INT82797

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 8.01
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 26 73.96 Quite High
COX-2 inhibitor 52 51.36 Quite High
Spinal cord 6 50.20 Quite High
antagonist 23 44.52 Quite Low
Central nervous system 19 33.20 Quite Low
Nicotine 15 24.60 Low Low
Inflammation 53 5.00 Very Low Very Low Very Low
agonist 36 5.00 Very Low Very Low Very Low
cytokine 26 5.00 Very Low Very Low Very Low
chemokine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Non-small-cell Lung Cancer 107 100.00 Very High Very High Very High
Cancer 442 99.44 Very High Very High Very High
Lung Cancer 163 98.16 Very High Very High Very High
Apoptosis 295 97.80 Very High Very High Very High
Retinoblastoma 2 96.96 Very High Very High Very High
Alagille Syndrome 6 95.00 High High
Death 58 88.80 High High
Advanced Or Metastatic Breast Cancer 17 86.64 High High
Stomach Cancer 7 81.96 Quite High
Toxicity 20 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ID2 can also promote proliferation by inhibiting the E-box mediated transcription of cell cycle inhibitors (for example, p21CIP1/WAF1, p15INK4B, and p16INK4B) (Pagliuca et al. 2000).
Transcription (transcription) of p21CIP1/WAF1
1) Confidence 0.69 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.11 Pain Relevance 0.03
Furthermore, in basal conditions, these mutants are as active as the wild-type protein in repressing DRE-dependent transcription and remain bound to DNA acting as dominant negative repressors following Ca2+ or cAMP stimulation (1,3,7).
Transcription (transcription) of wild-type protein
2) Confidence 0.57 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.11 Pain Relevance 0
In MKN28 cells, the levels of p53, p21waf1/cip1, and c-myc mRNA remained unchanged over the 24-hr treatment with indomethacin, but the p53 protein level was elevated after 4 hr.
Transcription (levels) of cip1
3) Confidence 0.29 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.93 Pain Relevance 0.12
The mRNA and protein levels of p53, p21waf1/cip1, and c-myc were determined by Northern and Western blotting.
Spec (determined) Transcription (levels) of cip1
4) Confidence 0.29 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.97 Pain Relevance 0.15
Eight patients (73%) had a p53 mutation; serial biopsies showed increases in p53 mRNA and p21 (WAF1/Cip1 mRNA).
Transcription (mRNA) of p21
5) Confidence 0.25 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.48 Pain Relevance 0
Although a modest but significant increment on p15 and p21 mRNA expression was detected, this was not associated with clinical response.
Transcription (expression) of p21
6) Confidence 0.18 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.31 Pain Relevance 0
For example, after DNA damage, p53, a tumor suppressor gene, activates transcription of p21, which inhibits cyclin E phosphorylation leading to hypophosphorylation of retinoblastoma protein (pRb) [81].
Transcription (transcription) of p21 associated with cancer and retinoblastoma
7) Confidence 0.13 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.28 Pain Relevance 0.03
of p21 mRNA and protein expression in NSCLC, and this coincided with a
Transcription (expression) of p21 associated with non-small-cell lung cancer
8) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.96 Pain Relevance 0
Of note, p21 antisense oligonucleotides
Transcription (oligonucleotides) of p21
9) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.99 Pain Relevance 0
of p21 mRNA and protein expression in NSCLC, and this coincided with a
Transcription (coincided) of p21 associated with non-small-cell lung cancer
10) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.97 Pain Relevance 0
the expression of p21 mRNA and protein expression in NSCLC, and this coincided
Transcription (expression) of p21 associated with non-small-cell lung cancer
11) Confidence 0.06 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.93 Pain Relevance 0
the expression of p21 mRNA and protein expression in NSCLC, and this coincided
Transcription (expression) of p21 associated with non-small-cell lung cancer
12) Confidence 0.06 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.98 Pain Relevance 0

General Comments

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