INT82881

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 15.29
Pain Relevance 7.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 3
sensory neurons 1
macrophage 1
spinal cord 1
Spinal 1
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 197 100.00 Very High Very High Very High
Pain 39 99.84 Very High Very High Very High
antagonist 101 99.28 Very High Very High Very High
anesthesia 10 99.04 Very High Very High Very High
dorsal root ganglion 85 98.72 Very High Very High Very High
chemokine 276 97.84 Very High Very High Very High
qutenza 23 97.40 Very High Very High Very High
Spinal cord 49 96.88 Very High Very High Very High
Neuritis 14 96.72 Very High Very High Very High
antinociception 4 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 279 100.00 Very High Very High Very High
Pain 51 99.84 Very High Very High Very High
Cancer 10 99.48 Very High Very High Very High
Status Epilepticus 424 99.36 Very High Very High Very High
Necrosis 10 99.24 Very High Very High Very High
Adhesions 11 98.92 Very High Very High Very High
Ganglion Cysts 86 98.72 Very High Very High Very High
Nervous System Injury 50 98.44 Very High Very High Very High
Diabetes Mellitus 176 98.24 Very High Very High Very High
Syndrome 10 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of mediators regulating macrophage infiltration (MCP-1, osteopontin, RANTES) and adhesion molecules involved in macrophage infiltration (ICAM-1, VCAM-1) was investigated to further elucidate inflammatory pathways in hypertensive and diabetic renal disease: In TGR rats, renal MCP-1 and osteopontin mRNA steady state levels were increased compared to SD controls, as determined by real-time RT-PCR (figure 3A and 3B).
Regulation (regulating) of MCP-1 in macrophage associated with inflammation, diabetes mellitus, renal disease, hypertension and adhesions
1) Confidence 0.57 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.55 Pain Relevance 0.07
Therefore, we wished to see whether MCP-1 activity was altered in the L4/L5 DRG contralateral to the nerve injury.
Spec (whether) Regulation (altered) of MCP-1 in nerve associated with nervous system injury
2) Confidence 0.53 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.50 Pain Relevance 0.16
Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats.
Regulation (effective) of CCL2 in Spinal associated with antagonist
3) Confidence 0.45 Published 2008 Journal J. Neurochem. Section Title Doc Link 18419759 Disease Relevance 0.51 Pain Relevance 0.88
Further elucidation of the regulation and coordination of MIP-1alpha and MCP-1 production may lead to new therapeutic approaches to GBS in humans.
Regulation (regulation) of MCP-1 associated with syndrome
4) Confidence 0.43 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10430050 Disease Relevance 1.24 Pain Relevance 1.17
STZ-induced diabetes mellitus of five weeks did not significantly increase MCP-1 and osteopontin mRNA in SD rats and did not augment the upregulation of MCP-1 mRNA in TGR (figure 3).
Regulation (upregulation) of MCP-1 associated with diabetes mellitus
5) Confidence 0.42 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.11 Pain Relevance 0.09
Interferon-gamma-inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, the regulated upon activation normal T cell expressed and secreted chemokine (RANTES), and lymphotactin were analyzed on days 0 (pre-immunization), 7 (preclinical stage), 10 (disease onset), 13 (clinical progression), 17 (disease peak), as well as on days 20, 24, and 34 post-immunization (p.i.)
Regulation (regulated) of MCP in T cell associated with chemokine, inflammation, immunization and disease
6) Confidence 0.26 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10408979 Disease Relevance 0.73 Pain Relevance 0.44
In our study, a novel selective pharmacological tool, AZ889, was used to characterize the CCL2/CCR2 effects on pain processing cells and to show that these effects, particularly in the spinal cord, could account for AZ889-mediated antinociception.
Regulation (effects) of CCL2 in spinal cord associated with antinociception, pain and spinal cord
7) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 1.16 Pain Relevance 1.00
Thereafter, the effect of CM on monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) production from monocytes was examined.
Spec (examined) Regulation (effect) of monocyte chemoattractant protein-1 in monocyte associated with necrosis and cancer
8) Confidence 0.23 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.82 Pain Relevance 0.38
Results show that the effect of high glucose on lipid peroxidation, IL-6, IL-8, MCP-1, and TNF-alpha secretion was inhibited by curcumin in cultured monocytes.
Regulation (effect) of MCP-1 in monocytes
9) Confidence 0.22 Published 2009 Journal Antioxid. Redox Signal. Section Abstract Doc Link 18976114 Disease Relevance 0.58 Pain Relevance 0.17
In our study the association between MCP-1 and abnormal glucose regulation was present in the majority of the patients, but not in patients with triglycerides above 1.8 mmol/L, suggesting that in these patients the high levels of triglycerides may mask the association between MCP-1 and glucose regulation.
Regulation (regulation) of MCP-1
10) Confidence 0.20 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.66 Pain Relevance 0.03
In our study the association between MCP-1 and abnormal glucose regulation was present in the majority of the patients, but not in patients with triglycerides above 1.8 mmol/L, suggesting that in these patients the high levels of triglycerides may mask the association between MCP-1 and glucose regulation.
Regulation (regulation) of MCP-1
11) Confidence 0.20 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.89 Pain Relevance 0.06
The present study investigated the effects of intracisternal administration of MCP-1, Rantes or IL-8 on pain transmission in the orofacial area.
Spec (investigated) Regulation (effects) of MCP-1 associated with pain
12) Confidence 0.20 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 15925144 Disease Relevance 0.27 Pain Relevance 0.18
In BzATP-infused animals, MCP-1 immunoreactivity was observed at 12 hr after SE (Figure 7B1).
Regulation (immunoreactivity) of MCP-1 associated with status epilepticus
13) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.97 Pain Relevance 0
In addition, P2X7 receptor-mediated MCP-1 (released from microglia)/MIP-2 (released from astrocytes) regulation was related to SE-induced leukocyte infiltration in an IL-1?
Regulation (regulation) of MCP-1 in leukocyte associated with status epilepticus
14) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2964655 Disease Relevance 0.62 Pain Relevance 0.12
In the present study, MCP-1 immunoreactivity was detected in microglia, and CCR2 immunoreactivity was colocalized with MIP-2 immunoreactivity in astrocytes and neurons after SE.
Regulation (immunoreactivity) of MCP-1 in neurons associated with status epilepticus
15) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.51 Pain Relevance 0.08
VEGF and MCP-1 mRNA levels were not significantly affected in these animals.
Neg (not) Regulation (affected) of MCP-1 mRNA
16) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 0.94 Pain Relevance 0.24
In addition, inhibition of endogenous NO synthesis by L-NNA increased endothelial MCP-1 mRNA expression and resulted in a marked increase in monocyte chemotactic activity [57], suggesting that NO modulates MCP-1 expression and activity in vitro.
Regulation (modulates) of MCP-1 in monocyte
17) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.33 Pain Relevance 0.28
Hence, the observed upregulation of responses to SDF1 and MCP1 application agreed with the anatomical observations on receptor expression described above.


Regulation (responses) of MCP1
18) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.48 Pain Relevance 0.46
In the present study, MCP-1 immunoreactivity was detected in microglia, and CCR2 immunoreactivity was colocalized with MIP-2 immunoreactivity in astrocytes and neurons after SE.
Regulation (immunoreactivity) of MCP-1 in astrocytes associated with status epilepticus
19) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.51 Pain Relevance 0.08
The effect of troglitazone on alpha1(I) procollagen mRNA and MCP-1 mRNA was unaffected by inhibition of endogenous PPARgamma1 receptor activity.
Regulation (effect) of MCP-1 mRNA
20) Confidence 0.05 Published 2004 Journal Pancreas Section Abstract Doc Link 15211114 Disease Relevance 0.35 Pain Relevance 0.43

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