INT82896

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.61
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
endometrium 2
apoptotic cells 1
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 138 97.92 Very High Very High Very High
lidocaine 1 85.52 High High
Dismenorea 4 66.44 Quite High
cytokine 9 54.04 Quite High
pain pelvic 6 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 128 100.00 Very High Very High Very High
Endometriosis 144 97.92 Very High Very High Very High
Hypoxia 3 89.20 High High
Death 24 85.60 High High
Dysmenorrhea 1 66.44 Quite High
Disease 15 47.92 Quite Low
Reprotox - General 1 6 22.80 Low Low
Cancer 3 10.72 Low Low
Reprotox - General 3 12 5.00 Very Low Very Low Very Low
Gynecological Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This marked increase was associated with a decrease in the intensity of the Bcl-2 immunostaining and an increase in the intensity of Bax and Bcl-x immunostaining.
Transcription (intensity) of Bax
1) Confidence 0.67 Published 1999 Journal Biol. Reprod. Section Abstract Doc Link 10411527 Disease Relevance 0.40 Pain Relevance 0.07
Curiously, we detected that both bax mRNA abundance and apoptotic cells were increased in early secretory phase in eutopic endometrium from women with endometriosis but not from normal women.
Transcription (abundance) of bax in apoptotic cells associated with endometriosis and apoptosis
2) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 1.39 Pain Relevance 0.22
Concomitantly to the absence of apoptosis in those endometria, the pro-apoptotic gene bax mRNA abundance was unchanged during the menstrual cycle, at difference at the increase exhibited in normal endometrium, suggesting that the reduction of bax expression may be a mechanism that could explain the decreased incidence of apoptosis in endometriosis.
Transcription (abundance) of bax in endometrium associated with endometriosis and apoptosis
3) Confidence 0.57 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 1.21 Pain Relevance 0.21
The abundance of bax mRNA increased at the end of the menstrual cycle in normal endometrium.
Transcription (abundance) of bax in endometrium
4) Confidence 0.51 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 0.98 Pain Relevance 0.21
Total RNA was extracted by northern blotting analysis and for Bcl-2, Bax and beta-actin RNA messenger detection, RT-PCR amplification was used.
Transcription (detection) of Bax associated with apoptosis
5) Confidence 0.47 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12653348 Disease Relevance 0.64 Pain Relevance 0.09

General Comments

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