INT82796

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 9.83
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 99.84 Very High Very High Very High
cocaine 292 99.82 Very High Very High Very High
qutenza 130 99.80 Very High Very High Very High
narcan 28 99.52 Very High Very High Very High
antagonist 26 98.34 Very High Very High Very High
Opioid 40 98.12 Very High Very High Very High
Inflammation 23 97.90 Very High Very High Very High
agonist 14 97.84 Very High Very High Very High
addiction 1 83.40 Quite High
opioid receptor 26 75.00 Quite High
Disease Link Frequency Relevance Heat
Lipoma 1 99.60 Very High Very High Very High
Cancer 190 98.44 Very High Very High Very High
Stress 38 98.42 Very High Very High Very High
Liposarcoma 13 98.16 Very High Very High Very High
Pancreatic Cancer 105 98.12 Very High Very High Very High
INFLAMMATION 34 97.90 Very High Very High Very High
Cystic Kidney Diseases 6 97.20 Very High Very High Very High
Apoptosis 311 96.92 Very High Very High Very High
Alagille Syndrome 6 96.08 Very High Very High Very High
Retinoblastoma 81 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of OGF on p21 were found to be receptor mediated, as concomitant exposure to the opioid antagonist naloxone blocked the up-regulation of p21 by OGF; naloxone treatment alone had no effect on p21 levels, indicating that there was not simply a counterbalance of up- and down-regulation between OGF and naloxone.
Neg (no) Regulation (effect) of p21 associated with antagonist, narcan and opioid
1) Confidence 0.53 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.58 Pain Relevance 0.39
Estrogen has been shown to upregulate p21 in vitro[29], and may have contributed to the higher p21 levels in the cystic female rats in the present study.
Regulation (upregulate) of p21
2) Confidence 0.44 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.54 Pain Relevance 0
Curcumin mediated NrF2 pathway significantly altered p21(Waf1/Cip1) levels.
Regulation (altered) of Waf1
3) Confidence 0.44 Published 2006 Journal Curr Cancer Drug Targets Section Abstract Doc Link 17168675 Disease Relevance 0.21 Pain Relevance 0
p21 has been considered as a target for potential anticancer drugs [19,20].
Regulation (target) of p21
4) Confidence 0.39 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.81 Pain Relevance 0
The primers used were: for the human p21Cip1 promoter containing the VDRE (located at ?
Regulation (were) of p21Cip1
5) Confidence 0.37 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
On immunohistochemistry, lipoma-like cells stained positive for S100, vimentin and calretinin but not for p53, p21 WaF1, and c-kit, indicating a well-differentiated liposarcoma.
Neg (not) Regulation (positive) of WaF1 associated with liposarcoma and lipoma
6) Confidence 0.27 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1866233 Disease Relevance 0.66 Pain Relevance 0
There was no change in the p21waf1/cip1 and c-myc protein levels in the MKN28 cells.
Neg (no) Regulation (change) of cip1
7) Confidence 0.26 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.87 Pain Relevance 0.11
Cellular over expression of heme oxygenase-1 (HO-1), the anti-inflammatory and anti-oxidative stress protein that catalyzes heme degradation producing biliverdin, iron and CO, up-regulates p21cip1/waf1, diminishes cell growth proliferation and confers marked resistance to apoptosis.
Regulation (regulates) of p21cip1 associated with stress, inflammation and apoptosis
8) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.75 Pain Relevance 0.10
We were particularly interested in the regulation of dual-purpose proteins like cyclin-A, p21/waf-1 and PCNA that not only regulate progression through cell cycle, but also participate in DNA repair and blockage of apoptosis.
Regulation (regulation) of waf-1 associated with apoptosis
9) Confidence 0.26 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.31 Pain Relevance 0
We were particularly interested in the regulation of dual-purpose proteins like cyclin-A, p21/waf-1 and PCNA that not only regulate progression through cell cycle, but also participate in DNA repair and blockage of apoptosis.
Regulation (regulation) of p21 associated with apoptosis
10) Confidence 0.26 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.31 Pain Relevance 0
Finally, confirmation that p21 was indeed the target of OGF was validated in siRNA studies whereby pancreatic cancer cells exposed to p21 siRNA exhibited no change in growth after exposure to OGF.
Regulation (target) of p21 associated with pancreatic cancer
11) Confidence 0.23 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.61 Pain Relevance 0.36
Cyclins and the cyclin-dependent kinase inhibitors p21 and p27 are also regulated by proteasome-dependent proteolysis [4].
Regulation (regulated) of p21
12) Confidence 0.20 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234426 Disease Relevance 0.48 Pain Relevance 0.03
Sulindac sulfide induced expression of p21wafl/cipl in a dose-dependent fashion, decreased cyclin D1 protein levels, and increased Rb hypophosphorylation. p21waf1/cip1 protein levels increased without a significant increase in wild-type p53, suggesting that sulindac sulfide induces a p53-independent pathway regulating p2lwafl/ciP1 protein levels in SCCHN.
Regulation (regulating) of ciP1
13) Confidence 0.19 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 17172818 Disease Relevance 0.36 Pain Relevance 0.07
Curcumin mediated NrF2 pathway significantly altered p21(Waf1/Cip1) levels.
Regulation (altered) of Cip1
14) Confidence 0.19 Published 2006 Journal Curr Cancer Drug Targets Section Abstract Doc Link 17168675 Disease Relevance 0.21 Pain Relevance 0
The mRNA and protein levels of p53, p21waf1/cip1, and c-myc were determined by Northern and Western blotting.
Spec (determined) Regulation (determined) of cip1
15) Confidence 0.12 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.97 Pain Relevance 0.15
Other mechanisms of the anti-proliferative activity of capsaicin included regulation of cyclin/cdks, p21 and p53 in the aforementioned cells.
Regulation (regulation) of p21 associated with qutenza
16) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.44 Pain Relevance 0.69
Interestingly, in NCI cell line the effect on p21 was more evident when a combination of CDDP and piroxicam was used.
Regulation (effect) of p21
17) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2412853 Disease Relevance 0.45 Pain Relevance 0
In our experimental model, when we looked at the molecular regulators of cell cycle, we detected in MSTO and NCI a significant down-regulation of Cyc D1 and in NCI an up-regulation of p21 expression level.
Regulation (regulation) of p21
18) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2412853 Disease Relevance 0.45 Pain Relevance 0
In both cell lines, we did not detect an upregulation of P21Cip1 protein in spite of cell-cycle arrests.


Regulation (upregulation) of P21Cip1
19) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.35 Pain Relevance 0.04
Interestingly, in Ist-Mes-1 and MPP89 no differences in p21 and p27 were observed, when compared to control (Figure 5).
Neg (no) Regulation (differences) of p21
20) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2828989 Disease Relevance 0.13 Pain Relevance 0

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