INT82887

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.40
Pain Relevance 4.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) aging (Ccl5) extracellular region (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
neuronal 1
plasma 1
neurons 1
peripheral nerves 1
Ccl5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 328 100.00 Very High Very High Very High
Inflammation 92 100.00 Very High Very High Very High
Sciatic nerve 45 98.72 Very High Very High Very High
Demyelination 142 98.52 Very High Very High Very High
Lasting pain 26 96.32 Very High Very High Very High
Pain 58 94.36 High High
hyperexcitability 15 94.00 High High
antagonist 64 91.68 High High
MU agonist 2 88.00 High High
Antinociceptive 3 87.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 87 100.00 Very High Very High Very High
Demyelinating Disease 149 98.52 Very High Very High Very High
Nervous System Injury 84 98.28 Very High Very High Very High
Pain 93 96.32 Very High Very High Very High
Immunization 2 87.80 High High
Disease 5 85.44 High High
Necrosis 4 82.28 Quite High
Cancer 4 81.92 Quite High
Rheumatoid Arthritis 39 75.00 Quite High
Experimental Autoimmune Neuritis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The plasma level of CCL5 was increased in MS patients before treatment and was also significantly decreased in the treatment of MS with MP and MTX.
Positive_regulation (increased) of CCL5 in plasma
1) Confidence 0.40 Published 2008 Journal Acta Neurol. Scand. Section Body Doc Link 18336625 Disease Relevance 0.08 Pain Relevance 0
RANTES message increased at day 13 and peaked at day 17 p.i.; however, unlike other chemokines, it showed a second peak of expression on day 24.
Positive_regulation (increased) of RANTES associated with chemokine
2) Confidence 0.34 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10408979 Disease Relevance 0.62 Pain Relevance 0.51
The chemokine SDF-1/CXCL12 and its receptor CXCR4 are constitutively expressed by peripheral nerves [3,27-29] and chemokines that activate CCR5 and CXCR3 receptors, such as RANTES and IP-10, are synthesized in association with neuroinflammatory responses [16,30].
Positive_regulation (activate) of RANTES in peripheral nerves associated with chemokine
3) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.38 Pain Relevance 0.58
Further analysis showed that pretreatment with neutralizing anti-TGF-beta1 blocked the ability of DAMGO to induce CCL5 or CXCR4.
Positive_regulation (induce) of CCL5
4) Confidence 0.25 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.87
Our findings in this sciatic nerve injury model differ from a report by Taskinen and Royotta [16] which demonstrated bilateral upregulation of non-neuronal RANTES for up to four weeks following sciatic nerve transection in the rat.
Positive_regulation (upregulation) of RANTES in neuronal associated with nervous system injury and sciatic nerve
5) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.65 Pain Relevance 0.92
Like CCR2, the CCR5 receptor function and its ligand, RANTES, were also strongly upregulated in DRG neurons in response to focal demyelination.
Positive_regulation (upregulated) of RANTES in neurons associated with demyelination
6) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.58 Pain Relevance 0.87
In the current study, we have detected activation responses mediated by TRPV1 and ROS that include increases in COX-2, RANTES and TNF?.
Positive_regulation (increases) of RANTES
7) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.36 Pain Relevance 0.60
The transient increase in the levels of IL-8 concurs with the results of recent experimental research showing a calcitonin gene-related peptide-induced activation of IL-8 gene expression, but not RANTES and MCP-1, via the transcriptional factor AP-2, which mediates transduction in response to cyclic adenosine monophosphate.
Positive_regulation (activation) of RANTES
8) Confidence 0.07 Published 2004 Journal Headache Section Body Doc Link 15546258 Disease Relevance 0 Pain Relevance 0
Stimulation of human clonal SW982 synoviocytes with resiniferatoxin, greatly increased immunocytochemical staining for the inflammatory enzyme COX-2 (Fig. 6A) and the chemokine RANTES (not shown) visualized at 24 h.
Positive_regulation (increased) of RANTES associated with chemokine and inflammation
9) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.15 Pain Relevance 0.24
Further, comparative analysis by semiquantitative RT-PCR analysis was performed for other CXC/CC chemokines (CXCL9, CXCL11, CCL3, CCL4, CCL5) and receptor (CCR5) which revealed their upregulation in the diseased state.
Positive_regulation (upregulation) of CCL5
10) Confidence 0.03 Published 2007 Journal Pancreatology Section Body Doc Link 17912012 Disease Relevance 0.06 Pain Relevance 0
In the LCP subgroup, serum IL-15, GM-CSF, and RANTES levels were reduced significantly, while serum IL-10 levels increased significantly only in the responder group after treatment.
Positive_regulation (increased) of RANTES
11) Confidence 0.01 Published 2001 Journal J Clin Apher Section Abstract Doc Link 11746532 Disease Relevance 0.52 Pain Relevance 0.32

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