INT82760

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.18
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
DRG 4
brain 2
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 5 99.82 Very High Very High Very High
sodium channel 5 99.76 Very High Very High Very High
withdrawal 1 95.52 Very High Very High Very High
Pain 19 95.12 Very High Very High Very High
tetrodotoxin 2 92.16 High High
antagonist 5 91.60 High High
ischemia 7 88.64 High High
Hippocampus 26 85.64 High High
Dorsal horn 11 84.88 Quite High
MU agonist 1 84.32 Quite High
Disease Link Frequency Relevance Heat
Stress 20 100.00 Very High Very High Very High
Adhesions 3 97.40 Very High Very High Very High
Injury 20 93.68 High High
Adult Respiratory Distress Syndrome 43 92.88 High High
Pancreatitis 2 91.16 High High
Hemorrhagic Shock 3 90.04 High High
Cv Unclassified Under Development 7 88.64 High High
Lung Injury 22 79.68 Quite High
Depression 6 79.16 Quite High
Pain 27 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Splanchnic nerve resection, but not vagotomy, affected the visceromotor response, and attenuated the ERK1/2 activation in DRG neurons produced by GD.
Negative_regulation (attenuated) of Positive_regulation (activation) of ERK1 in DRG
1) Confidence 0.57 Published 2008 Journal Gastroenterology Section Body Doc Link 18395090 Disease Relevance 0.12 Pain Relevance 0
The agonist-induced activation of ERK1/2 was completely abolished by preincubation of the cells with the endocytosis inhibitors phenylarsine oxide and monodansylcadaverine as well as overexpression of a dominant-negative mutant of dynamin 1 (DynK44A), indicating that receptor internalization was required for ERK1/2 activation.
Negative_regulation (abolished) of Positive_regulation (activation) of ERK1 associated with agonist
2) Confidence 0.42 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.25
Transfection of Chinese hamster ovary cells with a rat brain type IIa voltage-gated sodium channel completely inhibited shear stress-mediated ERK1/2 activation in these cells.
Negative_regulation (inhibited) of Positive_regulation (activation) of ERK1 in brain associated with stress and sodium channel
3) Confidence 0.41 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.62 Pain Relevance 0.48
Intrathecal injection of TRPA1 antisense attenuated the visceromotor response, and suppressed ERK1/2 activation in the DRG, but not NG, neurons produced by GD.
Negative_regulation (suppressed) of Positive_regulation (activation) of ERK1 in DRG
4) Confidence 0.41 Published 2009 Journal Gut Section Body Doc Link 19515638 Disease Relevance 0.07 Pain Relevance 0
We addressed initial p-ERK activation by assessing protein levels at 10 min after 50 ?
Negative_regulation (addressed) of Positive_regulation (activation) of p-ERK
5) Confidence 0.25 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.32 Pain Relevance 0.49
The DADLE-dependent increases in Akt and ERK1/2 phosphorylation were abolished by either MPI or AG1478, confirming a signaling through the EGFR pathway.
Negative_regulation (abolished) of Positive_regulation (increases) of ERK1
6) Confidence 0.24 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.27 Pain Relevance 0.41
and IL- l production [1], and reduced activation of MAP kinase p38 and ERK-1 [6].
Negative_regulation (reduced) of Positive_regulation (activation) of ERK-1
7) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.72 Pain Relevance 0.15

General Comments

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