INT82861

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.46
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lalba)
Anatomy Link Frequency
plasma 2
lung 2
Lalba (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 3 98.58 Very High Very High Very High
noradrenaline 8 98.38 Very High Very High Very High
Lasting pain 1 91.12 High High
cva 2 90.88 High High
Glutamate receptor 1 90.72 High High
Kinase C 1 88.96 High High
Spinal cord 2 83.52 Quite High
Dorsal horn 2 82.56 Quite High
Morphine 1 75.76 Quite High
Deep tissue 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 1 100.00 Very High Very High Very High
Hypersensitivity 1 99.32 Very High Very High Very High
Necrosis 2 98.94 Very High Very High Very High
Cv General 2 Under Development 6 98.76 Very High Very High Very High
Cancer 2 98.76 Very High Very High Very High
Hyperalgesia 3 98.58 Very High Very High Very High
Pressure Volume 2 Under Development 2 97.54 Very High Very High Very High
Sepsis 2 92.24 High High
Pain 2 91.12 High High
Cv General 3 Under Development 2 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vgx rats showed sustained hyperalgesia in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma creatine phosphokinase or lactose dehydrogenase levels) accompanied by hypersensitivity to colonic distension.
Positive_regulation (induced) of Gene_expression (levels) of lactose dehydrogenase in plasma associated with hyperalgesia, disorders of creatine metabolism and hypersensitivity
1) Confidence 0.30 Published 2009 Journal Neuroscience Section Abstract Doc Link 19772896 Disease Relevance 0.52 Pain Relevance 0.71
Here, we investigate the effects of pentoxifylline on the hypotension, vascular hyporeactivity to noradrenaline, release of tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO), and inducible NO synthase protein expression in a rat model of circulatory shock induced by bacterial endotoxin (Escherichia coli lipopolysaccharide).
Positive_regulation (inducible) of Gene_expression (expression) of NO synthase protein associated with necrosis, pressure volume 2 under development, cv general 2 under development, cancer and noradrenaline
2) Confidence 0.21 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408250 Disease Relevance 0.74 Pain Relevance 0.09
In lipopolysaccharide-rats pretreated with pentoxifylline, inducible NO synthase protein expression in lung homogenates was attenuated by 48 +/- 5%.
Positive_regulation (inducible) of Gene_expression (expression) of NO synthase protein in lung
3) Confidence 0.14 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408250 Disease Relevance 0.20 Pain Relevance 0.10

General Comments

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