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Context Info
Confidence 0.56
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 88.48 High High
Eae 12 83.88 Quite High
Opioid 1 78.24 Quite High
anesthesia 2 72.32 Quite High
Hippocampus 8 71.92 Quite High
cerebral cortex 4 70.72 Quite High
long-term potentiation 2 66.80 Quite High
Inflammation 6 64.12 Quite High
rheumatoid arthritis 1 50.36 Quite High
Inflammatory stimuli 1 43.04 Quite Low
Disease Link Frequency Relevance Heat
Frailty 1 97.88 Very High Very High Very High
Obesity 19 95.84 Very High Very High Very High
Targeted Disruption 46 92.32 High High
Toxicity 10 89.48 High High
Alzheimer's Dementia 12 89.12 High High
Stress 8 83.92 Quite High
Hematological Disease 1 83.84 Quite High
Neuroblastoma 2 80.20 Quite High
Anorexia 10 77.40 Quite High
Mycobacterial Infection 41 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leptin deficiency is responsible for immunosuppression and reduced
Negative_regulation (reduced) of Negative_regulation (deficiency) of Leptin
1) Confidence 0.56 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.17 Pain Relevance 0.16
In phase II, high dose fentanyl limited both the cortisol increase and the leptin decrease; thus, the ratio of cortisol increase to leptin decrease was similar for the cardiac patients and the hysterectomy patients.
Negative_regulation (limited) of Negative_regulation (decrease) of leptin
2) Confidence 0.43 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10404818 Disease Relevance 0.40 Pain Relevance 0.15
reducing effect of leptin.
Negative_regulation (reducing) of Negative_regulation (effect) of leptin
3) Confidence 0.07 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.66 Pain Relevance 0.15

General Comments

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