INT8286

Context Info Confidence 0.14 First Reported 1992 Last Reported 1997 Negated 1 Speculated 0 Reported most in Title Documents 2 Total Number 2 Disease Relevance 0.05 Pain Relevance 0.42

plasma membrane (Grpr) signal transducer activity (Grpr)

Grpr (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 2 99.96 Potency 1 99.12 Intracerebroventricular 3 82.80 anesthesia 1 80.00 agonist 2 64.44 Opioid 1 52.08

Disease Link Frequency Relevance Heat Adhesions 1 50.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, we show that for the PLC-coupled GRP-R, receptor number had little or no effect on binding affinity, potency for activating PLC, tyrosine phosphorylation of p125FAK, or extent of receptor internalization.

Neg (little) Regulation (effect) of GRP-R associated with potency

1) Confidence 0.14 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.05 Pain Relevance 0.13

Inhibitory effects of the new bombesin receptor antagonist RC-3095 on the luteinizing hormone release in rats.

Regulation (effects) of bombesin receptor associated with antagonist

2) Confidence 0.12 Published 1992 Journal Neuroendocrinology Section Title Doc Link 1369591 Disease Relevance 0 Pain Relevance 0.28

General Comments

This test has worked.