INT82828

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 45
Total Number 51
Disease Relevance 35.12
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COMP) extracellular region (COMP) cell adhesion (COMP)
proteinaceous extracellular matrix (COMP)
Anatomy Link Frequency
cartilage 9
knee 4
tendon 2
ligament 2
masseter 2
COMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 414 99.56 Very High Very High Very High
Osteoarthritis 662 99.50 Very High Very High Very High
psoriasis 133 99.00 Very High Very High Very High
rheumatoid arthritis 117 98.80 Very High Very High Very High
Pain threshold 2 98.68 Very High Very High Very High
imagery 215 98.40 Very High Very High Very High
Inflammation 91 97.44 Very High Very High Very High
depression 4 96.68 Very High Very High Very High
anesthesia 2 89.36 High High
epidural 3 88.92 High High
Disease Link Frequency Relevance Heat
Obesity 489 100.00 Very High Very High Very High
Osteochondrodysplasias 356 100.00 Very High Very High Very High
Cytomegalovirus Infection 52 99.96 Very High Very High Very High
Frailty 15 99.92 Very High Very High Very High
Disease 307 99.70 Very High Very High Very High
Psoriasis 210 99.64 Very High Very High Very High
Seronegative Spondarthritis 288 99.56 Very High Very High Very High
Osteoarthritis 458 99.50 Very High Very High Very High
Knee Osteoarthritis 227 99.48 Very High Very High Very High
Heart Rate Under Development 192 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently Mündermann and co-workers reported that moderate walking activity during 30 minutes in healthy individuals significantly increased serum COMP as measured by the same assay as the one used in our study [26].
Positive_regulation (increased) of COMP
1) Confidence 0.61 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.15 Pain Relevance 0.08
Neidhart and co-workers found increasing serum levels of COMP using another assay in 8 athletes during a marathon run.
Positive_regulation (increasing) of COMP
2) Confidence 0.61 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.09 Pain Relevance 0.04
As can been seen in Fig. 5A, MT-COMP was induced in a dose dependent manner and high levels were attained at 1 and 10 µg/ml of DOX.
Positive_regulation (induced) of MT-COMP
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.20 Pain Relevance 0
The primary accumulation of abnormal COMP also appears to result in the secondary retention of type IX collagen and other proteins, eventually producing large insoluble “inclusion bodies” [Vranka et al., 2001].
Positive_regulation (accumulation) of COMP
4) Confidence 0.58 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.48 Pain Relevance 0
For COMP, a 1-standard deviation increase in COMP increased the odds of subsequent cartilage loss 6.09 times (95% confidence interval [CI] 1.34 to 27.67).
Positive_regulation (increase) of COMP in cartilage
5) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.37 Pain Relevance 0.15
Therefore, this report increases the range of mutations that cause PSACH and EDM1 and provides additional regions to target for mutational analysis.
Positive_regulation (cause) of EDM1 associated with osteochondrodysplasias
6) Confidence 0.50 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 10405447 Disease Relevance 1.05 Pain Relevance 0.15
Therefore, this report increases the range of mutations that cause PSACH and EDM1 and provides additional regions to target for mutational analysis.
Positive_regulation (cause) of PSACH associated with osteochondrodysplasias
7) Confidence 0.50 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 10405447 Disease Relevance 1.05 Pain Relevance 0.15
Serum levels of Cartilage Oligomeric Matrix Protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis

Background

Positive_regulation (increase) of COMP in knee associated with knee osteoarthritis and osteoarthritis
8) Confidence 0.47 Published 2006 Journal BMC Musculoskelet Disord Section Title Doc Link PMC1712338 Disease Relevance 0.36 Pain Relevance 0.18
Only infected cells were considered in this analysis because the shRNA targets the human COMP transcript and does not cross-react with rat COMP.
Positive_regulation (targets) of COMP
9) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.25 Pain Relevance 0
COMP has been shown to be increased in serum at disease onset in RA patients who developed large-joint destruction [50].
Positive_regulation (increased) of COMP in joint associated with rheumatoid arthritis and disease
10) Confidence 0.46 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0.69 Pain Relevance 0.17
In this set of experiments, we used the tetracycline induced MT-COMP adenovirus and varied the dose of doxycycline (DOX) to attain high levels of COMP expression.
Positive_regulation (induced) of MT-COMP
11) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.32 Pain Relevance 0
After 60 minutes of exercise serum COMP levels increased (median increase 1.3 U/L, p < 0.001) at both time points in the exercise group, figure 3.
Positive_regulation (increased) of COMP
12) Confidence 0.41 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0 Pain Relevance 0
In the second study serum COMP was increased immediately after exercise (p = 0.018) and had decreased to baseline levels after 30 minutes.


Positive_regulation (increased) of COMP
13) Confidence 0.41 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712338 Disease Relevance 0.14 Pain Relevance 0.07
The serum COMP levels increased immediately after exercise from a median level of 10.5 U/L to a median level of 11.6 U/L, p = 0.018, figure 4.
Positive_regulation (increased) of COMP
14) Confidence 0.41 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.07 Pain Relevance 0.03
In these endurance-trained runners serum COMP was at baseline elevated compared to healthy age- and sex-matched controls.
Positive_regulation (elevated) of COMP
15) Confidence 0.41 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.08 Pain Relevance 0.04
Serum COMP levels increased during exercise in individuals with knee OA, whereas levels decreased during rest.
Positive_regulation (increased) of COMP in knee associated with osteoarthritis
16) Confidence 0.41 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712338 Disease Relevance 0.15 Pain Relevance 0.07
We did not observe any changes of the baseline COMP levels over the 24-week period, thus there appears to be no long-term influence on the turnover of COMP induced by this physical exercise.
Neg (no) Positive_regulation (induced) of COMP
17) Confidence 0.41 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.08 Pain Relevance 0.04
The increased serum COMP levels were normalized 30 minutes after exercise session, therefore we suggest that samples of blood for analysis of serum COMP should be drawn after at least 30 minutes rest in a seated position.
Positive_regulation (increased) of COMP in blood
18) Confidence 0.41 Published 2006 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1712338 Disease Relevance 0.10 Pain Relevance 0.05
In this study of patients with knee OA, we could in a reproducible fashion show that physical activity according to a predefined protocol resulted in a significant increase in the serum levels of COMP.
Positive_regulation (increase) of COMP in knee associated with osteoarthritis
19) Confidence 0.41 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712338 Disease Relevance 0.10 Pain Relevance 0.05
EMG voluntary activity was recorded from both masseter muscles by means of coaxial needle electrodes before and after the electrical stimulation of MED and/or RAD at intensities below pain threshold.
Positive_regulation (stimulation) of MED in masseter associated with pain threshold
20) Confidence 0.41 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11889506 Disease Relevance 0.34 Pain Relevance 0.14

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