isoform expressions over time
Regulation (Effect) of Gene_expression (expressions) of MyHC isoform in muscles
10) Confidence 0.23 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0.06 Pain Relevance 0
Effect of different radiation doses on the laryngeal muscles' MyHC isoform expressions
Regulation (Effect) of Gene_expression (expressions) of MyHC isoform in muscles
11) Confidence 0.23 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0.17 Pain Relevance 0
Five rats of each group were also sacrificed by a barbiturate overdose to examine the effects of radiation on the body weight loss and the laryngeal muscles' MyHC isoform expression.


Spec (examine) Regulation (effects) of Gene_expression (expression) of MyHC isoform in muscles associated with body weight and overdose
12) Confidence 0.23 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017692 Disease Relevance 0.29 Pain Relevance 0.05

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