INT82880

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.65
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
neurons 4
T cell 2
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 60 100.00 Very High Very High Very High
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
chemokine 67 99.96 Very High Very High Very High
Kinase C 3 98.52 Very High Very High Very High
qutenza 7 98.00 Very High Very High Very High
dorsal root ganglion 47 96.72 Very High Very High Very High
Neuritis 2 96.72 Very High Very High Very High
Hyperalgesia 1 95.92 Very High Very High Very High
Inflammatory mediators 6 91.28 High High
Calcium channel 1 91.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 81 100.00 Very High Very High Very High
Immunization 2 97.32 Very High Very High Very High
Ganglion Cysts 47 96.72 Very High Very High Very High
Experimental Autoimmune Neuritis 2 96.72 Very High Very High Very High
Hyperalgesia 6 95.92 Very High Very High Very High
Disease 5 95.64 Very High Very High Very High
Bordatella Infection 1 85.08 High High
Nociception 10 75.00 Quite High
Pleurisy 13 74.24 Quite High
Injury 37 72.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interferon-gamma-inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, the regulated upon activation normal T cell expressed and secreted chemokine (RANTES), and lymphotactin were analyzed on days 0 (pre-immunization), 7 (preclinical stage), 10 (disease onset), 13 (clinical progression), 17 (disease peak), as well as on days 20, 24, and 34 post-immunization (p.i.)
Positive_regulation (regulated) of Localization (secreted) of MCP in T cell associated with chemokine, inflammation, immunization and disease
1) Confidence 0.49 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10408979 Disease Relevance 0.74 Pain Relevance 0.47
Pretreatment of DRG neurons for 30 min with the inhibitors of phospholipase C (PLC) and protein kinase C (PKC) but not mitogen-activated protein kinases (MAPKs) significantly reduced CCL2- or CXCL1-induced CGRP release and intracellular calcium elevation.
Positive_regulation (elevation) of Localization (release) of CCL2 in neurons associated with dorsal root ganglion, kinase c and calcitonin gene-related peptide
2) Confidence 0.48 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.79 Pain Relevance 1.14
-induced MCP-1 mRNA expression and MCP-1 protein secretion [68].
Positive_regulation (induced) of Localization (secretion) of MCP-1 protein
3) Confidence 0.23 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.71 Pain Relevance 0.25
Furthermore, most of the cells responding to MCP1 and SDF1 application were neurons, based on their response profile to capsaicin, high K+ and ATP (Table 3).
Positive_regulation (responding) of Localization (application) of MCP1 in neurons associated with qutenza
4) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.42 Pain Relevance 0.45

General Comments

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