INT82795

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 6.10
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
HL-60 1
platelet 1
epithelial cells 1
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 6 99.96 Very High Very High Very High
opioid receptor 6 87.92 High High
Angina 1 73.84 Quite High
cytokine 6 73.60 Quite High
Restless leg syndrome 1 70.04 Quite High
dexamethasone 22 69.24 Quite High
chemokine 99 50.00 Quite Low
addiction 5 50.00 Quite Low
agonist 9 47.92 Quite Low
cINOD 13 42.84 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 72 100.00 Very High Very High Very High
Ovarian Cancer 86 99.76 Very High Very High Very High
Primary Effusion Lymphoma 4 99.74 Very High Very High Very High
Cancer 254 93.48 High High
Alagille Syndrome 3 92.60 High High
Chromosome Aberrations 2 90.08 High High
Colorectal Cancer 2 87.20 High High
Disease 83 85.68 High High
Colon Cancer 65 84.56 Quite High
Congenital Anomalies 2 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present case demonstrated a rare category of PEL that is not associated with HHV-8 or C-MYC gene rearrangement.
C-MYC Binding (associated) of associated with primary effusion lymphoma
1) Confidence 0.47 Published 2005 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 15588855 Disease Relevance 1.09 Pain Relevance 0.07
bound to the P2 c-myc promoter.
c-myc Binding (bound) of
2) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.09 Pain Relevance 0
It can be concluded that wild-type p53 and/or up-regulation of c-myc is associated with indomethacin-mediated differential apoptosis in gastric epithelial cells.
c-myc Binding (associated) of in epithelial cells associated with apoptosis
3) Confidence 0.36 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.78 Pain Relevance 0
Pharmacological studies using specific ligands demonstrated a typical opioid profile for the HuMOR-c-myc-his-tag construct, whereas the GFP-HuMOR-c-myc-his-tag receptor was unable to bind opioid drugs.
c-myc Neg (unable) Binding (bind) of associated with opioid
4) Confidence 0.36 Published 2005 Journal Protein Expr. Purif. Section Abstract Doc Link 16095919 Disease Relevance 0 Pain Relevance 0.32
Pharmacological studies using specific ligands demonstrated a typical opioid profile for the HuMOR-c-myc-his-tag construct, whereas the GFP-HuMOR-c-myc-his-tag receptor was unable to bind opioid drugs.
c-myc Neg (unable) Binding (bind) of associated with opioid
5) Confidence 0.36 Published 2005 Journal Protein Expr. Purif. Section Abstract Doc Link 16095919 Disease Relevance 0 Pain Relevance 0.32
Accordingly, several transcription factors associated with cell cycle control were affected by cilostazol, particularly c-myc. c-Myc DNA binding as well as its transcriptional activity was severely impaired in cilostazol-treated cells.
c-Myc Binding (binding) of
6) Confidence 0.36 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19545562 Disease Relevance 0.32 Pain Relevance 0.07
B, the interaction of the pro-apoptotic factor NOXA and the c-myc oncogene, and finally, the transcription factor x-box binding protein 1 (XBP-1) and the unfolded protein response.
c-myc Binding (interaction) of associated with apoptosis
7) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.19 Pain Relevance 0.10
The interaction of NOXA and c-myc also provides a possible rationale for the encouraging clinical data noted thus far when histone deacetylase (HDAC) inhibitors are combined with bortezomib.
c-myc Binding (interaction) of
8) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.63 Pain Relevance 0
Third, they showed that the rs6983267 region physically interacts with the MYC promoter region.
MYC Binding (interacts) of
9) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3017062 Disease Relevance 0.51 Pain Relevance 0
Members of the Myc family and the Mad family with expression data available were: c-Myc, Myc binding protein 2 (a nuclear protein that binds specifically to Myc) [26] and Mad2.
Myc Binding (binds) of
10) Confidence 0.16 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.24 Pain Relevance 0
Myc, specifically c-myc is abundant in proliferating HL-60 cells, but its downregulation is associated with differentiating HL-60 cells.
Myc Binding (associated) of in HL-60
11) Confidence 0.16 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.15 Pain Relevance 0
Members of the Myc family and the Mad family with expression data available were: c-Myc, Myc binding protein 2 (a nuclear protein that binds specifically to Myc) [26] and Mad2.
Myc Binding (binding) of
12) Confidence 0.16 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.23 Pain Relevance 0
Members of the Myc family and the Mad family with expression data available were: c-Myc, Myc binding protein 2 (a nuclear protein that binds specifically to Myc) [26] and Mad2.
Myc Binding (binding) of
13) Confidence 0.16 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.23 Pain Relevance 0
Thus there are minimal effects on circulating platelet levels. cMYC binds to and induces expression of (no. 6) p73, and both together downregulate PDGF beta receptors [63].
cMYC Binding (binds) of in platelet
14) Confidence 0.09 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.27 Pain Relevance 0
, FGF1, MYC, EGFR, KRAS, HER2, and AKT2, have been also associated with ovarian cancer [56].
MYC Binding (associated) of associated with ovarian cancer
15) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.11 Pain Relevance 0
No association was seen for ErbB4, PTEN or c-MYC.
c-MYC Neg (No) Binding (association) of
16) Confidence 0.03 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.27 Pain Relevance 0

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