INT82866

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 6.95
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus 3
plasma 1
skeletal muscles 1
internal 1
external 1
Atp9a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 4 100.00 Very High Very High Very High
Hyperalgesia 17 97.36 Very High Very High Very High
Stimulus evoked pain 2 88.64 High High
rheumatoid arthritis 148 76.32 Quite High
Lasting pain 12 75.80 Quite High
Inflammation 79 68.12 Quite High
Osteoarthritis 72 67.52 Quite High
Antihyperalgesic 4 60.28 Quite High
Spinal cord 39 54.20 Quite High
cytokine 31 53.96 Quite High
Disease Link Frequency Relevance Heat
Disease 88 100.00 Very High Very High Very High
Bacteremia 62 99.48 Very High Very High Very High
Celiac Disease 84 99.46 Very High Very High Very High
Infection 175 99.24 Very High Very High Very High
Ganglion Cysts 4 98.72 Very High Very High Very High
Ataxia 44 97.92 Very High Very High Very High
Hyperalgesia 31 97.36 Very High Very High Very High
Diabetes Mellitus 6 94.40 High High
Generalized Anxiety Disorder 2 92.16 High High
Hypersensitivity 13 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During embryogenesis, type IIA procollagen is localized around cells of the developing ganglion cell layer [30], playing a role in guiding the axonal processes of the developing retinal ganglion cells as they traverse the retinal surface and converge to form the optic nerve bundle [31].
Localization (localized) of IIA in retinal ganglion cells associated with ganglion cysts
1) Confidence 0.78 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.82 Pain Relevance 0
Effects of escins Ia, Ib, IIa, and IIb isolated from horse chestnuts on ethanol-induced gastric mucosal lesions and the roles of capsaicin-sensitive afferent neurons, endogenous nitric oxide (NO), sulfhydryls, prostaglandins, as well as gastric secretion and the sympathetic nervous system, were investigated in rats.
Localization (secretion) of IIa in afferent neurons associated with qutenza
2) Confidence 0.62 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10408252 Disease Relevance 0 Pain Relevance 0.16
These results are not very different from those observed in a larger study.9,12 The independent risk factors for bacteremia were age above 55 years, catheterization for more than 22 days, UNOS class IIA, and posttransplant hemodialysis.
Localization (catheterization) of IIA associated with bacteremia
3) Confidence 0.34 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649862 Disease Relevance 1.05 Pain Relevance 0
Survival rates were similar among patients with IA, IB and IIA disease (log rank p(IA vs.
Localization (disease) of IIA associated with disease
4) Confidence 0.19 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.16 Pain Relevance 0
First, class IIa HDAC members are actively exported from the nucleus [14,15,77], which provides the opportunity for these enzymes to act on non-nuclear proteins that have been acetylated.
Localization (exported) of IIa in nucleus
5) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 0.53 Pain Relevance 0.50
Four MHC isoforms (I, IIA, IIX, and embryonic), which migrated on electrophoresis as IIA-embryonic-IIX-I from slowest to fastest [11,12], were detected in canine skeletal muscles (Fig. 7A).
Localization (migrated) of IIA in skeletal muscles
6) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2257929 Disease Relevance 0 Pain Relevance 0
The cellular sublocalization of HDAC class I is constitutively nuclear and dynamically affects gene regulation, while HDAC class II translocates from the cytoplasm to the nucleus in response to external stimuli.
Localization (translocates) of class II in external
7) Confidence 0.02 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.08 Pain Relevance 0
Class II HDACs (HDACs 4 to 7 and 9), homologues of yeast Hda1, are found in both the nucleus and the cytoplasm.
Localization (found) of Class II in nucleus
8) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.10 Pain Relevance 0.42
Class II HDACs (HDACs 4 to 7 and 9), homologues of yeast Hda1, are found in both the nucleus and the cytoplasm.
Localization (found) of Class II in nucleus
9) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.10 Pain Relevance 0.42
In conclusion, anti-neural reactivity in CD patients is linked to the presence of class2 anti-TG2-TG3-TG6 antibodies that are able to cause ataxia.
Localization (presence) of class2 in neural associated with celiac disease and ataxia
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.81 Pain Relevance 0.03
Confocal images show localization of both class1 and class2 on vessels structures (Figure 6A, B) and confirmed our finding that the two scFv classes have a distinct staining pattern, with class1 binding the more external layers and class2 the more internal layers.
Localization (localization) of class2 in internal
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.12 Pain Relevance 0.03
As a consequence of infection, LC3, LAMP1 and MHC class II molecules are retained within the H. pylori-containing vacuoles and export of MHC class II molecules to cell surface is blocked.
Localization (export) of class II associated with infection
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2877707 Disease Relevance 0.83 Pain Relevance 0
In addition, MHC class II molecule export to the cell surface is blocked, which results in an impaired antigen presentation.
Localization (export) of class II
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.36 Pain Relevance 0
IL-10 has been found to down-regulate the MHC class II export to plasma membrane, probably via inhibition of cathepsin S [32], [33].
Localization (export) of class II in plasma
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0 Pain Relevance 0

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