INT82854

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 61
Total Number 72
Disease Relevance 10.14
Pain Relevance 10.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MRGPRX1) signal transducer activity (MRGPRX1)
Anatomy Link Frequency
adrenal medulla 3
smooth muscle 2
neurons 2
dorsal root ganglion 2
AtT20 2
MRGPRX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 12 100.00 Very High Very High Very High
mu opioid receptor 3 100.00 Very High Very High Very High
agonist 1123 99.96 Very High Very High Very High
bradykinin 133 99.64 Very High Very High Very High
dorsal root ganglion 16 99.12 Very High Very High Very High
opioid receptor 320 98.72 Very High Very High Very High
Glutamate 143 98.48 Very High Very High Very High
Glutamate receptor 64 97.60 Very High Very High Very High
analgesia 9 97.10 Very High Very High Very High
Kinase C 243 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 598 99.80 Very High Very High Very High
Adhesions 365 99.28 Very High Very High Very High
Ganglion Cysts 28 98.64 Very High Very High Very High
Disease 190 96.32 Very High Very High Very High
Nociception 11 96.00 Very High Very High Very High
Pain 42 95.96 Very High Very High Very High
Polyhydramnios 3 95.04 Very High Very High Very High
Starvation 21 94.28 High High
Stress 17 93.20 High High
INFLAMMATION 226 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the heterologous system, the SNSR4 selective bovine adrenal medulla peptide BAM22 produces similar amounts of phospholipase C activation as it does in cells expressing only SNSR4.
Gene_expression (expressing) of SNSR4 in adrenal medulla associated with medulla
1) Confidence 0.75 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0.07 Pain Relevance 0.35
The use of some of the other attributes in Signaling can be demonstrated using the experiments by Breit et al. on heterologous systems co-expressing sensory neuron-specific receptors subtype 4 (SNSR-4) and ?
Gene_expression (co-expressing) of sensory neuron-specific receptors subtype 4 in sensory neuron
2) Confidence 0.75 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0.08 Pain Relevance 0.55
The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain.
Gene_expression (located) of MrgX1 in dorsal root ganglion associated with ganglion cysts, pain and dorsal root ganglion
3) Confidence 0.65 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19146417 Disease Relevance 0.19 Pain Relevance 0.23
Linking and complementing existing GPCR resources that provide information about GPCR monomers
Gene_expression (resources) of GPCR
4) Confidence 0.65 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
To circumvent this problem, we expressed human SNSR4 (hSNSR4; also known as Hs.mrgX1) in rat superior cervical ganglion (SCG), dorsal root ganglion (DRG), and hippocampal neurons using nuclear injection or recombinant adenoviruses and examined modulation of ion channels and neurotransmission using whole-cell patch-clamp techniques.
Gene_expression (expressed) of SNSR4 in DRG associated with ganglion cysts and dorsal root ganglion
5) Confidence 0.63 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15163697 Disease Relevance 0.60 Pain Relevance 0.38
In the heterologous system, the SNSR4 selective bovine adrenal medulla peptide BAM22 produces similar amounts of phospholipase C activation as it does in cells expressing only SNSR4.
Gene_expression (selective) of SNSR4 in adrenal medulla associated with medulla
6) Confidence 0.56 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0.07 Pain Relevance 0.43
Linking and complementing existing GPCR resources that provide information about GPCR monomers
Gene_expression (monomers) of GPCR
7) Confidence 0.56 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
In the heterologous system, the SNSR4 selective bovine adrenal medulla peptide BAM22 produces similar amounts of phospholipase C activation as it does in cells expressing only SNSR4.
Gene_expression (produces) of SNSR4 in adrenal medulla associated with medulla
8) Confidence 0.56 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0.07 Pain Relevance 0.43
Providing structural information about physiological GPCR oligomers
Gene_expression (oligomers) of GPCR
9) Confidence 0.56 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.
Gene_expression (expressed) of SNSR4 in neurons
10) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Title Doc Link 15163697 Disease Relevance 0.56 Pain Relevance 0.35
Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.
Gene_expression (expressed) of mrgX1 in neurons
11) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Title Doc Link 15163697 Disease Relevance 0.56 Pain Relevance 0.35
The simulated GPCR set was produced using the PSeq-Gen 1.1 program (Grassly et al. 1997).
Gene_expression (produced) of GPCR
12) Confidence 0.44 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0 Pain Relevance 0
The GPCR tree was produced by a ‘tips down’ approach in which ancestral sequences were constructed for each of the GPCR groups that in turn could be compared directly (Supplementary Data).
Gene_expression (produced) of GPCR
13) Confidence 0.38 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0 Pain Relevance 0
Simulated GPCR set
Gene_expression (set) of GPCR
14) Confidence 0.38 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0 Pain Relevance 0
Ancestor reconstruction and GPCR tree
Gene_expression (tree) of GPCR
15) Confidence 0.38 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0 Pain Relevance 0
In such a situation the ligand at the first GPCR would act as an allosteric agent for the orthosteric agonist of the second GPCR and this would be a heterodimer-specific effect [25] because the ligand would display no direct effect on the second GPCR in assays in which the second GPCR was expressed alone.
Gene_expression (expressed) of GPCR associated with agonist
16) Confidence 0.37 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.22
The basic protocol used to generate Flp-In T-REx HEK-293 cell lines that constitutively express one GPCR and can be induced to express a second has been described previously [32–34].
Gene_expression (express) of GPCR
17) Confidence 0.37 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.06 Pain Relevance 0
This reflects a combination of the traditional view that GPCRs exist and function as non-interacting monomeric species and that ligand screening strategies concentrate on analysis of the function of a single GPCR expressed in isolation.
Gene_expression (expressed) of GPCR
18) Confidence 0.37 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.07 Pain Relevance 0.07
The alpha melanocyte-stimulating hormone receptor (MC1R) is a heptahelical G protein-coupled receptor (GPCR) found in the plasma membrane of melanocytes.
Gene_expression (found) of GPCR in melanocyte
19) Confidence 0.36 Published 2006 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 16914085 Disease Relevance 0 Pain Relevance 0.07
To achieve robust phylogenetic analyses it is necessary to separate out the GPCR groups as relatively small but high quality alignments (Sjölander, 2004).
Gene_expression (groups) of GPCR
20) Confidence 0.33 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0.05 Pain Relevance 0.03

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