INT82879

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.19
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) aging (Ccl5) extracellular region (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
T cell 4
macrophage 1
internal jugular 1
kidney 1
Ccl5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 147 100.00 Very High Very High Very High
Inflammation 39 99.46 Very High Very High Very High
Migraine 4 98.42 Very High Very High Very High
adenocard 2 96.86 Very High Very High Very High
MU agonist 1 96.72 Very High Very High Very High
Calcitonin gene-related peptide 2 95.88 Very High Very High Very High
Enkephalin 1 94.72 High High
Neuritis 6 94.40 High High
Neuropathic pain 16 87.96 High High
Sciatic nerve 16 87.24 High High
Disease Link Frequency Relevance Heat
Adhesions 6 100.00 Very High Very High Very High
INFLAMMATION 42 99.46 Very High Very High Very High
Disease 19 99.04 Very High Very High Very High
Epilepsy 2 98.86 Very High Very High Very High
Hypertension 104 98.80 Very High Very High Very High
Headache 2 98.42 Very High Very High Very High
Diabetes Mellitus 116 98.16 Very High Very High Very High
Immunization 5 98.04 Very High Very High Very High
Experimental Autoimmune Neuritis 6 94.40 High High
Renal Disease 2 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the chemokine RANTES or the adhesion molecules ICAM-1 and VCAM-1 were not transcriptionally regulated in the kidney in response to hypertension or diabetes (table 2).
Neg (not) Regulation (regulated) of RANTES in kidney associated with chemokine, diabetes mellitus, hypertension and adhesions
1) Confidence 0.30 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.16 Pain Relevance 0.09
Interferon-gamma-inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, the regulated upon activation normal T cell expressed and secreted chemokine (RANTES), and lymphotactin were analyzed on days 0 (pre-immunization), 7 (preclinical stage), 10 (disease onset), 13 (clinical progression), 17 (disease peak), as well as on days 20, 24, and 34 post-immunization (p.i.)
Regulation (regulated) of cell expressed and secreted in T cell associated with chemokine, inflammation, immunization and disease
2) Confidence 0.20 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10408979 Disease Relevance 0.73 Pain Relevance 0.46
Interferon-gamma-inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, the regulated upon activation normal T cell expressed and secreted chemokine (RANTES), and lymphotactin were analyzed on days 0 (pre-immunization), 7 (preclinical stage), 10 (disease onset), 13 (clinical progression), 17 (disease peak), as well as on days 20, 24, and 34 post-immunization (p.i.)
Regulation (regulated) of RANTES in T cell associated with chemokine, inflammation, immunization and disease
3) Confidence 0.20 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10408979 Disease Relevance 0.74 Pain Relevance 0.46
-inducing protein-10 (IP-10/CXCL10), regulated on activation normal T cell expressed and released (RANTES/CCL5) and stromal cell derived factor-1 (SDF1/CXCL12) and their cognate receptors (CCR2, CXCR3, CCR5 and CXCR4, respectively).
Regulation (regulated) of RANTES in T cell
4) Confidence 0.16 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.82 Pain Relevance 0.89
Expression of mediators regulating macrophage infiltration (MCP-1, osteopontin, RANTES) and adhesion molecules involved in macrophage infiltration (ICAM-1, VCAM-1) was investigated to further elucidate inflammatory pathways in hypertensive and diabetic renal disease: In TGR rats, renal MCP-1 and osteopontin mRNA steady state levels were increased compared to SD controls, as determined by real-time RT-PCR (figure 3A and 3B).
Regulation (regulating) of RANTES in macrophage associated with inflammation, diabetes mellitus, renal disease, hypertension and adhesions
5) Confidence 0.15 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.56 Pain Relevance 0.08
Spontaneously proliferating HaCaT cells, showing several similarities to basal epidermal keratinocytes, were found to respond to external chemoattractants, including the chemokines RANTES (regulated on activation normal T cell expressed and secreted) and interleukin-8 and the mu-opioid agonist DAMGO ([d-ala2, N-Me-Phe4, Gly-ol5]enkephalin) in migration assays.
Regulation (regulated) of RANTES in T cell associated with chemokine, mu agonist and enkephalin
6) Confidence 0.11 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11710916 Disease Relevance 0.17 Pain Relevance 0.28
OBJECTIVE: To investigate changes in the levels of calcitonin gene-related peptide and its intracellular messenger cyclic adenosine monophosphate in serial samples of internal jugular blood taken from migraine patients without aura assessed during attacks, and to assess their relationship with the levels of IL-8, MCP-1, and RANTES in the same samples.
Regulation (relationship) of RANTES in internal jugular associated with epilepsy, adenocard, migraine and calcitonin gene-related peptide
7) Confidence 0.04 Published 2004 Journal Headache Section Abstract Doc Link 15546258 Disease Relevance 0.27 Pain Relevance 0.31
In contrast, mRNAs for MCP-1, RANTES, and IP-10 exhibited peak levels coincident with peak of the disease at day 15 p.i.
Regulation (mRNAs) of RANTES associated with disease
8) Confidence 0.04 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.74 Pain Relevance 0.60
A transient increase in IL-8 was observed at the 2nd and 4th hours (P<.01 and P<.002, respectively), whereas no changes in the levels of MCP-1 and RANTES were found at any time of the study.
Neg (no) Regulation (changes) of RANTES
9) Confidence 0.03 Published 2004 Journal Headache Section Body Doc Link 15546258 Disease Relevance 0 Pain Relevance 0

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