INT82878

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 4
Speculated 12
Reported most in Abstract
Documents 201
Total Number 217
Disease Relevance 164.95
Pain Relevance 101.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 36
macrophages 22
neurons 11
DRG 9
endothelial cells 7
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 3541 100.00 Very High Very High Very High
Inflammation 2894 100.00 Very High Very High Very High
cytokine 680 100.00 Very High Very High Very High
dorsal root ganglion 500 100.00 Very High Very High Very High
Eae 307 100.00 Very High Very High Very High
metalloproteinase 24 100.00 Very High Very High Very High
Sciatic nerve 523 99.96 Very High Very High Very High
Snapping jaw 8 99.84 Very High Very High Very High
Pain 720 99.82 Very High Very High Very High
nociceptor 180 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3377 100.00 Very High Very High Very High
Nervous System Injury 1075 100.00 Very High Very High Very High
Injury 1053 100.00 Very High Very High Very High
Ganglion Cysts 528 100.00 Very High Very High Very High
Adhesions 200 100.00 Very High Very High Very High
Necrosis 115 100.00 Very High Very High Very High
Cancer 81 100.00 Very High Very High Very High
Reperfusion Injury 29 99.98 Very High Very High Very High
Stress 226 99.96 Very High Very High Very High
Hypertension 551 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using immunohistochemical studies, we first show that CCL2 is constitutively expressed by primary afferent neurons and their processes in the dorsal horn of the spinal cord.
Gene_expression (expressed) of CCL2 in spinal cord associated with dorsal horn and spinal cord
1) Confidence 0.78 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18419759 Disease Relevance 0.56 Pain Relevance 0.97
While in the early post-operative time course, CCL2 and CCR2 were expressed in astroglia and granulocytes only on level T9; there was additional astroglial CCL2 expression in dorsal columns and dorsal horns above and below T9 of severely injured animals 42d after lesion.
Gene_expression (expression) of CCL2 in dorsal
2) Confidence 0.78 Published 2008 Journal J. Neurotrauma Section Abstract Doc Link 18338959 Disease Relevance 1.36 Pain Relevance 1.02
In parallel expression of CCL2/CCR2 on cervical, thoracic, and lumbar levels was investigated by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry early (7 days [7d]), intermediate (15d), and late (42d) after lesion.
Gene_expression (expression) of CCL2 in thoracic
3) Confidence 0.78 Published 2008 Journal J. Neurotrauma Section Abstract Doc Link 18338959 Disease Relevance 1.36 Pain Relevance 0.82
Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat.
Gene_expression (expression) of CCL2 in spinal cord associated with pain, central pain, inflammation, injury, neuropathic pain and spinal cord
4) Confidence 0.78 Published 2008 Journal J. Neurotrauma Section Title Doc Link 18338959 Disease Relevance 1.44 Pain Relevance 1.18
The focus of the current study was the investigation of time-dependent CCL2 and CCR2 expression in relation to central neuropathic pain development after spinal cord impact lesions of 100, 150, or 200 kdyn force on spinal cord level T9 in adult rats.
Gene_expression (expression) of CCL2 in spinal cord associated with neuropathic pain and spinal cord
5) Confidence 0.78 Published 2008 Journal J. Neurotrauma Section Abstract Doc Link 18338959 Disease Relevance 1.23 Pain Relevance 0.78
While in the early post-operative time course, CCL2 and CCR2 were expressed in astroglia and granulocytes only on level T9; there was additional astroglial CCL2 expression in dorsal columns and dorsal horns above and below T9 of severely injured animals 42d after lesion.
Gene_expression (expressed) of CCL2 in dorsal
6) Confidence 0.78 Published 2008 Journal J. Neurotrauma Section Abstract Doc Link 18338959 Disease Relevance 1.40 Pain Relevance 0.95
In this study, we examined the production of monocyte chemoattractant protein-1 (MCP-1), a well-characterized chemokine, in dorsal root ganglia (DRG) in a rat model of neuropathic pain.
Spec (examined) Gene_expression (production) of MCP-1 in dorsal root ganglia associated with chemokine and neuropathic pain
7) Confidence 0.77 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.51 Pain Relevance 0.60
These results suggest that MCP-1 produced in the DRG neurons is involved in the development of mechanical allodynia induced by nerve injury.
Gene_expression (produced) of MCP-1 in neurons associated with nervous system injury and allodynia
8) Confidence 0.77 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.53 Pain Relevance 0.64
In situ hybridization histochemistry showed that MCP-1 mRNA expression was markedly upregulated in the ipsilateral DRG with weaker increase in the contralateral one at 24 h after the ligation, indicating that the elevation in MCP-1ir detected by immunohistochemistry was due to an upregulation of MCP-1 production by the DRG neurons themselves.
Gene_expression (production) of MCP-1 in neurons
9) Confidence 0.77 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.40 Pain Relevance 0.67
Peripheral inflammation increases Scya2 expression in sensory ganglia and cytokine and endothelial related gene expression in inflamed tissue.
Gene_expression (expression) of Scya2 in ganglia associated with inflammation and cytokine
10) Confidence 0.77 Published 2007 Journal J. Neurochem. Section Title Doc Link 17883394 Disease Relevance 0.82 Pain Relevance 0.76
Our results demonstrate that MCP-1 synthesized in DRG neurons may or may not be transported to the spinal cord depending on the type of peripheral nerve injury.
Gene_expression (synthesized) of MCP-1 in neurons associated with dorsal root ganglion, nervous system injury, peripheral nerve injury and spinal cord
11) Confidence 0.77 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.32 Pain Relevance 1.09
Spinal expression of MCP-1 peaked when mechanical allodynia was maximal, but then declined rapidly despite the remarkable persistence of mechanical allodynia.
Gene_expression (expression) of MCP-1 in Spinal associated with allodynia
12) Confidence 0.77 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.30 Pain Relevance 0.95
MCP-1 expression in the DRG peaked and declined before the full onset of pain hypersensitivity following nerve injury.
Gene_expression (expression) of MCP-1 in DRG associated with dorsal root ganglion, nervous system injury, hypersensitivity and stimulus evoked pain
13) Confidence 0.77 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.21 Pain Relevance 0.90
In this study, we evaluated the expression of MCP-1 in the rat dorsal root ganglion (DRG) and spinal cord following axotomy and chronic constriction injury (CCI) of the sciatic nerve and L5 spinal nerve ligation (L5 SNL) using an immunohistochemical approach.
Gene_expression (expression) of MCP-1 in sciatic nerve associated with ganglion cysts, dorsal root ganglion, eae, injury, sciatic nerve and spinal cord
14) Confidence 0.77 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 0.96 Pain Relevance 0.76
MCP-1 production in temporomandibular joint inflammation.
Gene_expression (production) of MCP-1 in temporomandibular joint associated with snapping jaw, inflammation and cytokine
15) Confidence 0.76 Published 2010 Journal J. Dent. Res. Section Title Doc Link 20647497 Disease Relevance 0.77 Pain Relevance 0.62
The jejunal muscularis was studied for cytokine mRNA expressions [interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, inducible nitric oxide synthase, cyclooxygenase-2, biliverdin, IL-10, and HO-1] using real-time RT-PCR.
Gene_expression (expressions) of monocyte chemoattractant protein in monocyte associated with cytokine
16) Confidence 0.75 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16537973 Disease Relevance 0.67 Pain Relevance 0.35
Subsequently, cultured rat PSCs were exposed to CM and tested to see whether their proliferation, MCP-1 production and procollagen alpha1 messenger RNA expression was influenced by CM.
Gene_expression (production) of MCP-1 in PSCs
17) Confidence 0.75 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.80 Pain Relevance 0.40
The in vitro study revealed that CM inhibited both MCP-1 and TNF-alpha production from monocytes, and proliferation and MCP-1 production from PSCs.
Gene_expression (production) of MCP-1 in monocytes
18) Confidence 0.75 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.69 Pain Relevance 0.35
Thereafter, the effect of CM on monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) production from monocytes was examined.
Gene_expression (production) of MCP-1 in monocyte associated with necrosis and cancer
19) Confidence 0.75 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.82 Pain Relevance 0.40
The in vitro study revealed that CM inhibited both MCP-1 and TNF-alpha production from monocytes, and proliferation and MCP-1 production from PSCs.
Gene_expression (production) of MCP-1 in monocytes
20) Confidence 0.75 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.67 Pain Relevance 0.34

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