INT82883

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 105
Total Number 105
Disease Relevance 84.96
Pain Relevance 42.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 11
DRG 6
macrophage 4
kidney 3
spinal cord 3
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1100 100.00 Very High Very High Very High
chemokine 1024 100.00 Very High Very High Very High
cytokine 285 100.00 Very High Very High Very High
dorsal root ganglion 496 99.84 Very High Very High Very High
Peripheral nerve injury 48 99.66 Very High Very High Very High
Demyelination 167 99.58 Very High Very High Very High
qutenza 167 99.32 Very High Very High Very High
Eae 156 99.24 Very High Very High Very High
Hyperalgesia 126 99.24 Very High Very High Very High
Inflammatory response 144 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1519 100.00 Very High Very High Very High
Diabetes Mellitus 1375 100.00 Very High Very High Very High
Nervous System Injury 374 100.00 Very High Very High Very High
Adhesions 106 100.00 Very High Very High Very High
Stress 102 100.00 Very High Very High Very High
Urological Neuroanatomy 57 100.00 Very High Very High Very High
Injury 693 99.98 Very High Very High Very High
Hyperoxia 147 99.98 Very High Very High Very High
Hypertension 712 99.84 Very High Very High Very High
Neuropathic Pain 583 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization histochemistry showed that MCP-1 mRNA expression was markedly upregulated in the ipsilateral DRG with weaker increase in the contralateral one at 24 h after the ligation, indicating that the elevation in MCP-1ir detected by immunohistochemistry was due to an upregulation of MCP-1 production by the DRG neurons themselves.
Positive_regulation (elevation) of MCP-1ir in neurons
1) Confidence 0.69 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.42 Pain Relevance 0.67
In contrast, in DRG, only Scya2 (chemokine C-C motif ligand 2) mRNA was up-regulated, leading to an increase in its gene product monocyte chemoattractant protein-1.
Positive_regulation (up-regulated) of Scya2 in DRG associated with chemokine
2) Confidence 0.69 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17883394 Disease Relevance 0.73 Pain Relevance 0.55
Additionally, increased MCP-1 in both intact L4 and injured L5 DRG neurons may contribute to neuropathic pain hypersensitivity following L5 SNL.
Positive_regulation (increased) of MCP-1 in DRG associated with dorsal root ganglion, hypersensitivity, neuropathic pain and stimulus evoked pain
3) Confidence 0.69 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.53 Pain Relevance 1.05
Despite increased MCP-1 in small and large DRG neurons, a remarkable increase in MCP-1-IR terminals was observed in the spinal superficial laminae following CCI and L5SNL, but not following axotomy; however, in the deeper laminae, a considerable increase in MCP-1-IR terminals, which may originate from the large and injured L5 DRG neurons, was found after L5 SNL.
Positive_regulation (increased) of MCP-1 in DRG associated with dorsal root ganglion and eae
4) Confidence 0.69 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.43 Pain Relevance 1.12
We revealed nearly a 2-fold increase of MCP-1 plasma level in patients with unstable angina in comparison with patients with stable angina.
Positive_regulation (increase) of MCP-1 in plasma associated with angina
5) Confidence 0.67 Published 2007 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 17612642 Disease Relevance 1.08 Pain Relevance 0.62
MCP-1 was more markedly induced in hypertensive rats but the effects of hypertension and diabetes were not additive.
Positive_regulation (induced) of MCP-1 associated with diabetes mellitus and hypertension
6) Confidence 0.64 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.46 Pain Relevance 0.09
STZ-induced diabetes mellitus of five weeks did not significantly increase MCP-1 and osteopontin mRNA in SD rats and did not augment the upregulation of MCP-1 mRNA in TGR (figure 3).
Neg (not) Positive_regulation (increase) of MCP-1 associated with diabetes mellitus
7) Confidence 0.64 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.12 Pain Relevance 0.09
The finding that MCP-1 is likewise induced in renal mesangial cells by high glucose concentrations [6] is in keeping with the hypothesis that chronic inflammatory mechanisms may also contribute to the pathogenesis of diabetic nephropathy [7].
Positive_regulation (induced) of MCP-1 in mesangial cells associated with inflammation and diabetic nephropathy
8) Confidence 0.64 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.56 Pain Relevance 0.21
However, a more subtle investigation by means of immunohistochemistry clearly showed that MCP-1 was increased in glomeruli of normotensive, diabetic rats, in agreement with previous reports [8-12].
Positive_regulation (increased) of MCP-1 associated with diabetes mellitus
9) Confidence 0.64 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.34 Pain Relevance 0.06
Real-time RT-PCR did not detect an induction of MCP-1 in total cortical RNA of kidney of normotensive, diabetic rats.
Positive_regulation (induction) of MCP-1 in kidney associated with diabetes mellitus
10) Confidence 0.64 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.32 Pain Relevance 0.03
In contrast, in DRG, only Scya2 (chemokine C-C motif ligand 2) mRNA was up-regulated, leading to an increase in its gene product monocyte chemoattractant protein-1.
Positive_regulation (increase) of chemoattractant protein-1 in DRG associated with chemokine
11) Confidence 0.60 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17883394 Disease Relevance 0.72 Pain Relevance 0.62
The upregulation of MCP-1 and the CCR2 chemokine receptor observed in association with focal nerve demyelination is similar to the pattern we previously observed using a spinal stenosis model of neuropathic pain [8].
Positive_regulation (upregulation) of MCP-1 in spinal associated with chemokine, demyelination, neuropathic pain and spinal stenosis
12) Confidence 0.60 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.79 Pain Relevance 1.04
In a model where DRG inflammation was induced by administration of epidural zymosan in incomplete Freund's Adjuvant [7], an increase of CCL2 (MCP-1) among other cytokines was observed, while IL-2 and IL-12 were decreased on day 3 post inflammation.
Positive_regulation (increase) of CCL2 associated with inflammation, epidural and cytokine
13) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.95 Pain Relevance 0.71
In a model where DRG inflammation was induced by administration of epidural zymosan in incomplete Freund's Adjuvant [7], an increase of CCL2 (MCP-1) among other cytokines was observed, while IL-2 and IL-12 were decreased on day 3 post inflammation.
Positive_regulation (increase) of MCP-1 associated with inflammation, epidural and cytokine
14) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.95 Pain Relevance 0.71
MCP-1 levels have been reported to be elevated in patients with an acute myocardial infarction [22] and poor glycemic control has been suggested to induce high levels of MCP-1 in diabetic patients [23].
Positive_regulation (elevated) of MCP-1 associated with diabetes mellitus and myocardial infarction
15) Confidence 0.52 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.51 Pain Relevance 0.12
MCP-1 levels have been reported to be elevated in patients with an acute myocardial infarction [22] and poor glycemic control has been suggested to induce high levels of MCP-1 in diabetic patients [23].
Positive_regulation (induce) of MCP-1 associated with diabetes mellitus and myocardial infarction
16) Confidence 0.52 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.46 Pain Relevance 0.09
In that study, Scya2 mRNA was increased about 2-fold in the ipsilateral versus contralateral rat DRG and lasted up to 72 hour post carrageenan.
Positive_regulation (increased) of Scya2 mRNA
17) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.78 Pain Relevance 0.60
Thus, the injury-induced effects of CCL2 in increasing the excitability of the cell bodies of DRG neurons depend on the site of the injury--with greater effects occurring after an injury of the ganglion than after an injury of the spinal or peripheral nerve.
Positive_regulation (induced) of CCL2 in spinal associated with ganglion cysts and injury
18) Confidence 0.50 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20346391 Disease Relevance 1.29 Pain Relevance 0.41
Interferon-gamma-inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, the regulated upon activation normal T cell expressed and secreted chemokine (RANTES), and lymphotactin were analyzed on days 0 (pre-immunization), 7 (preclinical stage), 10 (disease onset), 13 (clinical progression), 17 (disease peak), as well as on days 20, 24, and 34 post-immunization (p.i.)
Positive_regulation (regulated) of MCP in T cell associated with chemokine, inflammation, immunization and disease
19) Confidence 0.49 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10408979 Disease Relevance 0.73 Pain Relevance 0.44
Intraplantar injection of CCL2 or CXCL1 produced hyperalgesia to thermal and mechanical stimulation in rats.
Positive_regulation (injection) of CCL2 associated with hyperalgesia
20) Confidence 0.48 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.77 Pain Relevance 1.12

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