INT82769

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Context Info
Confidence 0.00
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 23
Disease Relevance 7.78
Pain Relevance 9.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm1) plasma membrane (Grm1) nucleus (Grm1)
signal transducer activity (Grm1)
Anatomy Link Frequency
neurons 3
spinal cord 2
pyramidal neurons 2
molecular layer 1
retina 1
Grm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 190 100.00 Very High Very High Very High
depression 181 100.00 Very High Very High Very High
Pyramidal cell 102 99.88 Very High Very High Very High
Calcium channel 56 99.84 Very High Very High Very High
Dorsal horn neuron 22 99.84 Very High Very High Very High
Inflammation 28 99.76 Very High Very High Very High
Hyperalgesia 5 99.76 Very High Very High Very High
Thalamus 55 99.22 Very High Very High Very High
Pain 25 99.16 Very High Very High Very High
Spinal cord 23 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 181 100.00 Very High Very High Very High
Nociception 37 100.00 Very High Very High Very High
INFLAMMATION 17 99.76 Very High Very High Very High
Hyperalgesia 6 99.76 Very High Very High Very High
Pain 18 99.16 Very High Very High Very High
Targeted Disruption 121 93.44 High High
Adhesions 3 92.24 High High
Inflammatory Pain 11 90.20 High High
Injury 1 87.36 High High
Hypersensitivity 1 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This potentiation is not associated with increased mGlu1 or mGlu5 receptor expression but is associated with increased levels of phosphorylated ERK in dorsal horn neurons.
Positive_regulation (increased) of mGlu1 in neurons associated with dorsal horn neuron
1) Confidence 0.00 Published 2004 Journal Pain Section Abstract Doc Link 15327816 Disease Relevance 0.56 Pain Relevance 0.56
We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord.
Positive_regulation (activation) of mGluR1 in spinal cord associated with spinal cord
2) Confidence 0.67 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.71
Most previous studies have focused on the group I metabotropic glutamate receptors (mGluR1 and mGluR5) and activation of phospholipase C signaling by these receptors in modulating nociception.
Positive_regulation (activation) of mGluR1 associated with nociception and glutamate receptor
3) Confidence 0.67 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.41 Pain Relevance 0.47
These results show that mGluR1 and mGluR5 are activated in dorsal horn neurons in response to peripheral inflammation and that activation of these group I mGluRs leads to activation of ERK1 and ERK2, resulting in enhanced pain sensitivity.
Positive_regulation (activated) of mGluR1 in neurons associated with pain, inflammation and dorsal horn neuron
4) Confidence 0.67 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.74 Pain Relevance 0.72
The effect of group I metabotropic glutamate receptor (mGluR1 and mGluR5) activation on identified melanin-concentrating hormone (MCH) neurons was studied using patch-clamp recording in hypothalamic slices from green fluorescent protein-expressing transgenic mice.
Positive_regulation (activation) of mGluR1 in neurons associated with targeted disruption and glutamate receptor
5) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17959799 Disease Relevance 0.09 Pain Relevance 0.20
In contrast, small prefrontal boutons formed synapses mainly with PV+ thalamic projection neurons with metabotropic glutamate receptors, mGluR1a (Fig. 11, m1).
Positive_regulation (metabotropic) of mGluR1 in prefrontal associated with glutamate receptor and pyramidal cell
6) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1952177 Disease Relevance 0 Pain Relevance 0.30
We also show for the first time that i.t. injection of pSM2 (pShag Magic version 2)-grin2b (coding for an short-hairpin RNA to the NR2B subunit of the NMDAR) resulted in a dose-dependent decrease in the NR2B protein and blockade of hyperalgesia induced by activation of the mGluR1/5 in (S)-3,5-DHPG-treated mice.
Positive_regulation (activation) of mGluR1 associated with hyperalgesia
7) Confidence 0.49 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17405869 Disease Relevance 0.33 Pain Relevance 0.66
Therefore, the residual Ca2+ response to group-1 mGluR activation in PLC-?
Positive_regulation (activation) of mGluR
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770323 Disease Relevance 0 Pain Relevance 0.05
Furthermore, we find that inflammation-evoked ERK activation, which is required for nociceptive plasticity, is downstream of mGluR1 and mGluR5.
Positive_regulation (activation) of mGluR1 associated with nociception and inflammation
9) Confidence 0.20 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.59 Pain Relevance 0.73
Finally, Vim mRNA is expressed at a roughly similar level, while significantly fewer cFos, Slc1a3, and Grm1 transcripts are expressed in the WT mouse retina.
Positive_regulation (fewer) of Grm1 in retina
10) Confidence 0.18 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.07 Pain Relevance 0
Furthermore, activation of mGluR1 at the VPL enhanced pain behavior in the second phase in the wild-type mice.
Positive_regulation (activation) of mGluR1 in VPL associated with pain
11) Confidence 0.09 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 1.31 Pain Relevance 0.89
The mouse thalamus also has been shown to express a high level of metabotropic glutamate receptor type 1 (mGluR1), which stimulates PLCbetas through activation of Galphaq/11 protein.
Positive_regulation (level) of mGluR1 in thalamus associated with glutamate receptor and thalamus
12) Confidence 0.06 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 0.66 Pain Relevance 0.46
Ca2+ influx through voltage-gated Ca2+ channels, mGluR1 activation and AMPA receptor activation are required to induce LTD [36], [37].
Positive_regulation (activation) of mGluR1 associated with depression
13) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.78 Pain Relevance 0.39
The metabotropic glutamate receptor type 1 (mGluR1)-mediated slow synaptic response was induced by repetitive stimulation of PFs (50 Hz, 1–20 times) in the molecular layer in the presence of 10 µM ?
Positive_regulation (induced) of mGluR1 in molecular layer associated with glutamate receptor
14) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0 Pain Relevance 0.22
Recently, we reported that mGluR1 activity supports RP induction by facilitating the PKA/phospho-DARPP-32/PP-1 inhibition pathway (Sugiyama et al, 2008).
Positive_regulation (induction) of mGluR1
15) Confidence 0.04 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.15 Pain Relevance 0.12
2, mGluR1, AMPA receptors and Ca2+ are key mediators of LTD induction [36], [37].
Positive_regulation (induction) of mGluR1 associated with depression
16) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.87 Pain Relevance 0.49
These data suggest that the mGluR1 subtype is activated endogenously during brief high-intensity cutaneous stimuli (PRESS, PINCH) and is critically involved in capsaicin-induced central sensitization.
Positive_regulation (activated) of mGluR1 associated with central sensitization and qutenza
17) Confidence 0.03 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10400956 Disease Relevance 0.07 Pain Relevance 0.87
The results shown here suggest that the activation of both mGluR1 and mGluR5 along with NK1 receptors, may be involved in the generation of the slow EPSC in the spinal cord DH.
Positive_regulation (activation) of mGluR1 in spinal cord associated with dorsal horn and spinal cord
18) Confidence 0.03 Published 2008 Journal Neuroscience Section Abstract Doc Link 18554818 Disease Relevance 0 Pain Relevance 0.94
Our finding that both mGluR5 and mGluR1 activation are required for the full effect of DHPG is consistent with previous work demonstrating the effects of both receptor subtypes in CA1 pyramidal neurons [26],[41],[44], despite greater expression of the mGluR5 subunit [50]–[55].
Positive_regulation (activation) of mGluR1 in pyramidal neurons associated with pyramidal cell
19) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.05
One possible mechanism is a current similar to the inward current mediated by mGluR1 activation previously described in CA3 pyramidal neurons, which was not dependent on G-protein activation (like the slow ADP reported here) but required activation of a Src-family tyrosine kinase [39].
Positive_regulation (activation) of mGluR1 in pyramidal neurons associated with pyramidal cell
20) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.09

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