INT82882

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Context Info
Confidence 0.80
First Reported 1999
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 61
Total Number 63
Disease Relevance 41.96
Pain Relevance 28.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
neurons 14
monocyte 7
podocytes 2
blood 2
vesicles 2
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 861 100.00 Very High Very High Very High
Inflammation 602 100.00 Very High Very High Very High
cytokine 306 100.00 Very High Very High Very High
dorsal root ganglion 277 100.00 Very High Very High Very High
Neuropathic pain 171 100.00 Very High Very High Very High
Dorsal horn 92 100.00 Very High Very High Very High
Spinal cord 78 100.00 Very High Very High Very High
nociceptor 63 100.00 Very High Very High Very High
Calcitonin gene-related peptide 40 100.00 Very High Very High Very High
hyperexcitability 25 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 711 100.00 Very High Very High Very High
Ganglion Cysts 284 100.00 Very High Very High Very High
Neuropathic Pain 229 100.00 Very High Very High Very High
Nociception 117 99.96 Very High Very High Very High
Status Epilepticus 742 99.92 Very High Very High Very High
Hyperoxia 98 99.78 Very High Very High Very High
Pain 228 99.76 Very High Very High Very High
Injury 383 99.70 Very High Very High Very High
Nervous System Injury 184 99.54 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

92 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also observe that CCL2 is co-localized with pain-related peptides (SP and CGRP) and capsaicin receptor (VR1).
Localization (localized) of CCL2 associated with pain and qutenza
1) Confidence 0.80 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18419759 Disease Relevance 0.63 Pain Relevance 1.09
Accordingly, using in vitro superfusion system of lumbar dorsal root ganglion and spinal cord explants of healthy rats, we show that potassium or capsaicin evoke calcium-dependent release of CCL2.
Localization (release) of CCL2 in spinal cord associated with ganglion cysts, dorsal root ganglion, qutenza and spinal cord
2) Confidence 0.80 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18419759 Disease Relevance 0.66 Pain Relevance 1.20
PLC-, PKC-, and calcium-induced calcium release from ryanodine-sensitive calcium stores signaling pathways are involved in CCL2- and CXCL1-induced CGRP release from primary nociceptive neurons, in which chemokines produce painful effects via direct actions on chemokine receptors expressed by nociceptive neurons.
Localization (release) of CCL2 in neurons associated with nociception, pain, chemokine, kinase c and calcitonin gene-related peptide
3) Confidence 0.77 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.76 Pain Relevance 1.03
CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons.
Localization (release) of CCL2 in neurons associated with nociception, nociceptor and calcitonin gene-related peptide
4) Confidence 0.77 Published 2005 Journal J. Neurosci. Res. Section Title Doc Link 16047385 Disease Relevance 0.72 Pain Relevance 1.00
Whole-cell patch-clamp recordings revealed that CCL2, a ligand for CCR2 receptor, depolarized nociceptive DRG neurons from rats of the all three models.
Localization (depolarized) of CCL2 in neurons associated with nociception
5) Confidence 0.75 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20346391 Disease Relevance 0.90 Pain Relevance 0.41
Our results demonstrate that MCP-1 synthesized in DRG neurons may or may not be transported to the spinal cord depending on the type of peripheral nerve injury.
Neg (not) Localization (transported) of MCP-1 in neurons associated with dorsal root ganglion, nervous system injury, peripheral nerve injury and spinal cord
6) Confidence 0.74 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.32 Pain Relevance 1.10
Our results demonstrate that MCP-1 synthesized in DRG neurons may or may not be transported to the spinal cord depending on the type of peripheral nerve injury.
Spec (may) Localization (may) of MCP-1 in neurons associated with dorsal root ganglion, nervous system injury, peripheral nerve injury and spinal cord
7) Confidence 0.74 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.32 Pain Relevance 1.09
The pattern of immunostaining suggested a predominantly podocyte and occasionally endothelial localization of MCP-1 (figure 5).
Localization (localization) of MCP-1 in podocyte
8) Confidence 0.74 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 0.45 Pain Relevance 0
Interferon-gamma-inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, the regulated upon activation normal T cell expressed and secreted chemokine (RANTES), and lymphotactin were analyzed on days 0 (pre-immunization), 7 (preclinical stage), 10 (disease onset), 13 (clinical progression), 17 (disease peak), as well as on days 20, 24, and 34 post-immunization (p.i.)
Localization (secreted) of MCP in T cell associated with chemokine, inflammation, immunization and disease
9) Confidence 0.73 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10408979 Disease Relevance 0.74 Pain Relevance 0.47
Pretreatment of DRG neurons for 30 min with the inhibitors of phospholipase C (PLC) and protein kinase C (PKC) but not mitogen-activated protein kinases (MAPKs) significantly reduced CCL2- or CXCL1-induced CGRP release and intracellular calcium elevation.
Localization (release) of CCL2 in neurons associated with dorsal root ganglion, kinase c and calcitonin gene-related peptide
10) Confidence 0.72 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.78 Pain Relevance 1.13
In addition to the chronic maintenance of sensory neuron hyperexcitability, release of chemokines such as MCP-1 and fracktalkine from central axon terminals in the spinal cord may initiate microglial-mediated neuropathic pain states [7,11,42-44].
Localization (release) of MCP-1 in spinal cord associated with chemokine, neuropathic pain, hyperexcitability and spinal cord
11) Confidence 0.69 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.50 Pain Relevance 0.94
The CGRP release by CCL2 and CXCL1 was significantly inhibited by EGTA, omega-conotoxin GVIA (an N-type calcium channel blocker), thapsigargin, and ryanodine.
Localization (release) of CCL2 associated with calcium channel, conotoxin and calcitonin gene-related peptide
12) Confidence 0.68 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.71 Pain Relevance 0.96
The localization of MCP-1 was studied by immunohistochemistry.


Localization (localization) of MCP-1
13) Confidence 0.65 Published 2005 Journal BMC Nephrol Section Abstract Doc Link PMC1175090 Disease Relevance 1.57 Pain Relevance 0.04
Interestingly, glomerular MCP-1 was localized in podocytes, similar to the localization of osteopontin in glomeruli of diabetic TGR described by Kelly et al. [13].
Localization (localized) of MCP-1 in podocytes associated with diabetes mellitus
14) Confidence 0.65 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.37 Pain Relevance 0.11
The diameter of MCP-1 immunoreactive neurons in the LPC-treated animals averaged 26.49 ± 0.47 ?
Localization (diameter) of MCP-1 in neurons
15) Confidence 0.65 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.25 Pain Relevance 0.39
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Localization (released) of MCP1 in vesicles associated with chemokine
16) Confidence 0.65 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.29 Pain Relevance 0.58
It was evident that an increased number of cells responded to MCP-1 application from POD 14–28 in the DRG cells ipsilateral to the nerve injury (Fig. 9B and 9C), (Table 1), when compared to vehicle-treated control animals (Fig 9A).
Localization (application) of MCP-1 in nerve associated with nervous system injury
17) Confidence 0.65 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.10 Pain Relevance 0.65
Scya2 mRNA was localized to a subpopulation of vanilloid receptor 1 (TRPV1) containing neurons.
Localization (localized) of Scya2 mRNA in neurons
18) Confidence 0.64 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.81 Pain Relevance 0.64
Here we show that the chemokine CCL2, produced by both damaged and undamaged primary sensory neurons in neuropathic pain states in rats, is released in an activity dependent manner from the central terminals of these fibres.
Localization (released) of CCL2 in primary sensory neurons associated with chemokine and neuropathic pain
19) Confidence 0.62 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18554968 Disease Relevance 0.52 Pain Relevance 0.60
RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1, but did not modify total protein secretion.
Localization (secretions) of MCP-1
20) Confidence 0.61 Published 2003 Journal Anesthesiology Section Body Doc Link 12502982 Disease Relevance 0 Pain Relevance 0

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