INT82808

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 5.19
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA4) plasma membrane (ITGA4)
Anatomy Link Frequency
joint 1
leukocytes 1
melanocyte 1
mononuclear cells 1
ITGA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 96.16 Very High Very High Very High
antagonist 6 90.16 High High
chemokine 10 79.64 Quite High
Angina 1 78.48 Quite High
Inflammatory marker 2 75.00 Quite High
melanocortin 1 receptor 2 75.00 Quite High
cINOD 2 67.96 Quite High
rheumatoid arthritis 36 67.92 Quite High
Potency 4 61.04 Quite High
Inflammatory response 2 27.04 Quite Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 300 99.86 Very High Very High Very High
Adhesions 19 99.36 Very High Very High Very High
Rheumatoid Arthritis 77 98.32 Very High Very High Very High
INFLAMMATION 30 96.16 Very High Very High Very High
Toxicity 20 93.64 High High
Myocardial Infarction 6 93.08 High High
Asthma 6 88.72 High High
Contact Dermatitis 28 85.08 High High
Cv General 3 Under Development 1 78.48 Quite High
Hypersensitivity 17 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two series have been developed, one that has high selectivity for the activated over the non-activated state of the receptor, and the other which is non-selective inhibiting both activated and non-activated VLA-4.
Positive_regulation (non-activated) of VLA-4
1) Confidence 0.44 Published 2004 Journal Curr Top Med Chem Section Abstract Doc Link 15544540 Disease Relevance 0.58 Pain Relevance 0.17
At positive antigen stimulated sites there was an early expression of CS-1 fibronectin (2 hours), followed by CCL17 and a later accumulation of alplha4/beta1+ (CD49d), CD3+, CD68+, CXCR3+ and CCR5+ mononuclear cells.
Positive_regulation (accumulation) of CD49d in mononuclear cells
2) Confidence 0.14 Published 2002 Journal BMC Dermatol Section Abstract Doc Link PMC122084 Disease Relevance 0.52 Pain Relevance 0.12
After 24 hr of treatment the best results were obtained for cell line FDA; we observed about a 5-fold increase in the amount of wild-type IKAP mRNA after treatment with 5, 10 or 100 µg/ml PS compared to levels in FDA cells treated with the solvent only (Figure 2B).
Positive_regulation (increase) of wild-type
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.43 Pain Relevance 0
At 200 µg/ml PS, the increase was 1.5 fold, and at 300 µg/ml a 1.2-fold increase in wild-type IKAP mRNA levels was observed.
Positive_regulation (increase) of wild-type
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.35 Pain Relevance 0
A significant increase in wild-type IKAP mRNA levels and a shift towards a higher level of exon 20 inclusion was observed with an optimal concentration of 100 µM of kinetin (Figure 7A), with no toxicity observed.
Positive_regulation (increase) of wild-type associated with toxicity
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.69 Pain Relevance 0.03
PS treatment of FD cells elevated wild-type IKAP mRNA and protein levels and resulted in a cell cycle distribution similar to that of the control cells.
Positive_regulation (elevated) of wild-type associated with familial dysautonomia
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.75 Pain Relevance 0
Expression of the Val60Leu, Arg142His, Arg151Cys, Arg160Trp, and Asp294His receptors in COS 1 cells revealed that these receptors were unable to stimulate cAMP production as strongly as the wild type receptor in response to alpha-melanocyte-stimulating hormone stimulation.
Neg (unable) Positive_regulation (stimulate) of wild type receptor in melanocyte
7) Confidence 0.02 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10403794 Disease Relevance 0 Pain Relevance 0.15
As shown in Fig. 4D, LLnL treatment causes the increase of wild-type EPOR while scarce change of mutated EPOR level was observed.
Positive_regulation (increase) of wild-type
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0
We measured the number of leukocytes and enzymes and the expression levels of CD11a, CD18, very-late-after-activation antigen-4 alpha, intracellular adhesion molecule-1 (ICAM-1) and L-selectin by flow cytometry before and after coronary intervention, and at 6, 12, 18, 48 and 72 hours of MI in 5 patients (AMI group).
Positive_regulation (very-late-after-activation) of antigen-4 alpha in leukocytes associated with myocardial infarction and adhesions
9) Confidence 0.01 Published 2004 Journal J. Atheroscler. Thromb. Section Abstract Doc Link 15067196 Disease Relevance 0.85 Pain Relevance 0.08
Interestingly, the chemotactic activity of soluble VCAM-1 is inhibited in the presence of anti-VCAM-1 and anti-VLA-4 [32], suggesting that VCAM-1 produced by RA-SFs contributes to the development of the synovial inflammation by attracting T cells to the joint.
Positive_regulation (presence) of anti-VLA-4 in joint associated with inflammation and rheumatoid arthritis
10) Confidence 0.00 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 1.03 Pain Relevance 0.17

General Comments

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