INT82762

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 7.72
Pain Relevance 7.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
PSCs 4
exocrine pancreas 2
neurons 2
brain 2
CHO 2
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 17 99.76 Very High Very High Very High
agonist 24 99.74 Very High Very High Very High
Dopamine 24 99.40 Very High Very High Very High
sodium channel 30 99.12 Very High Very High Very High
Neurotransmitter 2 99.04 Very High Very High Very High
Intracerebroventricular 3 98.74 Very High Very High Very High
antagonist 13 98.52 Very High Very High Very High
tetrodotoxin 13 98.04 Very High Very High Very High
dorsal root ganglion 10 98.04 Very High Very High Very High
Pain 143 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 76 100.00 Very High Very High Very High
Nociception 57 99.98 Very High Very High Very High
Targeted Disruption 3 99.40 Very High Very High Very High
Ganglion Cysts 10 98.04 Very High Very High Very High
Pain 194 97.36 Very High Very High Very High
Cancer 2 97.04 Very High Very High Very High
Necrosis 1 96.80 Very High Very High Very High
Eating Disorder 3 89.80 High High
Reprotox - General 3 2 88.12 High High
Endometriosis (extended) 1 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP causes the activation of p38 or ERK1/2, mitogen activated protein kinases (MAPKs) resulting in the release of tumor necrosis factor-alpha (TNF) and Interleukin-6 (IL-6) from microglia.
Positive_regulation (causes) of Positive_regulation (activation) of ERK1 in microglia associated with necrosis and cancer
1) Confidence 0.67 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 0.42 Pain Relevance 0.07
Additionally, s.c. injection of either saline or bee venom significantly augmented the activation of ERK1 and ERK2 (Fig. 3A, Tables 1 and 2).
Positive_regulation (augmented) of Positive_regulation (activation) of ERK1
2) Confidence 0.62 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.33 Pain Relevance 0.39
To determine whether mechanosensitive ion channels participate in the EC response to shear stress, we characterized the role of ion transport in shear stress-mediated extracellular signal-regulated kinase (ERK1/2) stimulation.
Positive_regulation (stress-mediated) of Positive_regulation (stimulation) of ERK1 associated with stress
3) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.60 Pain Relevance 0.18
Overexpression of ErbB2 in the exocrine pancreas resulted in increased RAS activity and downstream activation of ERK1/2, but not in transgenic increased proliferation of acinar and ductal cells.
Neg (not) Positive_regulation (increased) of Neg (not) Positive_regulation (activation) of ERK1 in exocrine pancreas associated with targeted disruption
4) Confidence 0.49 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.55 Pain Relevance 0.21
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (increased) of Positive_regulation (activation) of ERK 1 associated with dopamine, agonist and intracerebroventricular
5) Confidence 0.49 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.70
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (produces) of Positive_regulation (activation) of ERK 1 associated with dopamine, agonist and intracerebroventricular
6) Confidence 0.49 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.70
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (enhanced) of Positive_regulation (activation) of ERK 1 associated with dopamine, agonist and intracerebroventricular
7) Confidence 0.49 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.70
The agonist-induced activation of ERK1/2 was completely abolished by preincubation of the cells with the endocytosis inhibitors phenylarsine oxide and monodansylcadaverine as well as overexpression of a dominant-negative mutant of dynamin 1 (DynK44A), indicating that receptor internalization was required for ERK1/2 activation.
Positive_regulation (required) of Positive_regulation (activation) of ERK1 associated with agonist
8) Confidence 0.49 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.21
NTS2-induced activation of ERK1/2 was not species-specific, because the same agonistic effects of NT and analogs were observed in CHO cells transfected with the human NTS2 receptor.
Positive_regulation (NTS2-induced) of Positive_regulation (activation) of ERK1 in CHO
9) Confidence 0.49 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.18
The Na+ effect was concentration-dependent (maximal effect, </=12.5 mM) and was specific for shear stress-mediated ERK1/2 activation as epidermal growth factor-stimulated ERK1/2 activation was unaffected by removal of extracellular Na+.
Positive_regulation (stimulated) of Positive_regulation (activation) of ERK1 associated with stress
10) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.67 Pain Relevance 0.35
Shear stress-mediated ERK1/2 activation was potentiated by the voltage-gated sodium channel antagonist, tetrodotoxin (100 nM), to a magnitude similar to that achieved with extracellular Na+ withdrawal.
Positive_regulation (stress-mediated) of Positive_regulation (activation) of ERK1 associated with stress, tetrodotoxin, antagonist, sodium channel and withdrawal
11) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.67 Pain Relevance 0.41
Replacement of all extracellular Na+ with either N-methyl-D-glucamine or choline chloride increased the ERK1/2 stimulation in response to shear stress by 1.89 +/- 0.1-fold.
Positive_regulation (increased) of Positive_regulation (stimulation) of ERK1 associated with stress
12) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.66 Pain Relevance 0.23
The Na+ effect was concentration-dependent (maximal effect, </=12.5 mM) and was specific for shear stress-mediated ERK1/2 activation as epidermal growth factor-stimulated ERK1/2 activation was unaffected by removal of extracellular Na+.
Positive_regulation (stress-mediated) of Positive_regulation (activation) of ERK1 associated with stress
13) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.67 Pain Relevance 0.33
Shear stress-mediated ERK1/2 activation was potentiated by the voltage-gated sodium channel antagonist, tetrodotoxin (100 nM), to a magnitude similar to that achieved with extracellular Na+ withdrawal.
Positive_regulation (potentiated) of Positive_regulation (activation) of ERK1 associated with stress, tetrodotoxin, antagonist, sodium channel and withdrawal
14) Confidence 0.49 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10400628 Disease Relevance 0.66 Pain Relevance 0.42
METHODS: Rat PSCs were incubated with ethanol (50 mM) or acetaldehyde (200 microM) for 15 min, 30 min, 60 min, and 24 h; and activities of ERK 1/2, JNK, and p38 kinase were assessed in cell lysates using kinase assays and Western blot.
Positive_regulation (assessed) of Positive_regulation (activities) of ERK 1 in PSCs
15) Confidence 0.49 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
RESULTS: Ethanol and acetaldehyde increased the activation of all 3 subfamilies (ERK 1/2, JNK and p38 kinase) of the MAPK pathway in PSCs.
Positive_regulation (increased) of Positive_regulation (activation) of ERK 1 in PSCs
16) Confidence 0.49 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
Opiate drugs (and specifically the delta-agonists) could promote survival signals in the brain through inhibition of FADD, which in turn is dependent on the activation of the antiapoptotic ERK1/2 signaling pathway.
Positive_regulation (dependent) of Positive_regulation (activation) of ERK1 in brain associated with agonist and opiate
17) Confidence 0.45 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482086 Disease Relevance 0.07 Pain Relevance 0.74
Gastric distention induced the activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) in DRG and NG neurons 2 min after stimulation, and most of the phosphorylated-ERK1/2-labelled DRG neurons were TRPA1-positive neurons.
Positive_regulation (induced) of Positive_regulation (activation) of ERK1 in neurons
18) Confidence 0.45 Published 2009 Journal Gut Section Body Doc Link 19515638 Disease Relevance 0.08 Pain Relevance 0
Activation of ERK1 began to increase within 30 min of s.c. injection and remained at a relatively high level untill the end of the experimental period.
Positive_regulation (increase) of Positive_regulation (Activation) of ERK1
19) Confidence 0.44 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.21 Pain Relevance 0.39
These effects were not accompanied by changes in the activation state of c-Jun N-terminal kinase (JNK), another member of the MAP kinase superfamily. 4AP-induced ERK1/2 activation was inhibited by the voltage-gated Na(+) channel blocker tetrodotoxin (1 micro m).
Positive_regulation (4AP-induced) of Positive_regulation (activation) of ERK1 associated with tetrodotoxin
20) Confidence 0.40 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086522 Disease Relevance 0.15 Pain Relevance 0.14

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