INT82885

Context Info Confidence 0.65 First Reported 1999 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 7 Total Number 9 Disease Relevance 7.89 Pain Relevance 2.76

plasma membrane (Mip) transmembrane transport (Mip)

Anatomy Link Frequency macrophage 1 eye 1 retina 1 ganglion cells 1 neutrophils 1 Mip (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 57 100.00 chemokine 32 100.00 cva 144 99.74 cytokine 20 98.64 cINOD 2 96.12 Neuritis 3 95.08 Neuropeptide 1 93.20 diclofenac 10 92.64 Enkephalin 2 91.36 Inflammatory marker 2 88.76

Disease Link Frequency Relevance Heat INFLAMMATION 60 100.00 Subarachnoid Hemorrhage 140 99.74 Immunization 2 99.36 Disease 13 97.68 Adhesions 36 96.96 Ganglion Cysts 33 95.96 Experimental Autoimmune Neuritis 2 95.08 Cancer 2 92.64 Necrosis 2 92.16 Disorders Of The Lacrimal System 4 90.96

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Interferon-gamma-inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, the regulated upon activation normal T cell expressed and secreted chemokine (RANTES), and lymphotactin were analyzed on days 0 (pre-immunization), 7 (preclinical stage), 10 (disease onset), 13 (clinical progression), 17 (disease peak), as well as on days 20, 24, and 34 post-immunization (p.i.)

Spec (analyzed) Gene_expression (analyzed) of MIP in T cell associated with chemokine, inflammation, immunization and disease

1) Confidence 0.65 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10408979 Disease Relevance 0.74 Pain Relevance 0.47

The MIP was synthesized using 2-vinylpyridine (2-VP) and ethylene glycol dimethacrylate (EGDMA) as a functional monomer and cross-linker, respectively, and bulk thermal polymerization method. (1)H NMR spectroscopy was used to study the interaction between diclofenac and 2-VP mixed in toluene-d(8) in pre-polymerization complex.

Gene_expression (synthesized) of MIP associated with diclofenac

2) Confidence 0.57 Published 2008 Journal Anal. Chim. Acta Section Abstract Doc Link 18558126 Disease Relevance 0.10 Pain Relevance 0.44

AQP0 is expressed in lens fiber [12] and rodent bipolar cells [13,14] and has been reported in distinct amacrines and ganglion cells of the rat retina [14].

Gene_expression (expressed) of AQP0 in ganglion cells associated with ganglion cysts

3) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.60 Pain Relevance 0

Using Reverse-transcription-Polymerase Chain Reaction (RT–PCR), Tenckhoff et al. showed that human retina expresses mRNAs for AQP0 to AQP12, whereas rat retina has the mRNAs for AQP0, AQP1, AQP3, AQP4, AQP5, AQP6, AQP7, AQP8, AQP9, and AQP11.

Gene_expression (expresses) of AQP0 in retina

4) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.87 Pain Relevance 0

The same study reported that the human Müller cell line MIO-M1 [11] expressed mRNA for AQP0, AQP1, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10, and AQP11 but not AQP2, AQP6, and AQP12 [10].

Gene_expression (expressed) of AQP0

5) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.62 Pain Relevance 0

In addition, SAH increased the expression of the chemokines macrophage inflammatory protein (MIP)-1?

Gene_expression (expression) of MIP in macrophage associated with chemokine, inflammation and cva

6) Confidence 0.24 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2945141 Disease Relevance 2.24 Pain Relevance 0.82

To establish whether the attraction of neutrophils is correlated with the expression of chemokines, we next questioned whether SAH induced the expression of pulmonary macrophage inflammatory protein (MIP)-1?

Gene_expression (expression) of MIP in neutrophils associated with chemokine, inflammation and cva

7) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2945141 Disease Relevance 1.39 Pain Relevance 0.76

A single bi-functional monomer, N,O-bismethacryloyl ethanolamine (NOBE), was used in precipitation polymerization system to synthesize molecularly imprinted polymer (MIP) microspheres.

Gene_expression (synthesize) of MIP

8) Confidence 0.21 Published 2009 Journal Analyst Section Abstract Doc Link 19305921 Disease Relevance 0 Pain Relevance 0.23

At least six AQPs are expressed in the eye: AQP0 major intrinsic protein (MIP) in lens fiber; AQP1 in cornea endothelium, ciliary and lens epithelia, trabecular meshwork, and retinal photoreceptor cells; AQP3 in conjunctiva; AQP4 in ciliary epithelium and retinal Muller cells; AQP5 in corneal and lacrimal gland epithelia [18]; and AQP9 in retinal ganglion cells [19].

Gene_expression (expressed) of AQP0 major intrinsic protein in eye associated with ganglion cysts and disorders of the lacrimal system

9) Confidence 0.12 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.33 Pain Relevance 0.04

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